Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rebecca M. Ruddy"'
Autor:
Els Fieremans, Bradley J. MacIntosh, Jovanka Skocic, Freda D. Miller, Ramy Ayoub, Rebecca M. Ruddy, Daniel Derkach, Adeoye Oyefiade, Donald J. Mabbott, Elizabeth Cox, Cynthia B. de Medeiros, Suzanne Laughlin, Eric Bouffet, Cindi M. Morshead, Zahra Shirzadi, Benjamin Ades-Aron
Publikováno v:
Nat Med
We asked whether pharmacological stimulation of endogenous neural precursor cells (NPCs) may promote cognitive recovery and brain repair, focusing on the drug metformin, in parallel rodent and human studies of radiation injury. In the rodent cranial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11310f51f29fd96402971f493cc768d9
https://doi.org/10.1038/s41591-020-0985-2
https://doi.org/10.1038/s41591-020-0985-2
Publikováno v:
Science Advances
Metformin expands the neural precursor pool in adult females, but not males, and is correlated with cognitive recovery.
Resident neural stem and progenitor cells, collectively termed neural precursor cells (NPCs), reside in a well-defined neurog
Resident neural stem and progenitor cells, collectively termed neural precursor cells (NPCs), reside in a well-defined neurog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967f802dd288f74e85eb8c5e1b130dda
https://pubmed.ncbi.nlm.nih.gov/31535024
https://pubmed.ncbi.nlm.nih.gov/31535024
Publikováno v:
Brain Research. 1727:146548
Cranial irradiation is used in combination with other therapies as a treatment for brain tumours and is thought to contribute to long-term cognitive deficits. Several rodent models have demonstrated that these cognitive deficits may be correlated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03263ce938c884e20ed21e20a9ec6e9
https://doi.org/10.1016/j.brainres.2019.146548
https://doi.org/10.1016/j.brainres.2019.146548
Autor:
Cindi M. Morshead, Rebecca M. Ruddy
Publikováno v:
Cell and tissue research. 371(1)
Neural stem cells and their progeny reside in two distinct neurogenic niches within the mammalian brain: the subventricular zone and the dentate gyrus. The interplay between the neural stem cells and the niche in which they reside can have significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e9f6e2d2248f3546ec72d7a2428743
https://pubmed.ncbi.nlm.nih.gov/28776186
https://pubmed.ncbi.nlm.nih.gov/28776186
Publikováno v:
Synapse. 69:52-56
The authors demonstrate that different NMDAR antagonists (ketamine and MK-801) have varying effects on spine density depending on dose, drug regimen, and brain region. While acute ketamine treatment increases cortical spine density in mice, subchroni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c80e9b108342fc429baedf630fa26bb4
https://doi.org/10.1002/syn.21784
https://doi.org/10.1002/syn.21784