Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Rebecca M. Perrett"'
Autor:
Samantha M Mirczuk, Andrew J Lessey, Alice R Catterick, Rebecca M Perrett, Christopher J Scudder, Jordan E Read, Victoria J Lipscomb, Stijn J Niessen, Andrew J Childs, Craig A McArdle, Imelda M McGonnell, Robert C Fowkes
Publikováno v:
Cells, Vol 8, Iss 9, p 1086 (2019)
C-type natriuretic peptide (CNP) is the most conserved member of the mammalian natriuretic peptide family, and is implicated in the endocrine regulation of growth, metabolism and reproduction. CNP is expressed throughout the body, but is particularly
Externí odkaz:
https://doaj.org/article/f54fc781a0414f39b5e1f910f41b64d7
Autor:
Robert G. Nelson, Matthias Kretzler, Abigail C Lay, Viji Nair, Christopher R. Neal, Gavin I. Welsh, Jenny A Hurcombe, Marieangela C. Wilson, Raina D. Ramnath, Philip A. Lewis, A Fern Barrington, Kate J. Heesom, Wenjun Ju, Matthew J. Butler, Craig A. McArdle, Mark A. Graham, Denize Atan, Rebecca M. Perrett, Edward Mountjoy, Richard J M Coward, Simon C. Satchell, Eleanor Herbert
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Lay, A C, Barrington, A F, Hurcombe, J A, Ramnath, R D, Graham, M, Lewis, P A, Wilson, M C, Heesom, K J, Butler, M J, Perrett, R M, Neal, C R, Herbert, E, Mountjoy, E, Atan, D, Nair, V, Ju, W, Nelson, R G, Kretzler, M, Satchell, S C, McArdle, C A, Welsh, G I & Coward, R J M 2020, ' A role for NPY-NPY2R signaling in albuminuric kidney disease ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, 202004651, pp. 15862-15873 . https://doi.org/10.1073/pnas.2004651117
Lay, A C, Barrington, A F, Hurcombe, J A, Ramnath, R D, Graham, M, Lewis, P A, Wilson, M C, Heesom, K J, Butler, M J, Perrett, R M, Neal, C R, Herbert, E, Mountjoy, E, Atan, D, Nair, V, Ju, W, Nelson, R G, Kretzler, M, Satchell, S C, McArdle, C A, Welsh, G I & Coward, R J M 2020, ' A role for NPY-NPY2R signaling in albuminuric kidney disease ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, 202004651, pp. 15862-15873 . https://doi.org/10.1073/pnas.2004651117
Significance Neuropeptide Y (NPY) is implicated in many pathological conditions including obesity, diabetes, and insulin resistance. However, a pathogenic role of NPY in kidney disease has not been described. We found that NPY is produced by the podo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cd8936d1a4b3df29684254bf4466ee
http://europepmc.org/articles/PMC7355002
http://europepmc.org/articles/PMC7355002
Autor:
Hussah Alobaid, Thanh Pham, Krasimira Tsaneva-Atanasova, Kathryn Garner, Craig A. McArdle, Rebecca M. Perrett, Margaritis Voliotis
Publikováno v:
Garner, K, Voliotis, M, Alobaid, H M S, Perrett, R M, Pham, T, Tsaneva-Atanasova, K & McArdle, C 2017, ' Information Transfer via Gonadotropin-Releasing Hormone Receptors to ERK and NFAT : Sensing GnRH and Sensing Dynamics ', Journal of the Endocrine Society, vol. 1, no. 4, pp. 260-277 . https://doi.org/10.1210/js.2016-1096
Journal of the Endocrine Society
Journal of the Endocrine Society
Information theoretic approaches can be used to quantify information transfer via cell signaling networks. In this study, we do so for gonadotropin-releasing hormone (GnRH) activation of extracellular signal-regulated kinase (ERK) and nuclear factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42e25f4e4af964fbb75803f28588067
https://doi.org/10.1210/js.2016-1096
https://doi.org/10.1210/js.2016-1096
Autor:
Clive G. Bowsher, Craig A. McArdle, Thanh Pham, Kathryn Garner, George R. Pope, Christopher J. Caunt, Rebecca M. Perrett, Margaritis Voliotis, Krasimira Tsaneva-Atanasova
Publikováno v:
Journal of Biological Chemistry. 291:2246-2259
