Výsledky vyhledávání - "Rebecca M. Heidker"

Akademický článek

Metabolic pathways as possible therapeutic targets for progressive multiple sclerosis

Autor: Rebecca M Heidker, Mitchell R Emerson, Steven M LeVine

Publikováno v: Neural Regeneration Research, Vol 12, Iss 8, Pp 1262-1267 (2017)

Unlike relapsing remitting multiple sclerosis, there are very few therapeutic options for patients with progressive forms of multiple sclerosis. While immune mechanisms are key participants in the pathogenesis of relapsing remitting multiple sclerosi

Externí odkaz: https://doaj.org/article/c79cba892a714d7eb2d46c540cde3ca6

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Akademický článek

Grape Seed Procyanidins and Cholestyramine Differentially Alter Bile Acid and Cholesterol Homeostatic Gene Expression in Mouse Intestine and Liver.

Autor: Rebecca M Heidker, Gianella C Caiozzi, Marie-Louise Ricketts

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0154305 (2016)

Bile acid (BA) sequestrants, lipid-lowering agents, may be prescribed as a monotherapy or combination therapy to reduce the risk of coronary artery disease. Over 33% of adults in the United States use complementary and alternative medicine strategies

Externí odkaz: https://doaj.org/article/01f0b4e75172440aa32ec51132027c45

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Akademický článek

A Grape Seed Procyanidin Extract Ameliorates Fructose-Induced Hypertriglyceridemia in Rats via Enhanced Fecal Bile Acid and Cholesterol Excretion and Inhibition of Hepatic Lipogenesis.

Autor: Laura E Downing, Rebecca M Heidker, Gianella C Caiozzi, Brian S Wong, Kelvin Rodriguez, Fernando Del Rey, Marie-Louise Ricketts

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0140267 (2015)

The objective of this study was to determine whether a grape seed procyanidin extract (GSPE) exerts a triglyceride-lowering effect in a hyperlipidemic state using the fructose-fed rat model and to elucidate the underlying molecular mechanisms. Rats w

Externí odkaz: https://doaj.org/article/e2abc7c6cc8641229e2e9aff047674b2

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translin Is Required for Metabolic Regulation of Sleep

Autor: Justin R. DiAngelo, Wesley L. Bollinger, Beat Suter, Kazuma Murakami, Young-Joon Kim, Bethany A. Stahl, Robert M. Gingras, Maria E. Yurgel, Aradhana Mehta, Pavel Masek, Rebecca M. Heidker, William W. Ja, Alex C. Keene

Publikováno v: Current Biology. 26:972-980

Dysregulation of sleep or feeding has enormous health consequences. In humans, acute sleep loss is associated with increased appetite and insulin insensitivity, while chronically sleep-deprived individuals are more likely to develop obesity, metaboli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048ed2d047ff8525658856e98166b6ad
https://doi.org/10.1016/j.cub.2016.02.013

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Dietary procyanidins selectively modulate intestinal farnesoid X receptor-regulated gene expression to alter enterohepatic bile acid recirculation: elucidation of a novel mechanism to reduce triglyceridemia

Autor: Marie-Louise Ricketts, Gianella C. Caiozzi, Rebecca M. Heidker

Publikováno v: Molecular Nutrition & Food Research. 60:727-736

Scope Understanding the molecular basis by which dietary procyanidins modulate triglyceride and cholesterol homeostasis has important implications for the use of natural products in the treatment and prevention of cardiovascular disease. Methods To d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f419894aaf4bb35c36ef287260edbf
https://doi.org/10.1002/mnfr.201500795

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Metabolic pathways as possible therapeutic targets for progressive multiple sclerosis

Autor: Mitchell R. Emerson, Steven M. LeVine, Rebecca M. Heidker

Publikováno v: Neural Regeneration Research
Neural Regeneration Research, Vol 12, Iss 8, Pp 1262-1267 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce16fc9cb266d7e088b89dbbcaf17a3
https://pubmed.ncbi.nlm.nih.gov/28966637

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Intersections of pathways involving biotin and iron relative to therapeutic mechanisms for progressive multiple sclerosis

Autor: Rebecca M, Heidker, Mitchell R, Emerson, Steven M, LeVine

Publikováno v: Discovery medicine. 22(123)

While there are a variety of therapies for relapsing remitting multiple sclerosis (MS), there is a lack of treatments for progressive MS. An early study indicated that high dose biotin therapy has beneficial effects in approximately 12-15% of patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6fbe05282e13589c9f54278cab253b11
https://pubmed.ncbi.nlm.nih.gov/28147220

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