Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rebecca L. Mellor"'
Autor:
Wandi Zhu, Wei Wang, Paweorn Angsutararux, Rebecca L. Mellor, Lori L. Isom, Jeanne M. Nerbonne, Jonathan R. Silva
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Native myocardial voltage-gated sodium (NaV) channels function in macromolecular complexes comprising a pore-forming (α) subunit and multiple accessory proteins. Here, we investigated the impact of accessory NaVβ1 and NaVβ3 subunits on the functio
Externí odkaz:
https://doaj.org/article/3a1cd7dc535f4598ae819c3d1643d27f
Autor:
Paweorn Angsutararux, Amal K. Dutta, Martina Marras, Carlota Abella, Rebecca L. Mellor, Jingyi Shi, Jeanne M. Nerbonne, Jonathan R. Silva
Publikováno v:
Journal of General Physiology. 155
Voltage-gated sodium (NaV) channels are responsible for the initiation and propagation of action potentials. In the heart, the predominant NaV1.5 α subunit is composed of four homologous repeats (I–IV) and forms a macromolecular complex with multi
Autor:
Tracey O. Hermanstyne, Nien-Du Yang, Daniel Granados-Fuentes, Xiaofan Li, Rebecca L. Mellor, Timothy Jegla, Erik D. Herzog, Jeanne M. Nerbonne
Considerable evidence suggests that day-night rhythms in the functional expression of subthreshold potassium (K+) channels regulate daily oscillations in the rates of spontaneous action potential firing of neurons in the suprachiasmatic nucleus (SCN)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::656ff9144c767f2f52ec43a205a92a24
https://doi.org/10.1101/2023.01.30.526323
https://doi.org/10.1101/2023.01.30.526323
Autor:
Ying-Chun Shih, Kathryn A. Yamada, Kai-Chien Yang, Jing-Yi Nong, Jeanne M. Nerbonne, Chen-Ting Hung, Rebecca L. Mellor, Evelyn M. Kanter, Yan Zhang, Hui-Ju Chen, Shuei-Liong Lin, Chao-Ling Chen, Chau-Chung Wu, Tzu-Han Lee, Chiung-Nien Chen, Yun Fang, Hua-Chi Wang, Yi-Shuan Tseng
Publikováno v:
Circulation Research. 122:1052-1068
Rationale: Cardiac fibrosis plays a critical role in the pathogenesis of heart failure. Excessive accumulation of extracellular matrix (ECM) resulting from cardiac fibrosis impairs cardiac contractile function and increases arrhythmogenicity. Current
Autor:
Jeanne M. Nerbonne, Jonathan G. Seidman, Adam Adenwala, Rebecca L. Mellor, Rocco Hueneke, Christine E. Seidman
Publikováno v:
Journal of Molecular and Cellular Cardiology. 103:93-101
Familial hypertrophic cardiomyopathy (HCM), linked to mutations in myosin, myosin-binding proteins and other sarcolemmal proteins, is associated with increased risk of life threatening ventricular arrhythmias, and a number of animal models have been
Autor:
Rebecca L. Mellor, Tracey O. Hermanstyne, Erik D. Herzog, Jeanne M. Nerbonne, Daniel Granados-Fuentes
Publikováno v:
eNeuro
Rapidly activating and inactivating A-type K+currents (IA) encoded by Kv4.2 and Kv4.3 pore-forming (α) subunits of the Kv4 subfamily are key regulators of neuronal excitability. Previous studies have suggested a role for Kv4.1 α-subunits in regulat
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(47)
In cortical neurons, pore-forming α-subunits of the Kv4 subfamily underlie the fast transient outward K+current (IA). Considerable evidence has accumulated demonstrating specific roles forIAchannels in the generation of individual action potentials
Publikováno v:
Journal of molecular and cellular cardiology. 39(1)
The Kv channel interacting proteins (KChIPs) were identified in a yeast two hybrid screen using the N terminus of Kv4.3 as bait. Previous studies have demonstrated that KChIP2 associates with voltage-gated K(+) (Kv) pore-forming (alpha) subunits of t