Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Rebecca M. Sappington"'
Autor:
Da Ma, Wenyu Deng, Zain Khera, Thajunnisa A. Sajitha, Xinlei Wang, Gadi Wollstein, Joel S. Schuman, Sieun Lee, Haolun Shi, Myeong Jin Ju, Joanne Matsubara, Mirza Faisal Beg, Marinko Sarunic, Rebecca M. Sappington, Kevin C. Chan
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Excitotoxicity from the impairment of glutamate uptake constitutes an important mechanism in neurodegenerative diseases such as Alzheimer’s, multiple sclerosis, and Parkinson's disease. Within the eye, excitotoxicity is thought to play a c
Externí odkaz:
https://doaj.org/article/94d8962b31084b0ca53d23684c47756a
Autor:
Kevin C. Chan, Rebecca M. Sappington
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
Externí odkaz:
https://doaj.org/article/17bea75eb97f4c58a4d229006f6e4377
Publikováno v:
International Journal of Retina and Vitreous, Vol 8, Iss 1, Pp 1-8 (2022)
Abstract Background Methods of sclerotomy closure following a vitrectomy, including the use of sutures, have been associated with complications such as inflammation, foreign body sensation, and infection. Here, we test an innovative approach to scler
Externí odkaz:
https://doaj.org/article/d4eb1898d2314fd2b0f5b6431df70e9c
Autor:
Da Ma, Louis R. Pasquale, Michaël J. A. Girard, Christopher K. S. Leung, Yali Jia, Marinko V. Sarunic, Rebecca M. Sappington, Kevin C. Chan
Publikováno v:
Frontiers in Ophthalmology, Vol 2 (2023)
Artificial intelligence (AI) has been approved for biomedical research in diverse areas from bedside clinical studies to benchtop basic scientific research. For ophthalmic research, in particular glaucoma, AI applications are rapidly growing for pote
Externí odkaz:
https://doaj.org/article/d1df3a4b62d44d70a11f6f2797afe1ef
Autor:
Lauren K. Wareham, Franklin D. Echevarria, Jennifer L. Sousa, Danielle O. Konlian, Gabrielle Dallas, Cathryn R. Formichella, Priya Sankaran, Peter J. Goralski, Jenna R. Gustafson, Rebecca M. Sappington
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103141- (2021)
Summary: The interleukin-6 (IL-6) family of cytokines and its downstream effector, STAT3, are important mediators of neuronal health, repair, and disease throughout the CNS, including the visual system. Here, we elucidate a transcription-independent
Externí odkaz:
https://doaj.org/article/b63bd7395b34419184036396f2f520ab
Autor:
Lauren K. Wareham, Ana C. Dordea, Grigorij Schleifer, Vincent Yao, Annabelle Batten, Fei Fei, Joseph Mertz, Meredith Gregory-Ksander, Louis R. Pasquale, Emmanuel S. Buys, Rebecca M. Sappington
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 65-75 (2019)
The nitric oxide – guanylyl cyclase-1 – cyclic guanylate monophosphate (NO-GC-1–cGMP) pathway has emerged as a potential pathogenic mechanism for glaucoma, a common intraocular pressure (IOP)-related optic neuropathy characterized by the degene
Externí odkaz:
https://doaj.org/article/92a4bcd054ac4d3387fd86f1ecf77dac
Autor:
Rachel A. Fischer, Michael L. Risner, Abigail L. Roux, Lauren K. Wareham, Rebecca M. Sappington
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Glaucoma is a leading cause of blindness worldwide, resulting from degeneration of retinal ganglion cells (RGCs), which form the optic nerve. In glaucoma, axon transport deficits appear to precede structural degeneration of RGC axons. The period of t
Externí odkaz:
https://doaj.org/article/dad3d665b65840d8b8b77886824ede1f
Autor:
D’Anne S. Duncan, Rebecca L. Weiner, Carl Weitlauf, Michael L. Risner, Abigail L. Roux, Emily R. Sanford, Cathryn R. Formichella, Rebecca M. Sappington
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
The β-chemokine Ccl5 and its receptors are constitutively expressed in neurons of the murine inner retina. Here, we examined the functional and structural significance of this constitutive Ccl5 signaling on retinal development. We compared outcomes
Externí odkaz:
https://doaj.org/article/a1397087d9aa4a4a9073b02de6dbb374
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
The pleotropic cytokine interleukin-6 (IL-6) is implicated in retinal ganglion cell (RGC) survival and degeneration, including that associated with glaucoma. IL-6 protects RGCs from pressure-induced apoptosis in vitro. However, it is unknown how IL-6
Externí odkaz:
https://doaj.org/article/8429ffbdd5204f1696c0a3283d203570
Autor:
Sarfaraz Ahmad, Kendra N. Wright, Jessica L. VonCannon, Carlos M. Ferrario, Mohammad S. Ola, Mayur Choudhary, Goldis Malek, Jenna R. Gustafson, Rebecca M. Sappington
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 39:290-299