Cell signaling pathways are noisy communication channels, and statistical measures derived from information theory can be used to quantify the information they transfer. Here we use single cell signaling measures to calculate mutual information as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2441e0a34fad547ae2b641a91bd5f317
https://doi.org/10.1074/jbc.m115.686964
https://doi.org/10.1074/jbc.m115.686964
Autor:
Rebecca M. Perrett
Publikováno v:
Clinical Reproductive Science
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23e0373c6809dfdac4c0fa693f1498ed
https://doi.org/10.1002/9781118977231.ch1
https://doi.org/10.1002/9781118977231.ch1
Publikováno v:
Molecular and Cellular Neuroscience. 66:21-28
Parkinson's disease is primarily a movement disorder with predilection for the nigral dopaminergic neurons and is often associated with widespread neurodegeneration and diffuse Lewy body deposition. Recent advances in molecular genetics and studies i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3dfbb405b5a73a5b9433551be3208c
https://doi.org/10.1016/j.mcn.2015.02.009
https://doi.org/10.1016/j.mcn.2015.02.009
Autor:
Craig A. McArdle, Robert C. Fowkes, Christopher J. Caunt, Rebecca M. Perrett, Clive G. Bowsher, Krasimira Tsaneva-Atanasova
Publikováno v:
Journal of Biological Chemistry. 288:21001-21014
Many extracellular signals act via the Raf/MEK/ERK cascade in which kinetics, cell-cell variability, and sensitivity of the ERK response can all influence cell fate. Here we used automated microscopy to explore the effects of ERK-mediated negative fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6446a29fd2593f7fda640e5206c05a88
https://doi.org/10.1074/jbc.m113.455345
https://doi.org/10.1074/jbc.m113.455345
Autor:
Alfred L. Goldberg, M Elschami, Olaf Ansorge, D Mazaraki, George K. Tofaris, Rebecca M. Perrett, Zoi Alexopoulou, Áron Szabó, Benedikt M. Kessler, J Lang, Hye-Yeong Kim, Hurry, Tudor A. Fulga
Publikováno v:
Proceedings of the National Academy of Sciences. 113
In Parkinson’s disease, misfolded α-synuclein accumulates, often in a ubiquitinated form, in neuronal inclusions termed Lewy bodies. An important outstanding question is whether ubiquitination in Lewy bodies is directly relevant to α-synuclein tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075f4eff1b72d292837dfa4ea54eae6d
https://doi.org/10.1073/pnas.1523597113
https://doi.org/10.1073/pnas.1523597113
Autor:
Aurélia E. Lewis, Linda Aumo, Rebecca M. Perrett, Nancy R. Stallings, Erling A. Hoivik, Marit Bakke, Neil A. Hanley, Haldis Lillefosse, Reidun Aesoy
Publikováno v:
Endocrinology. 149:5599-5609
Steroidogenic factor 1 (SF1) is expressed in a time- and cell-specific manner in the endocrine system. In this study we present evidence to support that methylation of CpG sites located in the proximal promoter of the gene encoding SF1 contributes to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8de90bde250b702e1fd1d17f167a7de
https://doi.org/10.1210/en.2008-0104
https://doi.org/10.1210/en.2008-0104
Autor:
Judith J. Eckert, Lee Turnpenny, Ewa Rajpert-De Meyts, Marie O'shea, Iain T. Cameron, Si Brask Sonne, Neil A. Hanley, Rebecca M. Perrett, David I. Wilson
Publikováno v:
Biology of Reproduction. 78:852-858
NANOG, POU5F1, and SOX2 are required by the inner cell mass of the blastocyst and act cooperatively to maintain pluripotency in both mouse and human embryonic stem cells. Inadequacy of any one of them causes loss of the undifferentiated state. Mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4622c5bf5ced068812489751442ff88e
https://doi.org/10.1095/biolreprod.107.066175
https://doi.org/10.1095/biolreprod.107.066175