Dedicated transcriptomics combined with power analysis lead to functional understanding of genes with weak phenotypic changes in knockout lines.

Autor: Chen Xie, Cemalettin Bekpen, Sven Künzel, Maryam Keshavarz, Rebecca Krebs-Wheaton, Neva Skrabar, Kristian K Ullrich, Wenyu Zhang, Diethard Tautz

Publikováno v: PLoS Computational Biology, Vol 16, Iss 11, p e1008354 (2020)

Systematic knockout studies in mice have shown that a large fraction of the gene replacements show no lethal or other overt phenotypes. This has led to the development of more refined analysis schemes, including physiological, behavioral, development

Externí odkaz: https://doaj.org/article/93edf5c01752499cb64f7661299546e7

Author Reply to Peer Reviews of Natural copy number differences of tandemly repeated small nucleolar RNAs in the Prader-Willi syndrome genomic region regulate individual behavioral responses in mammals

Autor: Diethard Tautz, Elisabeth B. Binder, Tanja M. Brückl, Anja Guenther, Yi Zhang, Yoland Savriama, Peter Refki, Rebecca Krebs-Wheaton, Maryam Keshavarz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8de6d99496d7a5de61549ede05ee41e
https://doi.org/10.15252/rc.2022980552

Studying the dawn of de novo gene emergence in mice reveals fast integration of new genes into functional networks

Autor: Chen Xie, Kristian K. Ullrich, Maryam Keshavarz, Diethard Tautz, Neva Skrabar, Sven Künzel, Rebecca Krebs-Wheaton, Cemalettin Bekpen

The de novo emergence of new transcripts has been well documented through genomic analyses. However, a functional analysis, especially of very young protein-coding genes, is still largely lacking. Here we focus on three loci that have evolved from pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3ffbc4cfcb30e83fe1bf616591580f
https://doi.org/10.1101/510214

Tracing reinforcement through asymmetrical partner preference in the European common vole Microtus arvalis

Autor: Mathias Beysard, Gerald Heckel, Rebecca Krebs-Wheaton

Publikováno v: Beysard, Mathias; Krebs-Wheaton, Rebecca; Heckel, Gerald (2015). Tracing reinforcement through asymmetrical partner preference in the European common vole Microtus arvalis. BMC evolutionary biology, 15(1) BioMed Central 10.1186/s12862-015-0455-5
BMC Evolutionary Biology

Background The mechanistic basis of speciation and in particular the contribution of behaviour to the completion of the speciation process is often contentious. Contact zones between related taxa provide a situation where selection against hybridizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107481811ec9f22ff5d6448328d2bec6