Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rebecca L. Bigler"'
Autor:
Tharkika Nagendran, Rylan S. Larsen, Rebecca L. Bigler, Shawn B. Frost, Benjamin D. Philpot, Randolph J. Nudo, Anne Marion Taylor
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Spinal cord injury can induce synaptic reorganization and remodeling in the brain. Here the authors study how severed distal axons signal back to the cell body to induce hyperexcitability, loss of inhibition and enhanced presynaptic release through n
Externí odkaz:
https://doaj.org/article/1f87dabee91b461a89a2e1999bf53396
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The identification of mRNAs in distal projections of model organisms has led to the discovery of multiple proteins that are locally synthesized for functional roles such as axon guidance, injury signaling and regeneration. The extent to whic
Externí odkaz:
https://doaj.org/article/f44e3cec4ede4ee5a6138c9055d581d4
Autor:
Shawn B. Frost, Rylan S. Larsen, Tharkika Nagendran, Randolph J. Nudo, Anne Marion Taylor, Rebecca L. Bigler, Benjamin D. Philpot
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Injury of CNS nerve tracts remodels circuitry through dendritic spine loss and hyper-excitability, thus influencing recovery. Due to the complexity of the CNS, a mechanistic understanding of injury-induced synaptic remodeling remains unclear. Using m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb85ba07b52b737c6f98ad792a430c95
https://doi.org/10.1038/s41467-017-00652-y
https://doi.org/10.1038/s41467-017-00652-y
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
The identification of mRNAs in distal projections of model organisms has led to the discovery of multiple proteins that are locally synthesized for functional roles such as axon guidance, injury signaling and regeneration. The extent to which local p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f44da94f3def441ae86c8ee535ebe7c
https://doi.org/10.1038/s41598-017-00676-w
https://doi.org/10.1038/s41598-017-00676-w
The identification of axonal mRNAs in model organisms has led to the discovery of multiple proteins synthesized within axons for functional roles such as axon guidance and injury response. The extent to which protein synthesis within the axon is cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ec24e061357e39308dc0ab14c876e9
https://doi.org/10.1101/066142
https://doi.org/10.1101/066142
Autor:
Robert E. Rhoads, Wei Su, Stacie Meaux, William F. Marzluff, Michael K. Slevin, Rebecca L. Bigler, Joshua D. Welch, Paula L. Miliani de Marval, Jan F. Prins
Publikováno v:
Molecular cell. 53(6)
Summary Histone mRNAs are rapidly degraded when DNA replication is inhibited during S phase with degradation initiating with oligouridylation of the stem loop at the 3′ end. We developed a customized RNA sequencing strategy to identify the 3′ ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16509a7d8b958870970d738a11cbb326
https://pubmed.ncbi.nlm.nih.gov/24656133
https://pubmed.ncbi.nlm.nih.gov/24656133
Autor:
Scott J. Bultman, Rebecca L. Bigler, Leonard B. Collins, Dallas R. Donohoe, Wei Sun, Aminah Wali
Widespread changes in gene expression drive tumorigenesis, yet our knowledge of how aberrant epigenomic and transcriptome profiles arise in cancer cells is poorly understood. Here, we demonstrate that metabolic transformation plays an important role.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318effc197ee3e6ecc69a542d61c4fc3
Autor:
Zefeng Wang, Caleb Cassidy-Amstutz, Chunhua Li, Rebecca L. Bigler, Traci M. Tanaka Hall, Shuyun Dong, Gang Lu, Mark R. Jezyk, Yang Wang
Pumilio/fem-3 mRNA-binding factor (PUF) proteins possess a recognition code for bases A, U, and G, allowing designed RNA sequence specificity of their modular Pumilio (PUM) repeats. However, recognition side chains in a PUM repeat for cytosine are un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e0c77770e585d90d1de3f1438a9a9c
https://europepmc.org/articles/PMC3144504/
https://europepmc.org/articles/PMC3144504/