Bilateral remote ischemic conditioning in children: A two-center, double-blind, randomized controlled trial in young children undergoing cardiac surgeryCentral MessagePerspective

Autor: Nigel E. Drury, PhD, FRCS(CTh), Carin van Doorn, MD, FRCS(CTh), Rebecca L. Woolley, MSc, Rebecca J. Amos-Hirst, MSc, Rehana Bi, BSc(Hons), Collette M. Spencer, BSc(Hons), Kevin P. Morris, MD, FRCPCH, James Montgomerie, MD, FRCA, John Stickley, BSc, Adrian Crucean, MD, Alicia Gill, MSc, Matt Hill, MSc, Ralf J.M. Weber, PhD, Lukas Najdekr, PhD, Andris Jankevics, PhD, Andrew D. Southam, PhD, Gavin R. Lloyd, PhD, Osama Jaber, MD, Imre Kassai, PhD, Giuseppe Pelella, MD, Natasha E. Khan, MD, FRCS(CTh), Phil Botha, PhD, FRCS(CTh), David J. Barron, MD, FRCS(CTh), Melanie Madhani, PhD, Warwick B. Dunn, PhD, Natalie J. Ives, MSc, Paulus Kirchhof, MD, Timothy J. Jones, MD, FRCS(CTh), Edmund D. Carver, Alistair J. Cranston, Fraser Harban, Vasco Laginha Rolo, Ritchie Marcus, Anthony Moriarty, Raju Reddy, Susanna N. Ritchie-McLean, Monica A. Stokes, Ayngara Thillaivasan, Nandlal Bhatia, Carol Bodlani, Wendy Lim, Joe Mellor, Jutta Scheffczik

Publikováno v: JTCVS Open, Vol 18, Iss , Pp 193-208 (2024)

Objective: The study objective was to determine whether adequately delivered bilateral remote ischemic preconditioning is cardioprotective in young children undergoing surgery for 2 common congenital heart defects with or without cyanosis. Methods: W

Externí odkaz: https://doaj.org/article/dff6356b9ff249ccb9d12ee4838ec4a3

Bilateral Remote Ischaemic Conditioning in Children (BRICC) trial: protocol for a two-centre, double-blind, randomised controlled trial in young children undergoing cardiac surgery

Autor: Paulus Kirchhof, Rebecca L Woolley, Natalie J Ives, John Stickley, Timothy J Jones, Nigel E Drury, Kevin P Morris, Carin Van Doorn, Rehana Bi, James Montgomerie, Warwick B Dunn, Melanie Madhani

Publikováno v: BMJ Open, Vol 10, Iss 10 (2020)

Introduction Myocardial protection against ischaemic-reperfusion injury is a key determinant of heart function and outcome following cardiac surgery in children. However, with current strategies, myocardial injury occurs routinely following aortic cr

Externí odkaz: https://doaj.org/article/dc3c75aa75d241828e7cdb3112576f31

Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome: the PREDNOS RCT

Autor: Nicholas JA Webb, Rebecca L Woolley, Tosin Lambe, Emma Frew, Elizabeth A Brettell, Emma N Barsoum, Richard S Trompeter, Carole Cummins, Keith Wheatley, Natalie J Ives

Publikováno v: Health Technology Assessment, Vol 23, Iss 26 (2019)

Background: The optimal corticosteroid regimen for treating the presenting episode of steroid-sensitive nephrotic syndrome (SSNS) remains uncertain. Most UK centres use an 8-week regimen, despite previous systematic reviews indicating that longer reg

Externí odkaz: https://doaj.org/article/70b1a7df8be04f38ab82cff77133acb4

Evaluation of Daily Low-Dose Prednisolone During Upper Respiratory Tract Infection to Prevent Relapse in Children With Relapsing Steroid-Sensitive Nephrotic Syndrome: The PREDNOS 2 Randomized Clinical Trial

Autor: Martin T. Christian, Nicholas J. A. Webb, Samir Mehta, Rebecca L. Woolley, Nafsika Afentou, Emma Frew, Elizabeth A. Brettell, Adam R. Khan, David V. Milford, Detlef Bockenhauer, Moin A. Saleem, Angela S. Hall, Ania Koziell, Heather Maxwell, Shivaram Hegde, Hitesh Prajapati, Rodney D. Gilbert, Caroline Jones, Karl McKeever, Wendy Cook, Natalie Ives

Publikováno v: Christian, M T, Webb, N J A, Mehta, S, Woolley, R L, Afentou, N, Frew, E, Brettell, E A, Khan, A R, Milford, D V, Bockenhauer, D, Saleem, M A, Hall, A S, Koziell, A, Maxwell, H, Hegde, S, Prajapati, H, Gilbert, R D, Jones, C, McKeever, K, Cook, W & Ives, N 2021, ' Evaluation of Daily Low-Dose Prednisolone During Upper Respiratory Tract Infection to Prevent Relapse in Children With Relapsing Steroid-Sensitive Nephrotic Syndrome : The PREDNOS 2 Randomized Clinical Trial ', JAMA Pediatrics . https://doi.org/10.1001/jamapediatrics.2021.5189
JAMA Pediatrics

Key Points Question In children with relapsing corticosteroid-sensitive nephrotic syndrome, does daily low-dose corticosteroid given at the time of upper respiratory tract infection prevent upper respiratory tract infection–related relapse? Finding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624ff0a56a1e917664485ed8159ee9c3
https://pubmed.ncbi.nlm.nih.gov/35410970