Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rebecca L. Oberle"'
Autor:
Stephen J. Juzwin, Margaret Gryszkiewicz, Rebecca L. Oberle, Cheng-Pang Hsu, Maria Markowska, Anthony J Streeter
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 46:51-55
Introduction: The aim of this investigation was to evaluate methods for increasing Caco-2 cell throughput for assessing drug intestinal absorption. The use of 6-, 12-, and 24-well membranes and the effect of membrane size on permeability and the inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560de83cfc17f0847060545ce8030b79
https://doi.org/10.1016/s1056-8719(01)00161-7
https://doi.org/10.1016/s1056-8719(01)00161-7
Autor:
Yulia Hirschberg, Nicholas Lowther, Yi Jin, Hanspeter Nick, Roy Fox, Harry Donnelly, Rebecca L. Oberle, Thomas Sergejew, Bernard Faller
Publikováno v:
Pharmaceutical Research. 16:434-440
Purpose. The in vitro and in situ transport of CGP 65015 ((+)-3-hydroxy-1-(2-hydroxyethyl) -2-hydroxyphenyl-methyl-1 H-pyridin-4-one), a novel oral iron chelator, is described. The predictive power of these data in assessing intestinal absorption in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c2de4c1ffa3ccba92be72a0148e8397
https://doi.org/10.1023/a:1018886005136
https://doi.org/10.1023/a:1018886005136
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 33:75-81
Surfactants are one of the most frequently used adjuvants in oral pharmaceutical preparations, used primarily as solubilizers, stabilizers, emulsifiers, and wetting agents. However, surfactants can disrupt normal membrane structure. In this study, la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770ed3342387dc0471d89027eaf20654
https://doi.org/10.1016/1056-8719(94)00060-h
https://doi.org/10.1016/1056-8719(94)00060-h
The influence of the interdigestive migrating myoelectric complex on the gastric emptying of liquids
Autor:
Gordon L. Amidon, Rebecca L. Oberle, Charles W. Lloyd, Chung Owyang, Jeffrey L. Barnett, Tzyy Show Chen, James H. Meyer
Publikováno v:
Gastroenterology. 99:1275-1282
It is unknown how the interdigestive migrating motor complex influences the gastric emptying of liquids. Therefore, the gastric emptying rate of 50- and 200-mL volumes of phenol red solution were measured while monitoring contractile activity. Motor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbbc79503aeb61c0c71e5cbc0a50d93
https://doi.org/10.1016/0016-5085(90)91150-5
https://doi.org/10.1016/0016-5085(90)91150-5
Autor:
Rebecca L. Oberle, Helena Das
Publikováno v:
Pharmaceutical Research. 11:592-594
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a550a15610616d8f7cfc70c7aa0bbcc8
https://doi.org/10.1023/a:1018939204809
https://doi.org/10.1023/a:1018939204809
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 23(1)
Oral bioavailability of highly water-insoluble drugs is often quite limited and variable, requiring the development of improved formulations. Animal models are an essential aspect of the design and testing of such formulations designed to improve abs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a1811466fc3a88519f99ee589f9eff
https://pubmed.ncbi.nlm.nih.gov/8576841
https://pubmed.ncbi.nlm.nih.gov/8576841
Publikováno v:
Journal of pharmaceutical sciences. 75(5)
The bioavailability of enteric coated and plain aspirin tablets was studied in four beagle dogs. Blood sampling for enteric coated tablets was planned with the aid of a radiotelemetric system. The release of aspirin from its dosage form was detected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f1d12a62b233a80d99d7f21b7acfb3
https://pubmed.ncbi.nlm.nih.gov/3735085
https://pubmed.ncbi.nlm.nih.gov/3735085
Autor:
Gordon L. Amidon, Rebecca L. Oberle
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 15(5)
A physiological flow model is presented to account for plasma level double peaks based on cyclical gastric emptying and intestinal motility in the fasted state. Central to the model is the assumption that gastric emptying and intestinal transit rates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaae8d0143f44682f99613d26be551c6
https://pubmed.ncbi.nlm.nih.gov/3694496
https://pubmed.ncbi.nlm.nih.gov/3694496