Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Rebecca L Vartuli"'
Autor:
Lingdi Zhang, Hengbo Zhou, Xueni Li, Rebecca L Vartuli, Michael Rowse, Yongna Xing, Pratyaydipta Rudra, Debashis Ghosh, Rui Zhao, Heide L Ford
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Eya proteins are characterised by phosphatase activity associated with both the evolutionary conserved region and the less conserved N-terminal domain (NTD). Here the authors show that NTD mediates the interaction with PP2A and regulates c-Myc phosph
Externí odkaz:
https://doaj.org/article/e85d17f3da1b488cb955698e3352b45c
Autor:
Melanie Y. Vincent, Jared Klarquist, Rebecca L. Vartuli, Rui Zhao, Rani K. Powers, Debashis Ghosh, Pratyaydipta Rudra, James C. Costello, Ross M. Kedl, Heide L. Ford, Hengbo Zhou, Jill E. Slansky, Lingdi Zhang
Publikováno v:
Journal of Clinical Investigation. 128:2535-2550
Eya proteins are critical developmental regulators that are highly expressed in embryogenesis but downregulated after development. Amplification and/or re-expression of Eyas occurs in many tumor types. In breast cancer, Eyas regulate tumor progressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf542bc016bb20744b06ca5d6295ba4a
https://doi.org/10.1172/jci96784
https://doi.org/10.1172/jci96784
Autor:
Pratyaydipta Rudra, Xueni Li, Yongna Xing, Debashis Ghosh, Lingdi Zhang, Rebecca L. Vartuli, Rui Zhao, Hengbo Zhou, Michael Rowse, Heide L. Ford
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Eya genes encode a unique family of multifunctional proteins that serve as transcriptional co-activators and as haloacid dehalogenase-family Tyr phosphatases. Intriguingly, the N-terminal domain of Eyas, which does not share sequence similarity to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1a9bc5b0fd7918a1c16f1ba304655f
https://doaj.org/article/e85d17f3da1b488cb955698e3352b45c
https://doaj.org/article/e85d17f3da1b488cb955698e3352b45c
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 96:165-170
The Eya proteins were originally identified as essential transcriptional co-activators of the Six family of homeoproteins. Subsequently, the highly conserved C-terminal domains of the Eya proteins were discovered to act as a Mg(2+)-dependent Tyr phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d26208e91781d35e8674264df1f2e4
https://doi.org/10.1016/j.biocel.2017.09.001
https://doi.org/10.1016/j.biocel.2017.09.001
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 127:105847
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d253deee0bf48e64325af64ae7941a71
https://doi.org/10.1016/j.biocel.2020.105847
https://doi.org/10.1016/j.biocel.2020.105847
Autor:
Joaquín M. Espinosa, Zdenek Andrysik, E. S. Linklater, Ahwan Pandey, Heide L. Ford, David J. Drasin, Anna L. Guarnieri, Michael U.J. Oliphant, Rebecca L. Vartuli, Taylor J. Hotz, Santosh Khanal, Christina G. Towers
Publikováno v:
Oncogene
Tumor initiating cells (TIC) represent a subset of tumor cells with increased self-renewal capability. TICs display resistance to frontline cancer treatment and retain the ability to repopulate a tumor after therapy, leading to cancer relapse. NOTCH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcf2937f54d49f116f24385df11b23f
https://pubmed.ncbi.nlm.nih.gov/29662198
https://pubmed.ncbi.nlm.nih.gov/29662198
Autor:
Anna L Smith, Douglas S. Micalizzi, Aik Choon Tan, David J. Drasin, Rebecca L. Vartuli, Ritsuko Iwanaga, Heide L. Ford
Publikováno v:
Oncogene
The role of TGF-β signaling in tumorigenesis is paradoxical: it can be tumor suppressive or tumor promotional, depending on context. The metastatic regulator, Six1, was recently shown to mediate this switch, providing a novel means to explain this e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd26d4f2e2d4a4149c125619859fb9cb
https://doi.org/10.1038/onc.2012.11
https://doi.org/10.1038/onc.2012.11
Autor:
Heide L. Ford, Lingdi Zhang, Michael Rowse, Hengbo Zhou, Rui Zhao, Pratyaydipta Rudra, Yongna Xing, Rebecca L. Vartuli, Debashis Ghosh, Xueni Li
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications
Nature Communications
Eya genes encode a unique family of multifunctional proteins that serve as transcriptional co-activators and as haloacid dehalogenase-family Tyr phosphatases. Intriguingly, the N-terminal domain of Eyas, which does not share sequence similarity to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11070f25a34142b757b29da0d841a11f
https://doaj.org/article/01f8112d1c1445b7aa67d2d545f6604b
https://doaj.org/article/01f8112d1c1445b7aa67d2d545f6604b
Publikováno v:
European Journal of Cancer. 48:125
J.M. Vernier, D. Matthews, P. Pearson, S. Hershenson, J. Freddo, A.J. Giaccia, R. Tabibiazar, P.M. O’Connor. Ruga Corporation, Chemistry, Palo Alto California, USA; Ruga Corporation, Crystallography, Palo Alto California, USA; Ruga Corporation, Pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d588d3a2d8e7bbbb0666f2312ba38f81
https://doi.org/10.1016/s0959-8049(12)72209-8
https://doi.org/10.1016/s0959-8049(12)72209-8
Autor:
Heide L. Ford, Ritsuko Iwanaga, Rebecca L. Vartuli, Anna L. Smith, David J. Drasin, Douglas S. Micalizzi
Publikováno v:
Cancer Research. 72:A20-A20
Recent studies have highlighted the developmental transcription factor Six1 as an important mediator of breast cancer progression and metastasis. Six1 is overexpressed in a striking 90% of metastatic breast cancer lesions, and patients whose tumors o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f322a60c13608b17ba79cd3ee87756c
https://doi.org/10.1158/1538-7445.nonrna12-a20
https://doi.org/10.1158/1538-7445.nonrna12-a20