Výsledky vyhledávání - "Rebecca L Dryer"

Maintenance of the CD40-related immunodeficient response in hyper-IgM B cells immortalized with a LMP1-regulated mini-EBV

Autor: Kristina T. Lu, Rebecca L. Dryer, Charles H. Song, Lori R. Covey

Publikováno v: Journal of Leukocyte Biology. 78:620-629

Our previous investigation of a patient (pt1) with non-X-linked hyper-immunoglobulin M syndrome revealed a CD40-mediated defect in B cell activation that resulted in low CD23 expres- sion and absence of germ-line transcription and class-switch recomb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5702e9c40b9032525007c00cb24df8f2
https://doi.org/10.1189/jlb.0305159

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c-Rel plays a key role in deficient activation of B cells from a non-X-linked hyper-IgM patient

Autor: Charles H. Song, Frank L. Sinquett, Lori R. Covey, Kristina T. Lu, Rebecca L. Dryer

Publikováno v: Blood. 108(12)

Our previous results demonstrated that B cells from a patient (pt1) with non–X-linked hyper-IgM syndrome (HIGM) possess an atypical CD23lo phenotype that is unaffected by CD40-mediated activation. To investigate the molecular mechanism underlying d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412312081d1f911a9ca919d16d1d7bd3
https://pubmed.ncbi.nlm.nih.gov/16896156

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A novel NF-kappa B-regulated site within the human I gamma 1 promoter requires p300 for optimal transcriptional activity

Autor: Lori R. Covey, Rebecca L. Dryer

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 175(7)

Transcriptional activation of germline (GL) promoters occurs through binding of NF-κB to three evolutionarily conserved sites within a CD40 response region in the human and mouse GL Iγ and Iε promoters. Here we identify and characterize a novel NF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b26eaca7949e8c4e2c5a8c8ae6d4f9
https://pubmed.ncbi.nlm.nih.gov/16177093

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Single Nucleotide Variations Between the I gamma 1 and I gamma 4 Promoters Result in Biased Recruitment of Transcription Factors in Response to CD40 Signaling (35.7)

Autor: Frank L Sinquett, Rebecca L Dryer, Lori R Covey

Publikováno v: The Journal of Immunology. 178:S2-S3

IgG subclass expression is highly biased in human IgM+ B cells activated with CD40L and IL-4. This bias is clearly reflected at the level of germline (Iγ) transcription despite extensive homology throughout the four Iγ promoters. Our current aim is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2bf56faf52604e639e3e0e3f48e100e
https://doi.org/10.4049/jimmunol.178.supp.35.7

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Use of chromatin immunoprecipitation (chip) to detect transcription factor binding to highly homologous promoters in chromatin isolated from unstimulated and activated primary human B cells

Autor: Lori R. Covey, Rebecca L. Dryer

Publikováno v: Biological Procedures

The Chromatin Immunoprecipiation (ChIP) provides a powerful technique for identifying the in vivo association of transcription factors with regulatory elements. However, obtaining meaningful information for promoter interactions is extremely challeng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1090f93a4b7442cb2c0c8b8982bbc4

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