Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Rebecca M. Lennen"'
Autor:
Elsayed T. Mohamed, Shizeng Wang, Rebecca M. Lennen, Markus J. Herrgård, Blake A. Simmons, Steven W. Singer, Adam M. Feist
Publikováno v:
Microbial Cell Factories, Vol 16, Iss 1, Pp 1-15 (2017)
Abstract Background There is a need to replace petroleum-derived with sustainable feedstocks for chemical production. Certain biomass feedstocks can meet this need as abundant, diverse, and renewable resources. Specific ionic liquids (ILs) can play a
Externí odkaz:
https://doaj.org/article/401b88f09725456181c7640814f9f512
Autor:
Rebecca M. Lennen, Hyun Gyu Lim, Kristian Jensen, Elsayed T. Mohammed, Patrick V. Phaneuf, Myung Hyun Noh, Sailesh Malla, Rosa A. Börner, Ksenia Chekina, Emre Özdemir, Ida Bonde, Anna Koza, Jérôme Maury, Lasse E. Pedersen, Lars Y. Schöning, Nikolaus Sonnenschein, Bernhard O. Palsson, Alex T. Nielsen, Morten O.A. Sommer, Markus J. Herrgård, Adam M. Feist
Publikováno v:
Lennen, R M, Lim, H G, Jensen, K, Mohammed, E T, Phaneuf, P V, Noh, M H, Malla, S, Börner, R A, Chekina, K, Özdemir, E, Bonde, I, Koza, A, Maury, J, Pedersen, L E, Schöning, L Y, Sonnenschein, N, Palsson, B O, Nielsen, A T, Sommer, M O A, Herrgård, M J & Feist, A M 2023, ' Laboratory evolution reveals general and specific tolerance mechanisms for commodity chemicals ', Metabolic Engineering, vol. 76, pp. 179-192 . https://doi.org/10.1016/j.ymben.2023.01.012
Although strain tolerance to high product concentrations is a barrier to the economically viable biomanufacturing of industrial chemicals, chemical tolerance mechanisms are often unknown. To reveal tolerance mechanisms, an automated platform was util
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eef3b3ec046b6eb72590ff507703662
https://orbit.dtu.dk/en/publications/17e1f922-158c-4009-be96-42432c05ae98
https://orbit.dtu.dk/en/publications/17e1f922-158c-4009-be96-42432c05ae98
Autor:
Muyao Wu, Josefin Johnsen, Daniel C. Zielinski, Patrick V. Phaneuf, Sebastian Schulz, Rebecca M. Lennen, Adam M. Feist, Richard Szubin, Bernhard O. Palsson, James T. Yurkovich, Se Hyeuk Kim, Christopher Dalldorf, Emre Özdemir, Lei Yang
Publikováno v:
Phaneuf, P V, Zielinski, D C, Yurkovich, J T, Johnsen, J, Szubin, R, Yang, L, Kim, S H, Schulz, S, Wu, M, Dalldorf, C, Ozdemir, E, Lennen, R M, Palsson, B O & Feist, A M 2021, ' Escherichia coli Data-Driven Strain Design Using Aggregated Adaptive Laboratory Evolution Mutational Data ', ACS Synthetic Biology, vol. 10, no. 12, pp. 3379–3395 . https://doi.org/10.1021/acssynbio.1c00337
Microbes are being engineered for an increasingly large and diverse set of applications. However, the designing of microbial genomes remains challenging due to the general complexity of biological systems. Adaptive Laboratory Evolution (ALE) leverage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb459cb43c19d50489f8275b673ac489
https://orbit.dtu.dk/en/publications/04ef970a-201f-4d43-a05c-70b9bae58c52
https://orbit.dtu.dk/en/publications/04ef970a-201f-4d43-a05c-70b9bae58c52
Autor:
Rebecca M Lennen, Brian F Pfleger
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54031 (2013)
Microbial synthesis of free fatty acids (FFA) is a promising strategy for converting renewable sugars to advanced biofuels and oleochemicals. Unfortunately, FFA production negatively impacts membrane integrity and cell viability in Escherichia coli,
Externí odkaz:
https://doaj.org/article/65bbd79267f2431fb6c5b6e0ed2334e2
Autor:
Ida Bonde, Rosa Aragão Börner, Kristian Ejlebjerg Jensen, Lars Y. Schöning, Emre Özdemir, Nikolaus Sonnenschein, Bernhard O. Palsson, Lasse Ebdrup Pedersen, Adam M. Feist, Anna Koza, Ksenia Chekina, Morten Otto Alexander Sommer, Sailesh Malla, Jerome Maury, Alex Toftgaard Nielsen, Rebecca M. Lennen, Markus J. Herrgård, Elsayed T. Mohammed
Tolerance to high product concentrations is a major barrier to achieving economically viable processes for bio-based chemical production. Chemical tolerance mechanisms are often unknown, thus their rational design is not achievable. To reveal unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e18dd9413d83240b82db0e4b619b4a
https://doi.org/10.1101/634105
https://doi.org/10.1101/634105
Autor:
Spencer W, Hoover, J Tyler, Youngquist, Phil A, Angart, Sydnor T, Withers, Rebecca M, Lennen, Brian F, Pfleger
Publikováno v:
Environmental progresssustainable energy. 31(1)
Biological production of hydrocarbons is an attractive strategy to produce drop-in replacement transportation fuels. Several methods for converting microbially-produced fatty acids into reduced compounds compatible with petrodiesel have been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0259a8e2719f78a9ab5337d44a22e469
