Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Rebecca M Sebastian"'
Autor:
Jimin Yoon, Emmanuel E Nekongo, Jessica E Patrick, Tiffani Hui, Angela M Phillips, Anna I Ponomarenko, Samuel J Hendel, Rebecca M Sebastian, Yu Meng Zhang, Vincent L Butty, C Brandon Ogbunugafor, Yu-Shan Lin, Matthew D Shoulders
Publikováno v:
PLoS Biology, Vol 20, Iss 2, p e3001569 (2022)
The sequence space accessible to evolving proteins can be enhanced by cellular chaperones that assist biophysically defective clients in navigating complex folding landscapes. It is also possible, at least in theory, for proteostasis mechanisms that
Externí odkaz:
https://doaj.org/article/84a99207a4a64c3fae29a7c8fe2ebd4a
Autor:
Asmita Choudhury, Anuradha Ratna, Arlene Lim, Rebecca M. Sebastian, Christopher L. Moore, Aveline A. Filliol, Jacob Bledsoe, Chengkai Dai, Robert F. Schwabe, Matthew D. Shoulders, Pranoti Mandrekar
Publikováno v:
Hepatology Communications, Vol 6, Iss 10, Pp 2781-2797 (2022)
Abstract Liver fibrosis is an aberrant wound healing response that results from chronic injury and is mediated by hepatocellular death and activation of hepatic stellate cells (HSCs). While induction of oxidative stress is well established in fibroti
Externí odkaz:
https://doaj.org/article/e0da366ac2af47d0911440f53019b5d4
Publikováno v:
Annu Rev Biochem
PMC
PMC
© 2020 Annual Reviews Inc.. All rights reserved. Protein folding in the cell is mediated by an extensive network of >1,000 chaperones, quality control factors, and trafficking mechanisms collectively termed the proteostasis network. While the compon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9dbc0dbf6ea934e5eeafed450baebce
https://doi.org/10.1146/annurev-biochem-013118-111552
https://doi.org/10.1146/annurev-biochem-013118-111552
Autor:
Viet Q. Chau, Yusuf Talha Tamer, Hui Peng, Erdal Toprak, Mark A. T. Blaskovich, Rebecca M. Sebastian, M. Rhia L. Stone, Marian Renwick, John D. Hulleman, Andrew Y. Koh, Wanida Phetsang, Shyamtanu Datta
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss, Pp 27-39 (2019)
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss, Pp 27-39 (2019)
The E. coli dihydrofolate reductase (DHFR) destabilizing domain (DD), which shows promise as a biologic tool and potential gene therapy approach, can be utilized to achieve spatial and temporal control of protein abundance in vivo simply by administr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2497b537716d9187d3738c9f62fb2c1
http://europepmc.org/articles/PMC6804886
http://europepmc.org/articles/PMC6804886
Autor:
Christopher L. Moore, Frauke Liebelt, Huib Ovaa, Monique P. C. Mulder, Matthew D. Shoulders, Alfred C.O. Vertegaal, Rebecca M. Sebastian
Publikováno v:
Cell Reports
Cell Reports, 26(1), 236
Elsevier
Cell Reports, 26(1), 236
Elsevier
Summary The role of stress-induced increases in SUMO2/3 conjugation during the heat shock response (HSR) has remained enigmatic. We investigated SUMO signal transduction at the proteomic and functional level during the HSR in cells depleted of proteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d9621d7986a01e336504e0176c0992
https://pubmed.ncbi.nlm.nih.gov/30605679
https://pubmed.ncbi.nlm.nih.gov/30605679
Autor:
Hui Peng, Viet Q. Chau, Wanida Phetsang, Rebecca M. Sebastian, M. Rhia L. Stone, Shyamtanu Datta, Marian Renwick, Yusuf T. Tamer, Erdal Toprak, Andrew Y. Koh, Mark A.T. Blaskovich, John D. Hulleman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 27-39 (2019)
The E. coli dihydrofolate reductase (DHFR) destabilizing domain (DD), which shows promise as a biologic tool and potential gene therapy approach, can be utilized to achieve spatial and temporal control of protein abundance in vivo simply by administr
Externí odkaz:
https://doaj.org/article/55bb1e55faf248afbdc0ebf40ebb3cfc