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pro vyhledávání: '"Rebecca K. Nguyen"'
Autor:
Chaitali P. Basole, Rebecca K. Nguyen, Katie Lamothe, Puja Billis, Mai Fujiwara, Amanda G. Vang, Robert B. Clark, Paul M. Epstein, Stefan Brocke
Publikováno v:
Cells, Vol 11, Iss 4, p 660 (2022)
After decades of development, inhibitors targeting cyclic nucleotide phosphodiesterases (PDEs) expressed in leukocytes have entered clinical practice for the treatment of inflammatory disorders, with three PDE4 inhibitors being in clinical use as the
Externí odkaz:
https://doaj.org/article/5055b40788c0466f94ca1126e1336b9f
Autor:
Amanda G. Vang, Hongli Dong, Rebecca K. Nguyen, Chaitali Basole, William Housley, Linda Guernsey, Alexander J Adami, Roger Thrall, Robert Bennett Clark, Paul Mark Epstein, Stefan Brocke
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell function. The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs). We have previ
Externí odkaz:
https://doaj.org/article/82e5b1b86644445094c0cedf375bcb71
Autor:
Chaitali P, Basole, Rebecca K, Nguyen, Katie, Lamothe, Amanda, Vang, Robert, Clark, George S, Baillie, Paul M, Epstein, Stefan, Brocke
Publikováno v:
Cellular signalling. 40
The levels of cAMP are regulated by phosphodiesterase enzymes (PDEs), which are targets for the treatment of inflammatory disorders. We have previously shown that PDE8 regulates T cell motility. Here, for the first time, we report that PDE8A exerts p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c17f9ba12ff8b2ecd475ae1f4861f043
https://pubmed.ncbi.nlm.nih.gov/28851628
https://pubmed.ncbi.nlm.nih.gov/28851628