Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Rebecca K Holloway"'
Autor:
Katie J Smith, Danielle Minns, Brian J McHugh, Rebecca K Holloway, Richard O'Connor, Anna Williams, Lauren Melrose, Rhoanne McPherson, Veronique E Miron, Donald J Davidson, Emily Gwyer Findlay
Publikováno v:
PLoS Biology, Vol 20, Iss 8, p e3001554 (2022)
Multiple sclerosis (MS) is a highly prevalent demyelinating autoimmune condition; the mechanisms regulating its severity and progression are unclear. The IL-17-producing Th17 subset of T cells has been widely implicated in MS and in the mouse model,
Externí odkaz:
https://doaj.org/article/6092c03798ea4893825a68dc61de5313
The polarity protein Scribble regulates myelination and remyelination in the central nervous system.
Autor:
Andrew A Jarjour, Amanda Boyd, Lukas E Dow, Rebecca K Holloway, Sandra Goebbels, Patrick O Humbert, Anna Williams, Charles ffrench-Constant
Publikováno v:
PLoS Biology, Vol 13, Iss 3, p e1002107 (2015)
The development and regeneration of myelin by oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), requires profound changes in cell shape that lead to myelin sheath initiation and formation. Here, we demonstrate a requirem
Externí odkaz:
https://doaj.org/article/66807c3dc1214268828929b4e77180c2
Autor:
Irene Molina-Gonzalez, Rebecca K. Holloway, Zoeb Jiwaji, Owen Dando, Sarah A. Kent, Katie Emelianova, Amy F. Lloyd, Lindsey H. Forbes, Ayisha Mahmood, Thomas Skripuletz, Viktoria Gudi, James A. Febery, Jeffrey A. Johnson, Jill H. Fowler, Tanja Kuhlmann, Anna Williams, Siddharthan Chandran, Martin Stangel, Andrew J. M. Howden, Giles E. Hardingham, Veronique E. Miron
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Failed regeneration of myelin around neuronal axons following central nervous system damage contributes to nerve dysfunction and clinical decline in various neurological conditions, for which there is an unmet therapeutic demand. Here, we sh
Externí odkaz:
https://doaj.org/article/c24c9e61819a48939d2ddccda235b862
Autor:
Rebecca K. Holloway, Liang Zhang, Irene Molina-Gonzalez, Kathy Ton, James A. R. Nicoll, James P. Boardman, Yan Liang, Anna Williams, Veronique E. Miron
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract Myelination of neuronal axons is a critical aspect of central nervous system development and function. However, the fundamental cellular and molecular mechanisms influencing human developmental myelination and its failure are not fully under
Externí odkaz:
https://doaj.org/article/34498bae4a64448fac233d5ac8f7924e
Autor:
Marco Massimo, Carlotta Barelli, Catalina Moreno, Chiara Collesi, Rebecca K Holloway, Berta Crespo, Lorena Zentilin, Anna Williams, Veronique E Miron, Mauro Giacca, Katherine R Long
Publikováno v:
Brain. 146:1175-1185
Maternal viral infection and immune response are known to increase the risk of altered development of the foetal brain. Given the ongoing global pandemic of coronavirus disease 2019 (COVID-19), investigating the impact of SARS-CoV-2 on foetal brain h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3d4eb8654241057c5e6acab9b4516c
https://doi.org/10.1093/brain/awac372
https://doi.org/10.1093/brain/awac372
Autor:
Niamh B. McNamara, David A. D. Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F. J. Bogie, Alana Hoffmann, Rebecca K. Holloway, Irene Molina-Gonzalez, Katharine E. Askew, Stephen Mitchell, William Mungall, Michael Dodds, Carsten Dittmayer, Jonathan Moss, Jamie Rose, Stefan Szymkowiak, Lukas Amann, Barry W. McColl, Marco Prinz, Tara L. Spires-Jones, Werner Stenzel, Karen Horsburgh, Jerome J. A. Hendriks, Clare Pridans, Rieko Muramatsu, Anna Williams, Josef Priller, Veronique E. Miron
Publikováno v:
Nature 613(7942), 120-129 (2023). doi:10.1038/s41586-022-05534-y
Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that support myelin health are unclear. Although macrophages in the central nervous system have been implicated in myelin health1, it is unknown w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228d404a8611c8450df3d12b1580b5c6
Autor:
Irene Molina-Gonzalez, Rebecca K. Holloway, Zoeb Jiwaji, Owen Dando, Katie Emelianova, Amy F. Lloyd, Lindsey H. Forbes, Ayisha Mahmood, Thomas Skripuletz, Viktoria Gudi, James A. Febery, Jeffrey A. Johnson, Jill H. Fowler, Tanja Kuhlmann, Anna Williams, Siddharthan Chandran, Martin Stangel, Andrew J.M. Howden, Giles E. Hardingham, Veronique E. Miron