https://pubmed.ncbi.nlm.nih.gov/30034576
https://pubmed.ncbi.nlm.nih.gov/30034576
Autor:
Anna Koza, Alex Toftgaard Nielsen, Rebecca M. Lennen, Klara Bojanovic, Sheila Ingemann Jensen, Patricia Calero
Publikováno v:
Calero, P, Jensen, S I, Bojanovič, K, Lennen, R, Koza, A & Nielsen, A T 2018, ' Genome-wide identification of tolerance mechanisms toward p-coumaric acid in Pseudomonas putida ', Biotechnology and Bioengineering, vol. 115, no. 3, pp. 762-774 . https://doi.org/10.1002/bit.26495
Biotechnology and Bioengineering
Biotechnology and Bioengineering
The soil bacterium Pseudomonas putida KT2440 has gained increasing biotechnological interest due to its ability to tolerate different types of stress. Here, the tolerance of P. putida KT2440 towards eleven toxic chemical compounds was investigated. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba93440c47e58202d2337989fff5498
https://orbit.dtu.dk/en/publications/de7a0e08-58a2-4bde-a5ed-18d026055c7e
https://orbit.dtu.dk/en/publications/de7a0e08-58a2-4bde-a5ed-18d026055c7e
Publikováno v:
Genes
Shepelin, D, Hansen, A S L, Lennen, R, Luo, H & Herrgård, M J 2018, ' Selecting the Best: Evolutionary Engineering of Chemical Production in Microbes ', Genes, vol. 9, no. 5, 249 . https://doi.org/10.3390/genes9050249
Shepelin, D, Hansen, A S L, Lennen, R, Luo, H & Herrgård, M J 2018, ' Selecting the Best: Evolutionary Engineering of Chemical Production in Microbes ', Genes, vol. 9, no. 5, 249 . https://doi.org/10.3390/genes9050249
Microbial cell factories have proven to be an economical means of production for many bulk, specialty, and fine chemical products. However, we still lack both a holistic understanding of organism physiology and the ability to predictively tune enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b5e62d14a3c459565b8e5d1f3dd8f5
Autor:
Elsayed Tharwat Tolba Mohamed, Blake A. Simmons, Markus J. Herrgård, Adam M. Feist, Steven W. Singer, Rebecca M. Lennen, Shizeng Wang
Publikováno v:
Microbial cell factories, vol 16, iss 1
Mohamed, E T, Wang, S, Lennen, R M, Herrgård, M J, Simmons, B A, Singer, S W & Feist, A M 2017, ' Generation of a platform strain for ionic liquid tolerance using adaptive laboratory evolution ', Microbial Cell Factories, vol. 16, no. 1, 204 . https://doi.org/10.1186/s12934-017-0819-1
Microbial Cell Factories, Vol 16, Iss 1, Pp 1-15 (2017)
Mohamed, ET; Wang, S; Lennen, RM; Herrgård, MJ; Simmons, BA; Singer, SW; et al.(2017). Generation of a platform strain for ionic liquid tolerance using adaptive laboratory evolution. Microbial Cell Factories, 16(1). doi: 10.1186/s12934-017-0819-1. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/4473v9vd
Microbial Cell Factories
Mohamed, E T, Wang, S, Lennen, R M, Herrgård, M J, Simmons, B A, Singer, S W & Feist, A M 2017, ' Generation of a platform strain for ionic liquid tolerance using adaptive laboratory evolution ', Microbial Cell Factories, vol. 16, no. 1, 204 . https://doi.org/10.1186/s12934-017-0819-1
Microbial Cell Factories, Vol 16, Iss 1, Pp 1-15 (2017)
Mohamed, ET; Wang, S; Lennen, RM; Herrgård, MJ; Simmons, BA; Singer, SW; et al.(2017). Generation of a platform strain for ionic liquid tolerance using adaptive laboratory evolution. Microbial Cell Factories, 16(1). doi: 10.1186/s12934-017-0819-1. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/4473v9vd
Microbial Cell Factories
Background There is a need to replace petroleum-derived with sustainable feedstocks for chemical production. Certain biomass feedstocks can meet this need as abundant, diverse, and renewable resources. Specific ionic liquids (ILs) can play a role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65437be3ca74cb60160859e8d4945ea5
https://escholarship.org/uc/item/4473v9vd
https://escholarship.org/uc/item/4473v9vd
Publikováno v:
Hansen, A S L, Lennen, R M, Sonnenschein, N & Herrgard, M 2017, ' Systems biology solutions for biochemical production challenges ', Current Opinion in Biotechnology, vol. 45, pp. 85-91 . https://doi.org/10.1016/j.copbio.2016.11.018
Current Opinion in Biotechnology
Current Opinion in Biotechnology
There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the fie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ca0ea60218d70f5cfcf933e3c1bede
https://orbit.dtu.dk/en/publications/82d70d8f-916a-4617-916e-00b48a0029a9
https://orbit.dtu.dk/en/publications/82d70d8f-916a-4617-916e-00b48a0029a9