Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Rebecca K. Martin"'
Autor:
Anuj Tharakan, Daniel Rodriguez-Agudo, Sheela Damle, Genta Kakiyama, William M. Pandak, Gregorio Gil, Rebecca K. Martin
Publikováno v:
Biochemistry and Biophysics Reports, Vol 40, Iss , Pp 101873- (2024)
StarD5 is an ER stress protein that binds cholesterol and transfers it to the plasma membrane. It additionally binds and regulates 25-hydroxycholesterol (25-HC) levels. However the full function of the StarD5-25-HC axis is unknown. 25-HC has been rec
Externí odkaz:
https://doaj.org/article/425909eb7685452699ca098fa65a991c
Autor:
Luigi Marino, Bin Ni, Jared S. Farrar, Joseph C. Lownik, Janina V. Pearce, Rebecca K. Martin, Francesco S. Celi
Publikováno v:
Adipocyte, Vol 13, Iss 1 (2024)
ABSTRACTA Disintegrin And Metalloproteinase domain-containing protein 10 (ADAM10), is involved in several metabolic and inflammatory pathways. We speculated that ADAM10 plays a modulatory role in adipose tissue inflammation and metabolism. To this en
Externí odkaz:
https://doaj.org/article/ca0aa1675b914de79d66fe6633e60097
Autor:
Debolina D. Biswas, Rebecca K. Martin, LaShardai N. Brown, Karli Mockenhaupt, Angela S. Gupta, Michael J. Surace, Anuj Tharakan, Jessie W. Yester, Reetika Bhardwaj, Daniel H. Conrad, Tomasz Kordula
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background Immune activation, neuroinflammation, and cell death are the hallmarks of multiple sclerosis (MS), which is an autoimmune demyelinating disease of the central nervous system (CNS). It is well-documented that the cellular inhibitor
Externí odkaz:
https://doaj.org/article/6c833ed3cee3440db1a9c38026d20d4d
Autor:
Yetirajam Rajesh, Saranya Chidambaranathan Reghupaty, Rachel G. Mendoza, Debashri Manna, Indranil Banerjee, Mark A. Subler, Korri Weldon, Zhao Lai, Shah Giashuddin, Paul B. Fisher, Arun J. Sanyal, Rebecca K. Martin, Mikhail G. Dozmorov, Jolene J. Windle, Devanand Sarkar
Publikováno v:
Hepatology Communications, Vol 6, Iss 3, Pp 561-575 (2022)
Obesity is an enormous global health problem, and obesity‐induced nonalcoholic steatohepatitis (NASH) is contributing to a rising incidence and mortality for hepatocellular carcinoma (HCC). Increase in de novo lipogenesis and decrease in fatty acid
Externí odkaz:
https://doaj.org/article/68bca182ccdc45e18434f8976822db49
Autor:
Jared S. Farrar, Joseph C. Lownik, Grayson W. Way, Matthew C. Rodriguez, Francesco S. Celi, Rebecca K. Martin
Publikováno v:
Adipocyte, Vol 10, Iss 1, Pp 91-100 (2021)
The Adipoq-Cre transgenic mouse is widely used in the development of adipocyte-specific genetic manipulations for the study of obesity and type 2 diabetes. In the process of developing a new mouse model utilizing the adipocyte selective Adipoq-Cre tr
Externí odkaz:
https://doaj.org/article/d2fcfa7102594f03a2d1117be7e6ed78
Autor:
Andrea J. Luker, Laura J. Graham, Timothy M. Smith, Carmen Camarena, Matt P. Zellner, Jamie-Jean S. Gilmer, Sheela R. Damle, Daniel H. Conrad, Harry D. Bear, Rebecca K. Martin
Publikováno v:
BMC Immunology, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background Myeloid derived suppressor cells (MDSCs) present a significant obstacle to cancer immunotherapy because they dampen anti-tumor cytotoxic T cell responses. Previous groups, including our own, have reported on the myelo-depletive ef
Externí odkaz:
https://doaj.org/article/8705275c0da24e8995eee5018ccbc1c7
Publikováno v:
Adipocyte, Vol 9, Iss 1, Pp 509-522 (2020)
The role of ADAM17, its substrates, and its natural inhibitor has been well studied in the context of inflammation, including metabolic inflammation, with mixed results. Previous studies examining global Adam17 knockdown models and ADAM17 inhibition
Externí odkaz:
https://doaj.org/article/eb8e21319c094f31a8bf17549bb15568
Publikováno v:
Biochemistry and Biophysics Reports, Vol 24, Iss , Pp 100803- (2020)
The role of the inducible costimulatory of T cells (ICOS) has been shown to be important for many different T cell outcomes and is indispensable for follicular helper T cell (TFH) responses. Since its discovery, there have been several studies on the
Externí odkaz:
https://doaj.org/article/3a93e54c42254dd89bdb7d19618c9f85
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Generating inhibitors for ADisintegrin And Metalloproteinase 10 (ADAM10), a zinc-dependent protease, was heavily invested in by the pharmaceutical industry starting over 20 years ago. There has been much enthusiasm in basic research for these inhibit
Externí odkaz:
https://doaj.org/article/19750701edf34e1eb8ff3720ae65f34d
Autor:
Ryan S. Green, Waheeda A. Naimi, Lee D. Oliver, Nathaniel O’Bier, Jaehyung Cho, Daniel H. Conrad, Rebecca K. Martin, Richard T. Marconi, Jason A. Carlyon
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Diverse intracellular pathogens rely on eukaryotic cell surface disulfide reductases to invade host cells. Pharmacologic inhibition of these enzymes is cytotoxic, making it impractical for treatment. Identifying and mechanistically dissectin
Externí odkaz:
https://doaj.org/article/5fcfb0454aa64878b57f1f16d651b6f8