Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rebecca L. Openshaw"'
Autor:
Rebecca L. Openshaw, David M. Thomson, Greg C. Bristow, Emma J. Mitchell, Judith A. Pratt, Brian J. Morris, Neil Dawson
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Autism spectrum disorders are more common in males, and have a substantial genetic component. Chromosomal 16p11.2 deletions in particular carry strong genetic risk for autism, yet their neurobiological impact is poorly characterised, particu
Externí odkaz:
https://doaj.org/article/a9c33b7142af4f94937b2541091f6e9d
Autor:
Craig K. Docherty, Nina Denver, Simon Fisher, Margaret Nilsen, Dianne Hillyard, Rebecca L. Openshaw, Hicham Labazi, Margaret R. MacLean
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 396-405 (2020)
The 5HT1B receptor (5HT1BR) contributes to the pathogenic effects of serotonin in pulmonary arterial hypertension. Here, we determine the effect of a microRNA96 (miR96) mimic delivered directly to the lungs on development of severe pulmonary hyperten
Externí odkaz:
https://doaj.org/article/e5d263e8dc1b4639b7c47108893f55bc
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 3 (2022)
In schizophrenia, subjects show reduced ability to evaluate and update risk/reward contingencies, showing correspondingly suboptimal performance in the Iowa gambling task. JNK signalling gene variants are associated with schizophrenia risk, and JNK m
Externí odkaz:
https://doaj.org/article/9a76da6a05ce411aafb7551f75a0602d
Autor:
Rebecca L. Openshaw, Jaedeok Kwon, Alison McColl, Josef M. Penninger, Jonathan Cavanagh, Judith A. Pratt, Brian J. Morris
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background Important insight into the mechanisms through which gene-environmental interactions cause schizophrenia can be achieved through preclinical studies combining prenatal immune stimuli with disease-related genetic risk modifications.
Externí odkaz:
https://doaj.org/article/e4491777a70e43c38bdab2c69e8264c6
Autor:
Greg C. Bristow, David M. Thomson, Rebecca L. Openshaw, Emma J. Mitchell, Judith A. Pratt, Neil Dawson, Brian J. Morris
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Chromosome 16p11.2 duplications dramatically increase risk for schizophrenia, but the mechanisms remain largely unknown. Here, we show that mice with an equivalent genetic mutation (16p11.2 duplication mice) exhibit impaired hippocampal-orbi
Externí odkaz:
https://doaj.org/article/7728d8dbc8bd473aafcc7b7820bf4f24
Publikováno v:
Journal of Psychopharmacology (Oxford, England)
Background: Aside from regulating circadian rhythms, melatonin also affects cognitive processes, such as alertness, and modulates the brain circuitry underlying psychiatric diseases, such as depression, schizophrenia and bipolar disorder, via mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0563bec884aa0ca1d392956c7429c798
https://pubmed.ncbi.nlm.nih.gov/34304635
https://pubmed.ncbi.nlm.nih.gov/34304635
Autor:
Margaret R. MacLean, Nina Denver, Rebecca L. Openshaw, Dianne Z. Hillyard, Craig K. Docherty, Margaret Nilsen, Hicham Labazi, Simon Fisher
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 22, Iss, Pp 396-405 (2020)
Molecular Therapy: Nucleic Acids, Vol 22, Iss, Pp 396-405 (2020)
The 5HT1B receptor (5HT1BR) contributes to the pathogenic effects of serotonin in pulmonary arterial hypertension. Here, we determine the effect of a microRNA96 (miR96) mimic delivered directly to the lungs on development of severe pulmonary hyperten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49af2e82db7d961eb98cef09cf0c51a
https://strathprints.strath.ac.uk/75323/1/Docherty_etal_MTNA_2020_Direct_delivery_of_microRNA96_to_the_lungs_reduces_progression.pdf
https://strathprints.strath.ac.uk/75323/1/Docherty_etal_MTNA_2020_Direct_delivery_of_microRNA96_to_the_lungs_reduces_progression.pdf
Autor:
David M. Thomson, Clotilde Mannoury la Cour, Marianna Kouskou, Judith A. Pratt, Rebecca L. Openshaw, Millan Mark, Emma J Mitchell, Brian J. Morris
Publikováno v:
Genes, Brain and Behavior. 20
The GPR88 orphan G protein-coupled receptor is expressed throughout the striatum, being preferentially localised in medium spiny neurons. It is also present in lower densities in frontal cortex and thalamus. Rare mutations in humans suggest a role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9772bb71c17fb72c5733c3738c1a3ccf
https://doi.org/10.1111/gbb.12710
https://doi.org/10.1111/gbb.12710
Autor:
David M. Thomson, Greg Bristow, Emma J. Mitchell, Rebecca L. Openshaw, Neil Dawson, Brian J. Morris, Judith A. Pratt
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
There are no current treatments for autism, despite its high prevalence. Deletions of chromosome 16p11.2 dramatically increase risk for autism, suggesting that mice with an equivalent genetic rearrangement may offer a valuable model for the testing o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee6dc50c4fb92fbe7ce9a2bc053ff32
https://strathprints.strath.ac.uk/73586/1/Mitchell_etal_SR_2020_Drug_responsive_autism_phenotypes.pdf
https://strathprints.strath.ac.uk/73586/1/Mitchell_etal_SR_2020_Drug_responsive_autism_phenotypes.pdf
Autor:
Judith A. Pratt, Jaedeok Kwon, Rebecca L. Openshaw, Brian J. Morris, Josef M. Penninger, Jonathan Cavanagh, Alison McColl
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-11 (2019)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Important insight into the mechanisms through which gene-environmental interactions cause schizophrenia can be achieved through preclinical studies combining prenatal immune stimuli with disease-related genetic risk modifications. Accumula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50112e3d20978cfa213babb32130d1b7
https://strathprints.strath.ac.uk/66857/1/Openshaw_etal_JN_2019_JNK_signalling_mediates_aspects_of_maternal_immune_activation.pdf
https://strathprints.strath.ac.uk/66857/1/Openshaw_etal_JN_2019_JNK_signalling_mediates_aspects_of_maternal_immune_activation.pdf