Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Rebecca L, Ross"'
Autor:
Masahiro Kondo, Tsuyoshi Suzuki, Yuko Kawano, Shinji Kojima, Masahiko Miyashiro, Atsuhiro Matsumoto, Gabriela Kania, Przemysław Błyszczuk, Rebecca L. Ross, Panji Mulipa, Francesco Del Galdo, Yun Zhang, Jörg H. W. Distler
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-17 (2022)
Abstract Background Activation of melanocortin 1 receptor (MC1R) is known to exert broad anti-inflammatory and anti-fibrotic effects. The purpose of this study is to investigate the potential of dersimelagon, a novel oral MC1R agonist, as a therapeut
Externí odkaz:
https://doaj.org/article/4359e25614b54dcda62a5b4e9a9fd00b
Autor:
Christopher W. Wasson, Rebecca L. Ross, Rebecca Wells, Clarissa Corinaldesi, Ioanna Ch. Georgiou, Natalia A. Riobo-Del Galdo, Francesco Del Galdo
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-15 (2020)
Abstract Objectives Systemic sclerosis (SSc) is characterised by tissue fibrosis of the major organs of the body including the skin, lungs and heart. We have previously reported that the lncRNA HOTAIR plays a central role in the activation of SSc myo
Externí odkaz:
https://doaj.org/article/183b5f5be4e0494eacc1b87be0018035
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Systemic sclerosis (SSc) is a terminal disease characterized by vasculopathy, tissue fibrosis, and autoimmunity. Although the exact etiology of SSc remains unknown, endothelial dysfunction, oxidative stress, and calcium handling dysregulation have be
Externí odkaz:
https://doaj.org/article/60184fa03e5e442cbd2e8ca07b86cc95
Autor:
Kulveer Mankia, Paul Emery, Lesley-Anne Bissell, Brendan Clarke, Darren Newton, Rebecca L Ross, Laurence Duquenne, Benazir Saleem, Aamir Aslam, Pam Hughes, Diane Corsadden, Clive Carter, Fatima A Nadat, Panji Mulipa, Mark Lobb, Katie Mbara, Ruth Morton, Sophie Dibb, Rahaymin Chowdhury, Alexandra Pike, Vishal Kakkar, Sinisia Savic, Francesco DelGaldo
Publikováno v:
RMD Open, Vol 8, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/5dde514756a244ce8e1b853f8feac6a2
Autor:
Paul Mellor, Jeremy D. S. Marshall, Xuan Ruan, Dielle E. Whitecross, Rebecca L. Ross, Margaret A. Knowles, Stanley A. Moore, Deborah H. Anderson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract The p85α protein regulates flux through the PI3K/PTEN signaling pathway, and also controls receptor trafficking via regulation of Rab-family GTPases. In this report, we determined the impact of several cancer patient-derived p85α mutations
Externí odkaz:
https://doaj.org/article/623db4a84b7e4de981307ebca5478389
Publikováno v:
Rheumatology. 62
Background/Aims Activation of Type I IFN response has been shown to be present in blood and tissue in systemic sclerosis (SSc) and correlates with disease pathogenesis and therapy response. It is currently unknown whether the tissue-specific Type I I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35eb27aa78a48ba42901b2cf96ed37be
https://doi.org/10.1093/rheumatology/kead104.202
https://doi.org/10.1093/rheumatology/kead104.202
Autor:
Rebecca L Ross, Emily Clarke, Will Merchant, Ioanna Georgiou, Panji Mulipa, Antonio Carriero, Giuseppina Abignano, Ariane Herrick, Christopher Denton, Natalia Riobo-Del Galdo, Francesco Del Galdo
Publikováno v:
Rheumatology. 62
Background/Aims The VEDOSS study has recently indicated that more than 50% of patients affected by Raynaud’s phenomenon (RP) and specific SSc anti-nuclear antibodies (ANA) and/or nailfold videocapillaroscopy changes (NVC) (sRP) satisfied ACR/EULAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81f5e9290b8258f2f83c7df2ee594d49
https://doi.org/10.1093/rheumatology/kead104.203
https://doi.org/10.1093/rheumatology/kead104.203
Autor:
Christopher. W. Wasson, Eva. M. Clavane, Rebecca. L. Ross, Gemma Migneco, Cristina Antinozzi, Jane. M. Y. Brown, Luigi Di Luigi, Clive. S. McKimmie, Francesco Del Galdo, Paul. J. Meakin
BackgroundThe beta-amyloid precursor protein cleaving enzyme 1 (BACE1) is well known for its role in the development of Alzheimer’s disease via the generation of β-amyloid. Recent publications, including our own, have demonstrated a role for this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65c1f79584eb3b2ec24beeb008fbb637
https://doi.org/10.1101/2022.12.22.521579
https://doi.org/10.1101/2022.12.22.521579
Autor:
Christopher W. Wasson, Jörg H W Distler, Clarissa Corinaldesi, Rebecca L. Ross, Agne Antanaviciute, Clive S. McKimmie, Francesco Del Galdo, Yasser M. El-Sherbiny, Steve Holmes, Antonio Carriero, Ian M. Carr, Gemma Migneco
Publikováno v:
Annals of the Rheumatic Diseases
ObjectivesPlasmacytoid dendritic cells (pDC) have been implicated in the pathogenesis of autoimmune diseases, such as scleroderma (SSc). However, this has been derived from indirect evidence using ex vivo human samples or mouse pDC in vivo. We have d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473d00b640768e601885c487760a3d7b
https://doi.org/10.1136/annrheumdis-2020-218439
https://doi.org/10.1136/annrheumdis-2020-218439
Publikováno v:
Rheumatology. 60:4395-4400
Objectives Tissue fibrosis in SSc is driven by active fibroblasts (myofibroblasts). Previous studies have shown the intracellular chloride channel 4 (CLIC4) mediates the activation of cancer-associated fibroblasts. In this study we investigated the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1915ca016fe16e405eaecf4e49aaa71
https://doi.org/10.1093/rheumatology/keaa797
https://doi.org/10.1093/rheumatology/keaa797