Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rebecca L. Edelstein"'
Autor:
Marisa L. Hovlid, Corey Strickland, Joshua D. Ochocki, Alan Hruza, Fernando López-Gallego, Nicholas P. Labello, Mark D. Distefano, Claudia Schmidt-Dannert, Olivier Henry, Victor G. Young, Rebecca L. Edelstein, Stepan Lenevich, Amanda J. DeGraw, Trista Talbot
Publikováno v:
Chemical Biology & Drug Design. 75:51-67
Photoactive analogs of farnesyl diphosphate (FPP) are useful probes in studies of enzymes that employ this molecule as a substrate. Here, we describe the preparation and properties of two new FPP analogs that contain diazotrifluoropropanoyl photophor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467b05142dd622acf09deeea5227b013
https://doi.org/10.1111/j.1747-0285.2009.00914.x
https://doi.org/10.1111/j.1747-0285.2009.00914.x
Autor:
Tammy C. Turek, Satinder K. Singh, Rebecca L. Edelstein, Valerie A. Weller, Igor Gaon, Mark D. Distefano
Publikováno v:
The Journal of Organic Chemistry. 61:7738-7745
Farnesyl pyrophosphate (FPP) is involved in a large number of cellular processes including the prenylation of transforming mutants of Ras proteins implicated in cancer. Photoactive analogs could provide useful information about enzyme active sites th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cd2c2ae805b7cc6260ecfdf1441cee
https://doi.org/10.1021/jo9602736
https://doi.org/10.1021/jo9602736
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b485cd23d63b8553d1734bc98d79a7c
https://doi.org/10.1002/chin.199848266
https://doi.org/10.1002/chin.199848266
Publikováno v:
Biochemistry. 40(13)
Protein geranylgeranyltransferase type I (PGGTase-I) catalyzes the nucleophilic substitution reaction between the C(20) geranylgeranyl diphosphate (GGPP) and a protein-derived thiol to form a thioether linkage. Here, we describe the stereochemical ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f746a9530589334d94118c7d8ae87256
https://pubmed.ncbi.nlm.nih.gov/11300771
https://pubmed.ncbi.nlm.nih.gov/11300771
Publikováno v:
Biochemical and biophysical research communications. 235(2)
Farnesyl protein transferase (FPTase) catalyzes the covalent attachment of a farnesyl (C 15 ) group from farnesyl pyrophosphate (FPP) to a specific cysteine residue of Ras and several other proteins. In this report, photoactive farnesyl and geranylge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176674d3d22efa0b5699d4f3770ff9ae
https://pubmed.ncbi.nlm.nih.gov/9199201
https://pubmed.ncbi.nlm.nih.gov/9199201