Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rebecca L. McCloud"'
Autor:
Andrea G. Shergalis, Violeta L. Marin, David Y. Rhee, Sameera Senaweera, Rebecca L. McCloud, Judith A. Ronau, Charles W. Hutchins, Shaun McLoughlin, Kevin R. Woller, Scott E. Warder, Anil Vasudevan, Justin M. Reitsma
Publikováno v:
ACS Chemical Biology. 18:331-339
Autor:
Ku-Lung Hsu, Keira E. Mahoney, Kun Yuan, Donald F. Hunt, Jeffrey Shabanowitz, Dina L. Bai, Rebecca L. McCloud, Mark M. Ross
Publikováno v:
Anal Chem
Chemical proteomics is widely used for the global investigation of protein activity and binding of small molecule ligands. Covalent probe binding and inhibition are assessed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to gain mole
Autor:
Jeffrey W. Brulet, Emmanuel K. Toroitich, Adam L. Borne, Ku-Lung Hsu, Adam H. Libby, Kun Yuan, Rebecca L. McCloud, Heung Sik Hahm, Anthony M. Ciancone, Timothy B. Ware
Publikováno v:
Nature chemical biology
Covalent probes serve as valuable tools for global investigation of protein function and ligand binding capacity. Despite efforts to expand coverage of residues available for chemical proteomics (e.g. cysteine and lysine), a large fraction of the pro
Autor:
Ettore J. Rastelli, Isabella K. Blanco, Sharon R. Garrott, Nikhil R. Tasker, James C. Burnett, John S. Lazo, Rebecca L. McCloud, Duncan J. Hart, Ku-Lung Hsu, Peter Wipf, Elizabeth R. Sharlow
Publikováno v:
J Pharmacol Exp Ther
Oncogenic protein tyrosine phosphatases (PTPs) are overexpressed in numerous human cancers but they have been challenging pharmacological targets. The emblematic oncogenic PTP4A tyrosine phosphatase family regulates many fundamental malignant process
Autor:
Charles Spivey, Scott M. Seki, Alban Gaultier, Vlad Serbulea, Anthony Fernandez-Castaneda, Nikolas William Hayes, Rebecca L. McCloud, Ku-Lung Hsu, Lelisa Gemta, Dorian A. Rosen, Sarah C. Nanziri, Kacper Posyniak, Timothy N. J. Bullock, Rebecca M. Beiter
Publikováno v:
Sci Signal
Immunometabolism
Immunometabolism
Small molecules that promote the metabolic activity of the pyruvate kinase isoform PKM2, such as TEPP-46 and DASA-58, limit tumorigenesis and inflammation. To understand how these compounds alter T cell function, we assessed their therapeutic activit
Autor:
Ku-Lung Hsu, Kacper Posyniak, Timothy N. J. Bullock, Charles Spivey, Rebecca M. Beiter, Scott M. Seki, Rebecca L. McCloud, Nikolas William Hayes, Lelisa Gemta, Dorian A. Rosen, Alban Gaultier, Anthony Fernandez-Castaneda
Publikováno v:
SSRN Electronic Journal.
T cells play crucial, and perhaps initiating roles in autoimmune diseases like Multiple Sclerosis (MS). Elucidating the mechanisms that regulate inflammatory T cell responses could reveal novel means of modulation of their pathological role. Small mo
Autor:
Ku-Lung Hsu, Adam L Borne, Jeffrey W Brulet, Heung S Hahm, Emmanuel K Toroitich, Adam H Libby, Kun Yuan, Timothy B Ware, Rebecca L McCloud, Anthony M Ciancone
Publikováno v:
The Journal of Immunology. 204:159.44-159.44
Chemoproteomic probes serve as valuable tools to study and perturb protein function on a global scale. Despite advances in methodologies for cysteine and lysine profiling, a large fraction of the human proteome remains inaccessible with current activ
Autor:
Adam L. Borne, Tao Huang, Rebecca L. McCloud, Ku-Lung Hsu, Boobalan Pachaiyappan, Timothy N. J. Bullock
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783030111427
As a major sentinel of adaptive immunity, T cells seek and destroy diseased cells using antigen recognition to achieve molecular specificity. Strategies to block checkpoint inhibition of T cell activity and thus reawaken the patient's antitumor immun
Autor:
Thurl E. Harris, Ku-Lung Hsu, Rebecca L. McCloud, Caroline E. Franks, Sean T. Campbell, Benjamin Purow
Diacylglycerol kinases (DGKs) regulate lipid metabolism and cell signaling through ATP-dependent phosphorylation of diacylglycerol to biosynthesize phosphatidic acid. Selective chemical probes for studying DGKs are currently lacking and are needed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b0da41c8e2f86693ddb06f5dd57629
https://europepmc.org/articles/PMC5771882/
https://europepmc.org/articles/PMC5771882/
Autor:
Ku-Lung Hsu, Adam L. Borne, Jeffrey W. Brulet, Sean T. Campbell, Caroline E. Franks, Tao Huang, Rebecca L. McCloud, Myungsun Shin, Timothy B. Ware
Publikováno v:
The Journal of Immunology. 202:71.7-71.7
Lipid phosphorylation is an understudied regulatory mechanism for T cell metabolism and signaling. Specifically, diacylglycerol kinases (DGKs) modulate intracellular levels of the secondary messengers diacylglycerol and phosphatidic acid, which are i