Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Rebecca Konietzny"'
Autor:
Aysegul Sapmaz, Ilana Berlin, Erik Bos, Ruud H. Wijdeven, Hans Janssen, Rebecca Konietzny, Jimmy J. Akkermans, Ayse E. Erson-Bensan, Roman I. Koning, Benedikt M. Kessler, Jacques Neefjes, Huib Ovaa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Though ubiquitin is known to broadly influence endosomal trafficking, few ubiquitin-utilizing enzymes targeting endosomal regulators are known. Here, the authors find that the deubiquitylating enzyme (DUB) USP32 influences endosomal membrane dynamics
Externí odkaz:
https://doaj.org/article/03097ad9b5bc4f32abfc5298bf844d05
Autor:
Cyriel S. Olie, Muhammad Riaz, Rebecca Konietzny, Philip D. Charles, Adan Pinto-Fernandez, Szymon M. Kiełbasa, A. Aartsma-Rus, Jelle J. Goeman, Benedikt M. Kessler, Vered Raz
Publikováno v:
iScience, Vol 12, Iss , Pp 318-332 (2019)
Summary: Reduced poly(A)-binding protein nuclear 1 (PABPN1) levels cause aging-associated muscle wasting. PABPN1 is a multifunctional regulator of mRNA processing. To elucidate the molecular mechanisms causing PABPN1-mediated muscle wasting, we compa
Externí odkaz:
https://doaj.org/article/5dae7c2a66fa4fae87860ea79e03a0f4
A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes
Autor:
Tianyi Zhang, Guifeng Wei, Christopher J. Millard, Roman Fischer, Rebecca Konietzny, Benedikt M. Kessler, John W. R. Schwabe, Neil Brockdorff
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Transcription regulation requires recruitment of different epigenetic regulators to the chromatin. Here the authors provide evidence that an H3K36me3 reader PWWP2A forms a variant NuRD complex and plays a role in regulating transcription and histone
Externí odkaz:
https://doaj.org/article/5054f4fdda3244658206c728b04b321a
Autor:
Shonagh Munro, Edward S. Hookway, Melanie Floderer, Simon M. Carr, Rebecca Konietzny, Benedikt M. Kessler, Udo Oppermann, Nicholas B. La Thangue
Publikováno v:
Cell Reports, Vol 19, Iss 11, Pp 2193-2201 (2017)
The retinoblastoma tumor suppressor protein pRb is a master regulator of cellular proliferation, principally through interaction with E2F and regulation of E2F target genes. Here, we describe the H1.2 linker histone as a major pRb interaction partner
Externí odkaz:
https://doaj.org/article/ee5d94d2d69c46e49403b4c9d84fd915
Autor:
Emilia Dimitrova, Takashi Kondo, Angelika Feldmann, Manabu Nakayama, Yoko Koseki, Rebecca Konietzny, Benedikt M Kessler, Haruhiko Koseki, Robert J Klose
Publikováno v:
eLife, Vol 7 (2018)
CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells
Externí odkaz:
https://doaj.org/article/e1ac4beed4eb453a8c6554167bc7f70f
Autor:
Sabine Brandt, Maik Blissenbach, Bastian Grewe, Rebecca Konietzny, Thomas Grunwald, Klaus Uberla
Publikováno v:
PLoS Pathogens, Vol 3, Iss 4, p e54 (2007)
The main function attributed to the Rev proteins of immunodeficiency viruses is the shuttling of viral RNAs containing the Rev responsive element (RRE) via the CRM-1 export pathway from the nucleus to the cytoplasm. This restricts expression of struc
Externí odkaz:
https://doaj.org/article/f4d9bb65b1074ef59c7a4c6030630c10
Autor:
Anne E. Kiltie, Benedikt M. Kessler, Martin Kerr, Rebecca Konietzny, Sophie Ellermann, Blaz Groselj, Sarah J. Jevons, Judith Nicholson
Supplemental figures 1-5: S1 - Identification of MRE11 truncation by mass spectrometry and western blot quantification from Fig 1A. S2 - Western blots of protein levels after chloroquine treatment and densitometry of MRE11 levels after PAN and cycloh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6191f00590a10b1ad275359899ebe480
https://doi.org/10.1158/0008-5472.22414497
https://doi.org/10.1158/0008-5472.22414497
Autor:
Anne E. Kiltie, Benedikt M. Kessler, Martin Kerr, Rebecca Konietzny, Sophie Ellermann, Blaz Groselj, Sarah J. Jevons, Judith Nicholson
The MRE11/RAD50/NBS1 (MRN) complex mediates DNA repair pathways, including double-strand breaks induced by radiotherapy. Meiotic recombination 11 homolog (MRE11) is downregulated by histone deacetylase inhibition (HDACi), resulting in reduced levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f35da1633447ff87b420157ed1fe5091
https://doi.org/10.1158/0008-5472.c.6508998.v1
https://doi.org/10.1158/0008-5472.c.6508998.v1
Autor:
Hans Janssen, Ilana Berlin, Rebecca Konietzny, Roman I. Koning, Benedikt M. Kessler, Jacques Neefjes, Erik Bos, Ayse Elif Erson-Bensan, Jimmy J. Akkermans, Aysegul Sapmaz, Huib Ovaa, Ruud H. Wijdeven
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nature Communications, 10
Nature Communications
Nature Communications, 10
The endosomal system is a highly dynamic multifunctional organelle, whose complexity is regulated in part by reversible ubiquitylation. Despite the wide-ranging influence of ubiquitin in endosomal processes, relatively few enzymes utilizing ubiquitin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5fcaf619a90fb0ff123872cdd7f12a
https://doaj.org/article/03097ad9b5bc4f32abfc5298bf844d05
https://doaj.org/article/03097ad9b5bc4f32abfc5298bf844d05
Autor:
Susanne Müller, Stefan Knapp, Rebecca Konietzny, Cynthia Tallant, Eidarus Salah, Sebastian Mathea, Benedikt M. Kessler, Benedict-Tilman Berger, Deep Chatterjee
Publikováno v:
The Biochemical journal. 478(14)
The human protein kinase ULK3 regulates the timing of membrane abscission, thus being involved in exosome budding and cytokinesis. Herein, we present the first high-resolution structures of the ULK3 kinase domain. Its unique features are explored aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d80d3a4ce299446a54fcc3380e9dd9
https://pubmed.ncbi.nlm.nih.gov/34190988
https://pubmed.ncbi.nlm.nih.gov/34190988