Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rebecca L. Davie"'
Autor:
Edward P. Feener, Rebecca L. Davie, Nivetha Murugesan, Stephen J. Pethen, Sally L. Hampton, Michael D. Smith, Paul K. Audhya, Chris M. Yea
Publikováno v:
Drugs and Drug Candidates, Vol 3, Iss 2, Pp 328-341 (2024)
Sebetralstat is a novel, potent, and selective oral plasma kallikrein inhibitor drug candidate in clinical development for the on-demand treatment of hereditary angioedema (HAE). Upon binding, sebetralstat induces a conformational change in the activ
Externí odkaz:
https://doaj.org/article/c898ea85087542009c61e6fcd2741b8b
Autor:
Rebecca L. Davie, Hannah J. Edwards, D. Michael Evans, Simon T. Hodgson, Michael J. Stocks, Alun J. Smith, Louise J. Rushbrooke, Stephen J. Pethen, Michael B. Roe, David E. Clark, Paul A. McEwan, Sally L. Hampton
Publikováno v:
Journal of medicinal chemistry. 65(20)
Hereditary angioedema (HAE) is a rare genetic disorder in which patients experience sudden onset of swelling in various locations of the body. HAE is associated with uncontrolled plasma kallikrein (PKa) enzyme activity and generation of the potent in
Publikováno v:
Tetrahedron. 61:2335-2351
Investigation of the intramolecular Diels–Alder reactions of 6-fumaryl 1,3,8-nonatrienes, substituted at the C5 by a vinyl group, to afford the B-ring of FR182877 are reported. The synthesis of the required 1,3,8-nonatriene was achieved quickly and
Publikováno v:
Tetrahedron Letters. 43:2753-2756
6-Fumaryl 1,3,8-nonatrienes substituted at the C 5 position by a vinyl group were found to undergo competing tandem sigmatropic rearrangement/Diels–Alder cyclisation when heated under standard Diels–Alder cyclisation conditions. This rearrangemen
Autor:
Yongda Zhu, George D. Becker, Holly M. Christenson, Anson D’Aloisio, Sarah E. I. Bosman, Tom Bakx, Valentina D’Odorico, Manuela Bischetti, Christopher Cain, Frederick B. Davies, Rebecca L. Davies, Anna-Christina Eilers, Xiaohui Fan, Prakash Gaikwad, Martin G. Haehnelt, Laura C. Keating, Girish Kulkarni, Samuel Lai, Hai-Xia Ma, Andrei Mesinger, Yuxiang Qin, Sindhu Satyavolu, Tsutomu T. Takeuchi, Hideki Umehata, Jinyi Yang
Publikováno v:
The Astrophysical Journal, Vol 955, Iss 2, p 115 (2023)
The mean free path of ionizing photons, λ _mfp , is a critical parameter for modeling the intergalactic medium (IGM) both during and after reionization. We present direct measurements of λ _mfp from QSO spectra over the redshift range 5 < z < 6, in
Externí odkaz:
https://doaj.org/article/598d97dba9064e05a6e4de4028082ba7