Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Rebecca M. Hill"'
Autor:
Oliver J. Mainwaring, Holger Weishaupt, Miao Zhao, Gabriela Rosén, Anna Borgenvik, Laura Breinschmid, Annemieke D. Verbaan, Stacey Richardson, Dean Thompson, Steven C. Clifford, Rebecca M. Hill, Karl Annusver, Anders Sundström, Karl O. Holmberg, Maria Kasper, Sonja Hutter, Fredrik J. Swartling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
CDKN2A loss and p53 mutations are rare in MYC-driven Group 3 medulloblastomas (MBs). Here the authors generated a transgenic mouse model of Group 3 MB by MYC overexpression and show that MYC suppresses ARF to drive tumorigenesis.
Externí odkaz:
https://doaj.org/article/15ce094130ad4d1185c37a3fd0a60446
Publikováno v:
Children, Vol 9, Iss 7, p 1058 (2022)
Background: The deleterious impact upon the cognitive development of survivors of pediatric brain tumors (PBT) is well documented. Impairment in cognitive function is associated with reduced health-related quality of life (HRQoL), such that survivors
Externí odkaz:
https://doaj.org/article/d3a7e862b18849b3b6500a98ace58046
Autor:
Jack Goddard, Jemma Castle, Emily Southworth, Anya Fletcher, Stephen Crosier, Idoia Martin-Guerrero, Miguel García-Ariza, Aurora Navajas, Julien Masliah-Planchon, Franck Bourdeaut, Christelle Dufour, Olivier Ayrault, Tobias Goschzik, Torsten Pietsch, Martin Sill, Stefan M. Pfister, Stefan Rutkowski, Stacey Richardson, Rebecca M. Hill, Daniel Williamson, Simon Bailey, Edward C. Schwalbe, Steven C. Clifford, Debbie Hicks
Publikováno v:
Acta Neuropathologica. 145:651-666
Group 4 tumours (MBGrp4) represent the majority of non-WNT/non-SHH medulloblastomas. Their clinical course is poorly predicted by current risk-factors. MBGrp4 molecular substructures have been identified (e.g. subgroups/cytogenetics/mutations), howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31310920651d70af98043527424bb4d7
https://doi.org/10.1007/s00401-023-02566-0
https://doi.org/10.1007/s00401-023-02566-0
Publikováno v:
Neuropsychological Rehabilitation. :1-21
The growing population of survivors of childhood brain tumors present the challenge of long-term quality of survival. The domains most affected by tumor and treatment are those implicated in development of typical intellectual functions: attention, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e8f2692a6a266020ef4c0dc992af21
https://doi.org/10.1080/09602011.2022.2157446
https://doi.org/10.1080/09602011.2022.2157446
Autor:
Fredrik J. Swartling, Holger Weishaupt, Robert J. Wechsler-Reya, Ulrich Schüller, Steven C. Clifford, Olle Sangfelt, Michael D. Taylor, Xingqi Chen, Géraldine Giraud, Helena Jernberg-Wiklund, Matko Čančer, Marc Remke, Antonia Kalushkova, Adrian M. Dubuc, Rebecca M. Hill, Grammatiki Fotaki, Stacey Richardson, Amelie S. Wenz, Yonglong Dang, Mar Ballester Bravo, Anders Sundström, Jessica M. Rusert, Annemieke D. Verbaan, Damiana Sattanino, Oliver J. Mainwaring, Thale Kristin Olsen, Tobias Bergström, Aldwin Suryo Rahmanto, Alexandra Garancher, Sonja Hutter, Gabriela Rosén, Vasil Savov, Miao Zhao, Sara Bolin, Karl O. Holmberg, Anna Borgenvik
Resource Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f9e62c1e38cb49885bbd558c5c889e
https://doi.org/10.1158/0008-5472.22433306
https://doi.org/10.1158/0008-5472.22433306
Autor:
Fredrik J. Swartling, Holger Weishaupt, Robert J. Wechsler-Reya, Ulrich Schüller, Steven C. Clifford, Olle Sangfelt, Michael D. Taylor, Xingqi Chen, Géraldine Giraud, Helena Jernberg-Wiklund, Matko Čančer, Marc Remke, Antonia Kalushkova, Adrian M. Dubuc, Rebecca M. Hill, Grammatiki Fotaki, Stacey Richardson, Amelie S. Wenz, Yonglong Dang, Mar Ballester Bravo, Anders Sundström, Jessica M. Rusert, Annemieke D. Verbaan, Damiana Sattanino, Oliver J. Mainwaring, Thale Kristin Olsen, Tobias Bergström, Aldwin Suryo Rahmanto, Alexandra Garancher, Sonja Hutter, Gabriela Rosén, Vasil Savov, Miao Zhao, Sara Bolin, Karl O. Holmberg, Anna Borgenvik
