Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Rebecca L. Fitzsimmons"'
Autor:
Manuel A. Fernández-Rojo, Milena Gongora, Rebecca L. Fitzsimmons, Nick Martel, Sheree D. Martin, Susan J. Nixon, Andrew J. Brooks, Maria P. Ikonomopoulou, Sally Martin, Harriet P. Lo, Stephen A. Myers, Christina Restall, Charles Ferguson, Paul F. Pilch, Sean L. McGee, Robin L. Anderson, Michael J. Waters, John F. Hancock, Sean M. Grimmond, George E.O. Muscat, Robert G. Parton
Publikováno v:
Cell Reports, Vol 4, Iss 2, Pp 238-247 (2013)
Caveolae and caveolin-1 (CAV1) have been linked to several cellular functions. However, a model explaining their roles in mammalian tissues in vivo is lacking. Unbiased expression profiling in several tissues and cell types identified lipid metabolis
Externí odkaz:
https://doaj.org/article/626b24aa557c4a558809186d6302745e
Autor:
Peiqi Wang, Timothy A. Hill, Justin Mitchell, Rebecca L. Fitzsimmons, Weijun Xu, Zhixuan Loh, Jacky Y. Suen, Junxian Lim, Abishek Iyer, David P. Fairlie
Publikováno v:
Journal of Medicinal Chemistry. 65:11759-11775
Glucagon-like peptide-1 (GLP-1) lowers blood glucose by inducing insulin but also has other poorly understood properties. Here, we show that hydroxy amino acids (Thr11, Ser14, Ser17, Ser18) in GLP-1(7-36) act in concert to direct cell signaling. Muta
Autor:
Matthew J. Sweet, Abishek Iyer, David P. Fairlie, Elizabeth E. Powell, Zhixuan Loh, Robert Reid, Rebecca L. Fitzsimmons, Divya Ramnath, Jennifer L. Stow, Kate Schroder, Katharine M. Irvine, Andrew D. Clouston, Praveer Gupta
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Chronic liver diseases feature excessive collagen and matrix protein deposition or crosslinking that characterises fibrosis, leads to scar tissue, and disrupts liver functions. There is no effective treatment. This study inves
A cell culture platform for quantifying metabolic substrate oxidation in bicarbonate-buffered medium
Publikováno v:
Journal of Biological Chemistry. 298:101547
Complex diseases such as cancer and diabetes are underpinned by changes in metabolism, specifically by which and how nutrients are catabolized. Substrate utilization can be directly examined by measuring a metabolic endpoint rather than an intermedia
Autor:
Matthew J. Sweet, Elizabeth E. Powell, Robert Reid, Divya Ramnath, Kate Schroder, Rebecca L. Fitzsimmons, Katharine M. Irvine, Abishek Iyer, Jennifer L. Stow, Zhixuan Loh, David P. Fairlie, Andrew D. Clouston
Publikováno v:
The FASEB Journal. 33
Autor:
Gary Cowin, George E.O. Muscat, Zewen K. Tuong, Michael A. Pearen, Gethin P. Thomas, Rebecca L. Fitzsimmons, S.-C. Mary Wang, Natalie A. Eriksson, Joel M. Goode
Publikováno v:
Molecular Endocrinology. 27:1897-1917
The mRNA encoding Nor-1/NR4A3 is rapidly and strikingly induced by β2-adrenergic signaling in glycolytic and oxidative skeletal muscle. In skeletal muscle cells, Nor-1 expression is important for the regulation of oxidative metabolism. Transgenic sk
Autor:
Andrew J. Brooks, Christina Restall, Manuel A. Fernandez-Rojo, Susan J. Nixon, Sally Martin, Maria P. Ikonomopoulou, Nick Martel, Harriet P. Lo, Robin L. Anderson, Sean L. McGee, John F. Hancock, Michael J. Waters, Rebecca L. Fitzsimmons, Paul F. Pilch, George E.O. Muscat, Sheree D. Martin, Sean M. Grimmond, Milena Gongora, Charles Ferguson, Stephen Myers, Robert G. Parton
Publikováno v:
Cell Reports, Vol 4, Iss 2, Pp 238-247 (2013)
SummaryCaveolae and caveolin-1 (CAV1) have been linked to several cellular functions. However, a model explaining their roles in mammalian tissues in vivo is lacking. Unbiased expression profiling in several tissues and cell types identified lipid me
Autor:
Shu Ching Mary Wang, Tae Gyu Oh, Patrick Lau, George E.O. Muscat, Zewen K. Tuong, Frederik J. Steyn, Gethin P. Thomas, Rebecca L. Fitzsimmons
Publikováno v:
EBioMedicine
EBioMedicine, Vol 11, Iss C, Pp 101-117 (2016)
EBioMedicine, Vol 11, Iss C, Pp 101-117 (2016)
RORα is a member of the nuclear receptor (NR) superfamily and analysis of the (global) RORα-deficient mouse model revealed this NR has a role in glycemic control and fat deposition. Therefore, we generated an adipose-specific RORα ‘gain of funct
Autor:
George E.O. Muscat, Michael A. Pearen, Nick Martel, Joel M. Goode, Sofianos Andrikopoulos, Rebecca L. Fitzsimmons, Natalie A. Eriksson
Publikováno v:
Molecular Endocrinology. 26:372-384
Nuclear hormone receptors (NR) have been implicated as regulators of lipid and carbohydrate metabolism. The orphan NR4A subgroup has emerged as regulators of metabolic function. Targeted silencing of neuron-derived orphan receptor 1 (Nor-1)/NR4A3 in
Autor:
Shu-Ching Mary Wang, Suryaprakash Raichur, Natalie A. Eriksson, Patrick Lau, Stephen Myers, Rebecca L. Fitzsimmons, George E.O. Muscat, Michael A. Pearen
Publikováno v:
Nucleic Acids Research
The retinoic acid receptor-related orphan receptor (ROR) alpha has been demonstrated to regulate lipid metabolism. We were interested in the ROR alpha 1 dependent physiological functions in skeletal muscle. This major mass organ accounts for approxim