Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Rebecca L, Skalsky"'
Autor:
Benjamin D. Varco-Merth, William Brantley, Alejandra Marenco, Derick D. Duell, Devin N. Fachko, Brian Richardson, Kathleen Busman-Sahay, Danica Shao, Walter Flores, Kathleen Engelman, Yoshinori Fukazawa, Scott W. Wong, Rebecca L. Skalsky, Jeremy Smedley, Michael K. Axthelm, Jeffrey D. Lifson, Jacob D. Estes, Paul T. Edlefsen, Louis J. Picker, Cheryl M.A. Cameron, Timothy J. Henrich, Afam A. Okoye
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Proliferation of latently infected CD4+ T cells with replication-competent proviruses is an important mechanism contributing to HIV persistence during antiretroviral therapy (ART). One approach to targeting this latent cell expansion is to inhibit mT
Externí odkaz:
https://doaj.org/article/0626fdc3092c4cc489640700d2cf76b5
Publikováno v:
mSphere, Vol 6, Iss 2 (2021)
EBV is a human pathogen associated with several malignancies. A key aspect of lifelong virus persistence is the ability to switch between latent and lytic replication modes.
Externí odkaz:
https://doaj.org/article/d3965c4c42f94dd780bd32190645d6f5
Autor:
Mickaël Bouvet, Stefanie Voigt, Takanobu Tagawa, Manuel Albanese, Yen-Fu Adam Chen, Yan Chen, Devin N. Fachko, Dagmar Pich, Christine Göbel, Rebecca L. Skalsky, Wolfgang Hammerschmidt
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Acute antiviral functions of all nucleated cells rely on type I interferon (IFN-I) pathways triggered upon viral infection. Host responses encompass the sensing of incoming viruses, the activation of specific transcription factors that induce the tra
Externí odkaz:
https://doaj.org/article/5df41ff7727d458eb1c5cf6678139f31
Publikováno v:
PLoS Pathogens, Vol 15, Iss 1, p e1007535 (2019)
MicroRNAs (miRNAs) are post-transcriptional regulatory RNAs that can modulate cell signaling and play key roles in cell state transitions. Epstein-Barr virus (EBV) expresses >40 viral miRNAs that manipulate both viral and cellular gene expression pat
Externí odkaz:
https://doaj.org/article/c46320767218461b81cd6606cda1da1c
Publikováno v:
Pathogens, Vol 10, Iss 2, p 200 (2021)
Human cytomegalovirus (HCMV) encodes 22 mature microRNAs (miRNAs), which regulate a myriad of cellular processes, including vesicular trafficking, cell cycle progression, apoptosis, and immune evasion, as well as viral gene expression. Recent evidenc
Externí odkaz:
https://doaj.org/article/060b0c51ba27490082881f372da7d040
Autor:
Rebecca L Skalsky
Publikováno v:
Current opinion in virology. 56
Herpesviruses, such as Epstein-Barr virus (EBV), encode multiple viral microRNAs that are expressed throughout various infection stages. While much progress has been made in evaluating both the viral and host microRNAs (miRNAs) that are detected duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09f31fea6164658a733cb9f51d00613
https://pubmed.ncbi.nlm.nih.gov/36242893
https://pubmed.ncbi.nlm.nih.gov/36242893
Autor:
Rebecca L. Skalsky, Scott W. Wong, Derick M. Duell, Lina Gao, Richard Lum, Michael K. Axthelm, Audrie L. Konfe, Maren Q. DeGottardi, Afam A. Okoye, Devin N. Fachko, Mukta Vaidya, He Li, Byung Park, Louis J. Picker, Yoshinori Fukazawa, Chike O. Abana, Jeffrey D. Lifson, Anne D. Lewis
Publikováno v:
J Immunol
Although IL-15 has been implicated in the pathogenic hyperimmune activation that drives progressive HIV and SIV infection, as well as in the generation of HIV/SIV target cells, it also supports NK and T cell homeostasis and effector activity, potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8261ffa4e55bdea0264c899e1f0609d
https://doi.org/10.4049/jimmunol.1900792
https://doi.org/10.4049/jimmunol.1900792
Publikováno v:
J Virol
Journal of virology, vol 96, iss 4
Journal of virology, vol 96, iss 4
Suppression of lytic viral gene expression is a key aspect of the Epstein-Barr virus (EBV) life cycle to facilitate the establishment of latent infection. Molecular mechanisms regulating transitions between EBV lytic replication and latency are not f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b7c19615586f886a22efbdc98cc6d0
https://pubmed.ncbi.nlm.nih.gov/34878852
https://pubmed.ncbi.nlm.nih.gov/34878852
EBV BART MicroRNAs Target Multiple Pro-apoptotic Cellular Genes to Promote Epithelial Cell Survival.
Publikováno v:
PLoS Pathogens, Vol 11, Iss 6, p e1004979 (2015)
Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus that can give rise to cancers of both B-cell and epithelial cell origin. In EBV-induced cancers of epithelial origin, including nasopharyngeal carcinomas (NPCs) and gastric carcinomas, the
Externí odkaz:
https://doaj.org/article/2dce997bc8bf4ade8423bbc44733d706
Publikováno v:
mSphere, vol 6, iss 2
mSphere, Vol 6, Iss 2 (2021)
mSphere
mSphere, Vol 6, Iss 2 (2021)
mSphere
Antigen recognition by the B cell receptor (BCR) is a physiological trigger for reactivation of Epstein-Barr virus (EBV) and can be recapitulated in vitro by cross-linking of surface immunoglobulins. Previously, we identified a subset of EBV microRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b652feffc451698a6270f406b960899
https://escholarship.org/uc/item/48q777sp
https://escholarship.org/uc/item/48q777sp