Supplementary figure 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1912492597cfade9206b22e304f40fbd
https://doi.org/10.1158/0008-5472.22433336
https://doi.org/10.1158/0008-5472.22433336
Autor:
Fredrik J. Swartling, Holger Weishaupt, Robert J. Wechsler-Reya, Ulrich Schüller, Steven C. Clifford, Olle Sangfelt, Michael D. Taylor, Xingqi Chen, Géraldine Giraud, Helena Jernberg-Wiklund, Matko Čančer, Marc Remke, Antonia Kalushkova, Adrian M. Dubuc, Rebecca M. Hill, Grammatiki Fotaki, Stacey Richardson, Amelie S. Wenz, Yonglong Dang, Mar Ballester Bravo, Anders Sundström, Jessica M. Rusert, Annemieke D. Verbaan, Damiana Sattanino, Oliver J. Mainwaring, Thale Kristin Olsen, Tobias Bergström, Aldwin Suryo Rahmanto, Alexandra Garancher, Sonja Hutter, Gabriela Rosén, Vasil Savov, Miao Zhao, Sara Bolin, Karl O. Holmberg, Anna Borgenvik
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22efa60c78744a2d1ee1b74fa2e6c10b
https://doi.org/10.1158/0008-5472.22433321.v1
https://doi.org/10.1158/0008-5472.22433321.v1
Autor:
Fredrik J. Swartling, Holger Weishaupt, Robert J. Wechsler-Reya, Ulrich Schüller, Steven C. Clifford, Olle Sangfelt, Michael D. Taylor, Xingqi Chen, Géraldine Giraud, Helena Jernberg-Wiklund, Matko Čančer, Marc Remke, Antonia Kalushkova, Adrian M. Dubuc, Rebecca M. Hill, Grammatiki Fotaki, Stacey Richardson, Amelie S. Wenz, Yonglong Dang, Mar Ballester Bravo, Anders Sundström, Jessica M. Rusert, Annemieke D. Verbaan, Damiana Sattanino, Oliver J. Mainwaring, Thale Kristin Olsen, Tobias Bergström, Aldwin Suryo Rahmanto, Alexandra Garancher, Sonja Hutter, Gabriela Rosén, Vasil Savov, Miao Zhao, Sara Bolin, Karl O. Holmberg, Anna Borgenvik
Relapse is the leading cause of death in patients with medulloblastoma, the most common malignant pediatric brain tumor. A better understanding of the mechanisms underlying recurrence could lead to more effective therapies for targeting tumor relapse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b77886ca8f27c3b99dc19b07dfadb1
https://doi.org/10.1158/0008-5472.c.6514337.v1
https://doi.org/10.1158/0008-5472.c.6514337.v1
Autor:
Marina Danilenko, Masood Zaka, Claire Keeling, Stephen Crosier, Stephanie Lyman, Martina Finetti, Daniel Williamson, Rafiqul Hussain, Jonathan Coxhead, Peixun Zhou, Rebecca M. Hill, Debbie Hicks, Vikki Rand, Abhijit Joshi, Edward C. Schwalbe, Simon Bailey, Steven C. Clifford
We reconstructed the natural history and temporal evolution of the most common childhood brain malignancy, medulloblastoma, by single-cell whole-genome sequencing (sc-WGS) of tumours representing its major molecular sub-classes and clinical risk grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6652e5b40f6a83ad786dfd700d3915c7
https://nrl.northumbria.ac.uk/id/eprint/49790/8/s00401-022-02464-x.pdf
https://nrl.northumbria.ac.uk/id/eprint/49790/8/s00401-022-02464-x.pdf
Autor:
Daniel Williamson, Edward C Schwalbe, Debbie Hicks, Kimberly A Aldinger, Janet C Lindsey, Stephen Crosier, Stacey Richardson, Jack Goddard, Rebecca M Hill, Jemma Castle, Yura Grabovska, James Hacking, Barry Pizer, Stephen B Wharton, Thomas S Jacques, Abhijit Joshi, Simon Bailey, Steven C Clifford
SummaryMedulloblastoma is currently sub-classified into distinct DNA methylation subgroups/subtypes with particular clinico-molecular features. Using RNA-seq in large well annotated cohorts of medulloblastoma we show that transcriptionally Group3 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a23c77ecac48c103e0e60126a975bf
https://doi.org/10.1101/2022.06.09.495353
https://doi.org/10.1101/2022.06.09.495353