Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Rebecca L. Maglathlin"'
Autor:
Edward B. Holson, Timothy A. Lewis, Florence F. Wagner, Stuart L. Schreiber, Bridget K. Wagner, Alicia J. Tang, Danny Hung-Chieh Chou, Rebecca L. Maglathlin
Publikováno v:
Chemistry & Biology. 19(6):669-673
Cytokine-induced beta-cell apoptosis is important to the etiology of type-1 diabetes. Although previous reports have shown that general inhibitors of histone deacetylase (HDAC) activity, such as suberoylanilide hydroxamic acid and trichostatin A, can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f213fdcb3009326aef585ce4b450a3b
Autor:
Wen-Ning Zhao, Peter S. Klein, Timothy A. Lewis, Krista M. Hennig, Rebecca L. Maglathlin, Surya A. Reis, Ralph Mazitschek, Stephen J. Haggarty, Balaram Ghosh, Stephanie Norton, Daniel M. Fass, Rishita Shah
Publikováno v:
ACS Medicinal Chemistry Letters. 2:39-42
Carboxylic acids with known central nervous system and histone deacetylase (HDAC) inhibitory activities were converted to hydroxamic acids and tested using a suite of in vitro biochemical assays with recombinant HDAC isoforms, cell based assays in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9675246d390447ae784c860f1881365
https://doi.org/10.1021/ml1001954
https://doi.org/10.1021/ml1001954
Autor:
D. R. Mani, Karl R. Clauser, Andrew L. Kung, Bina Julian, Massimo Loda, Ingo K. Mellinghoff, Jinyan Du, Todd R. Golub, Paula Bernasconi, David N. Louis, Phioanh L. Nghiemphu, Xiao P. Peng, Timothy A. Lewis, Haley Hieronymus, Rameen Beroukhim, Rebecca L. Maglathlin, Melissa A. Burns, Linda M. Liau, Steven A. Carr, Stephen P. Finn
Publikováno v:
Nature Biotechnology. 27:77-83
The aberrant activation of tyrosine kinases represents an important oncogenic mechanism, and yet the majority of such events remain undiscovered. Here we describe a bead-based method for detecting phosphorylation of both wild-type and mutant tyrosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1437e0ad0edbd7354c9596014a1c7993
https://doi.org/10.1038/nbt.1513
https://doi.org/10.1038/nbt.1513
Publikováno v:
ChemBioChem. 4:272-276
Lanthanide-binding tags (LBTs) are protein fusion partners consisting of encoded amino acids that bind lanthanide ions with high affinity. Herein, we present a new screening methodology for the identification of new LBT sequences with high affinity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a744ab2eb04d6f9e72e05b9893d4426
https://doi.org/10.1002/cbic.200390047
https://doi.org/10.1002/cbic.200390047
Autor:
Morten Frödin, Rand M. Miller, Miles A. Pufall, Katarzyna Duda, Rebecca L. Maglathlin, Michael S. Cohen, Iana M. Serafimova, Shyam Krishnan, Jack Taunton, Jesse M. McFarland
Publikováno v:
Nature chemical biology
Targeting noncatalytic cysteine residues with irreversible acrylamide-based inhibitors is a powerful approach for enhancing pharmacological potency and selectivity. Nevertheless, concerns about off-target modification motivate the development of reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32929b4bd7e25a90bf6557ad560c6764
https://pubmed.ncbi.nlm.nih.gov/22466421
https://pubmed.ncbi.nlm.nih.gov/22466421
Autor:
Sara Imarisio, Stuart L. Schreiber, Cahir J. O'Kane, Rebecca L Maglathlin, Sandra Pineau, Timothy A. Lewis, Ethan O. Perlstein, Axelle Cordenier, Sovan Sarkar, David C. Rubinsztein, John A Webster
Publikováno v:
Nature chemical biology. 3(6)
The target of rapamycin proteins regulate various cellular processes including autophagy, which may play a protective role in certain neurodegenerative and infectious diseases. Here we show that a primary small-molecule screen in yeast yields novel s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b35d1aae75984a27b53387313446b25
https://pubmed.ncbi.nlm.nih.gov/17510644
https://pubmed.ncbi.nlm.nih.gov/17510644
Autor:
Yazmin P. Carrasco, Rebecca L. Maglathlin, Ana Ruiz-Saenz, Mark M. Moasser, Jack Taunton, Manbir Sandhu
Publikováno v:
Cancer Research. 75:2635-2635
There is increasing evidence implicating HER3 in several types of cancer, as a resilient copartner for HER2 in HER2-amplified cancers, and as a driver of resistance in many other types of cancer. However, the development of targeted therapies to inac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8999b0a857fe57d7208497e9f5bd58f2
https://doi.org/10.1158/1538-7445.am2015-2635
https://doi.org/10.1158/1538-7445.am2015-2635
Autor:
Alana G. Lerner, Rebecca L. Maglathlin, Eric Lowe, Jack Taunton, Shirin Arastu-Kapur, Christopher J. Kirk
Publikováno v:
Blood. 122:4439-4439
Multiple myeloma (MM) is the result of deregulated proliferation in malignant plasma cells that secrete an overabundance of a monoclonal immunoglobulin (Ig). The high level of Ig production in MM cells places a unique burden on the ubiquitin proteaso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b74a392536f241ea1bf5b4d342e952d
https://doi.org/10.1182/blood.v122.21.4439.4439
https://doi.org/10.1182/blood.v122.21.4439.4439
Autor:
Bina Julian, Andrew L. Kung, Jinyan Du, Todd R. Golub, Phioanh L. Nghiemphu, Timothy A. Lewis, Frank He, Paula Bernasconi, Kenneth N. Ross, Stephen P. Finn, Xiao Peng, Rameen Beroukhim, Rebecca L. Maglathlin, Karl R. Clauser, Steven A. Carr, Ingo K. Mellinghoff, Melissa Burns, D. R. Mani, Linda M. Liau, Haley Hieronymus, David N. Louis, Adam Margolin, Massimo Loda
Publikováno v:
Cancer Research. 70:5559-5559
Tyrosine kinases (TKs) are frequently, aberrantly activated in human cancers. Moreover, they could be easily inhibited by small molecules and thereby represent excellent therapeutic targets. Here, our project aims to systematically identify activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe90a2353dd4bb6b10a7cba0c23f553
https://doi.org/10.1158/1538-7445.am10-5559
https://doi.org/10.1158/1538-7445.am10-5559
Publikováno v:
ChemBioChem. 4:241-241
The cover picture shows the chemistry and biology used to develop a new protein labeling strategy based on lanthanide-binding peptides. Focused peptide libraries are screened to identify oligopeptide motifs of dual function: the peptides bind TbIII w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdca3da9e68c9bde20e330c47472b615
https://doi.org/10.1002/cbic.200390042
https://doi.org/10.1002/cbic.200390042