Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rebecca L Kow"'
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95922 (2014)
Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy. Activation of muscarinic receptors has been previously shown to increase the production of endocannabinoids in the brain. E
Externí odkaz:
https://doaj.org/article/6e59de0ade6740f5b72f979e1d0b9b88
Autor:
Cindy L Reiner, Jennifer S McCullar, Rebecca L Kow, Joshua H Le, David R Goodlett, Neil M Nathanson
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13517 (2010)
Receptor internalization from the cell surface occurs through several mechanisms. Some of these mechanisms, such as clathrin coated pits, are well understood. The M(2) muscarinic acetylcholine receptor undergoes internalization via a poorly-defined c
Externí odkaz:
https://doaj.org/article/7856ad320ed747b7b8858e16a60c3b68
Autor:
Rebecca L. Kow, Timothy J. Strovas, Pamela J. McMillan, Ashley M. Jacobi, Mark A. Behlke, Aleen D. Saxton, Caitlin S. Latimer, C. Dirk Keene, Brian C. Kraemer
Publikováno v:
Neurobiology of Disease, Vol 147, Iss , Pp 105148- (2021)
Aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like Alzheimer's disease. Previously we showed loss of function mutations in the gene encoding the poly(A) RNA binding protein SUT-2/MSUT2 su
Externí odkaz:
https://doaj.org/article/a306260c5f1f44a8881453e339558866
Publikováno v:
GeroScience
Neurodegenerative diseases with tau pathology, or tauopathies, include Alzheimer’s disease and related dementia disorders. Previous work has shown that loss of the poly(A) RNA-binding protein gene sut-2/MSUT2 strongly suppressed tauopathy in Caenor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fd0d9f1751664ad0fe32d782191df0
https://doi.org/10.1007/s11357-022-00526-2
https://doi.org/10.1007/s11357-022-00526-2
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The pathological accumulation of the microtubule binding protein tau drives age-related neurodegeneration in a variety of disorders, collectively called tauopathies. In the most common tauopathy, Alzheimer’s disease (AD), the accumulation of pathol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3fa93fbfcc698a12d5b31af0ad6fe0
https://doi.org/10.1073/pnas.2207250120
https://doi.org/10.1073/pnas.2207250120
Autor:
Pamela J. McMillan, Aleen D. Saxton, Mark A. Behlke, Timothy J. Strovas, Rebecca L. Kow, Brian C. Kraemer, Ashley M. Jacobi, C. Dirk Keene, Caitlin S. Latimer
Publikováno v:
Neurobiology of disease
Neurobiology of Disease, Vol 147, Iss, Pp 105148-(2021)
Neurobiology of Disease, Vol 147, Iss, Pp 105148-(2021)
Aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like Alzheimer's disease. Previously we showed loss of function mutations in the gene encoding the poly(A) RNA binding protein SUT-2/MSUT2 su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231b90f0f8921e9852fbc349ef8dbabd
https://pubmed.ncbi.nlm.nih.gov/33184027
https://pubmed.ncbi.nlm.nih.gov/33184027
Publikováno v:
Biological Psychiatry. 83:438-446
Background The microtubule-associated protein tau accumulates into toxic aggregates in multiple neurodegenerative diseases. We found previously that loss of D2-family dopamine receptors ameliorated tauopathy in multiple models including a Caenorhabdi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868b8596f6d50e830ff7fa37e896987a
https://doi.org/10.1016/j.biopsych.2017.06.007
https://doi.org/10.1016/j.biopsych.2017.06.007
Autor:
Timothy J. Strovas, Aleen D. Saxton, C. Dirk Keene, Gerard D. Schellenberg, Chris R. Guthrie, Brian C. Kraemer, John Q. Trojanowski, Pamela J. McMillan, Linda C. Robinson, Nicholas M. Kanaan, Murray A. Raskind, Jeanna M. Wheeler, Li-San Wang, Nicole F. Liachko, Elaine R. Peskind, Patricia Szot, Virginia M.-Y. Lee, Thomas D. Bird, Rebecca L. Kow, Alexandre Amlie-Wolf, Ronald Klein
Publikováno v:
Sci Transl Med
Brain lesions composed of pathological tau help to drive neurodegeneration in Alzheimer’s disease (AD) and related tauopathies. Here, we identified the mammalian suppressor of tauopathy 2 (MSUT2) gene as a modifier of susceptibility to tau toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6425183692ee7e471b8d16fef6fc2f
https://doi.org/10.1126/scitranslmed.aao6545
https://doi.org/10.1126/scitranslmed.aao6545
Autor:
Jennifer Stewart, Don B Sanders, Neha Patel, Preeti Sharma, Lisa Mullen, Maria T Britto, Raouf S Amin, Stacy Bichl, Michael Powers, Martina Compton, Rhonda List, Dana Albon, Hossein Sadeghi, Clement Ren, Prigi Varghese, Pornchai Tirakitsoontorn, Maivy Sou, Golnar Raissi, Bean Corcoran, George Solomon, Bethany Jablonski Horton, Shiyi Shen, Christopher Siracusa, Kimberly Hodges, Shontae Hill, Kristen Ameel, Sarah Dykes, Johanna Zea-Hernandez Ben McCullar, Courtney Roberts, Elisabeth Debri, Dana Goodwin, Juliana Bailey, George Soloman, Erin Newbill, Misty Thompson, Rebecca L Kowal, Danielle Poulin, Cori L Daines, Glenda A Drake, David C Miller
Publikováno v:
BMJ Open Quality, Vol 12, Iss 4 (2023)
Introduction Cystic fibrosis (CF) is a systemic autosomal recessive condition characterised by progressive lung disease. CF pulmonary exacerbations (PEx) are episodes of worsening respiratory status, and frequent PEx are a risk factor for accelerated
Externí odkaz:
https://doaj.org/article/a153842b63fd4129bdccf236583a8006
Publikováno v:
Biochemistry. 48:9801-9809
Dihydroorotate dehydrogenases (DHODs) are FMN-containing enzymes that catalyze the conversion of dihydroorotate (DHO) to orotate in the de novo synthesis of pyrimidines. During the reaction, a proton is transferred from C5 of DHO to an active site ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317f8dbc1cf4b8418ea5d838dd341943
https://doi.org/10.1021/bi901024m
https://doi.org/10.1021/bi901024m