SummaryFailed regeneration of myelin around neuronal axons following central nervous system damage contributes to nerve dysfunction and clinical decline in various neurological conditions, for which there is an unmet therapeutic demand1,2. Here, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38eb1083540b581d5917ed6649a4fea8
https://doi.org/10.1101/2022.10.04.510850
https://doi.org/10.1101/2022.10.04.510850
Autor:
Katie J. Smith, Danielle Minns, Brian J. McHugh, Rebecca K. Holloway, Richard O’Connor, Anna Williams, Lauren Melrose, Rhoanne McPherson, Veronique E. Miron, Donald J. Davidson, Emily Gwyer Findlay
Publikováno v:
Smith, K, Minns, D, McHugh, B, Holloway, R, O'Connor, R A, Williams, A C, Melrose, L, McPherson, R, Miron, V E, Davidson, D J & Gwyer Findlay, E L 2022, ' The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation ', PLoS Biology . https://doi.org/10.1371/journal.pbio.3001554
Multiple sclerosis (MS) is a highly prevalent demyelinating autoimmune condition; the mechanisms regulating its severity and progression are unclear. The IL-17-producing Th17 subset of T cells has been widely implicated in MS and in the mouse model,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177cf162efca07578b4796b727daf078
https://www.pure.ed.ac.uk/ws/files/297738163/journal.pbio.3001554.pdf
https://www.pure.ed.ac.uk/ws/files/297738163/journal.pbio.3001554.pdf
Autor:
Julie-Clare Becher, Colin Smith, Gemma Sullivan, Rebecca K. Holloway, Veronique E. Miron, James P. Boardman, Pierre Gressens, Graeme Ireland
Publikováno v:
Glia
Injury to the developing brain during the perinatal period often causes hypomyelination, leading to clinical deficits for which there is an unmet therapeutic need. Dysregulation of inflammation and microglia have been implicated, yet the molecular me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699bd0df348f97e6fa1fdc9f9856069b
https://doi.org/10.1002/glia.23963
https://doi.org/10.1002/glia.23963
Autor:
Amélie Montané, Vincent Degos, Rebecca K. Holloway, Valérie C. Besson, Olivier Baud, David H. Rowitch, Pierre Gressens, A. David Edwards, Rahma Hassan-Abdi, Henrik Hagberg, Bobbi Fleiss, Nadia Soussi-Yanicostas, Sophie Lebon, Enrico Petretto, Gareth Ball, Tifenn Le Charpentier, Fabrice Chrétien, Andrée Delahaye-Duriez, Olivier Hennebert, Zsolt Csaba, Paul Aljabar, Anne-Laure Schang, Alka Saxena, Juliette Van Steenwinckel, Veronique E. Miron, Michelle L. Krishnan, Stéphanie Sigaut, Claire Leconte, Franck Verdonk, Cindy Bokobza, Leslie Schwendimann, Walter Birchmeier
Publikováno v:
Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2019, 42 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain-A Journal of Neurology, 2019, 42 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain-A Journal of Neurology, Oxford University Press (OUP), 2019, 142 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain
Brain, Vol. 142, No 12 (2019) pp. 3806-3833
Van Steenwinckel, J, Schang, A-L, Krishnan, M L, Degos, V, Delahaye-Duriez, A, Bokobza, C, Csaba, Z, Verdonk, F, Montané, A, Sigaut, S, Hennebert, O, Lebon, S, Schwendimann, L, Le Charpentier, T, Hassan-Abdi, R, Ball, G, Aljabar, P, Saxena, A, Holloway, R K, Birchmeier, W, Baud, O, Rowitch, D, Miron, V, Chretien, F, Leconte, C, Besson, V C, Petretto, E G, Edwards, A D, Hagberg, H, Soussi-Yanicostas, N, Fleiss, B & Gressens, P 2019, ' Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain ', Brain, vol. 142, no. 12, pp. 3806–3833 . https://doi.org/10.1093/brain/awz319
Van Steenwinckel, J, Schang, A-L, Krishnan, M L, Degos, V, Delahaye-Duriez, A, Bokobza, C, Csaba, Z, Verdonk, F, Montané, A, Sigaut, S, Hennebert, O, Lebon, S, Schwendimann, L, Le Charpentier, T, Hassan-Abdi, R, Ball, G, Aljabar, P, Saxena, A, Holloway, R K, Birchmeier, W, Baud, O, Rowitch, D, Miron, V, Chretien, F, Leconte, C, Besson, V C, Petretto, E G, Edwards, A D, Hagberg, H, Soussi-Yanicostas, N, Fleiss, B & Gressens, P 2019, ' Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain ', Brain : a journal of neurology, vol. 142, no. 12, pp. 3806–3833 . https://doi.org/10.1093/brain/awz319
Brain-A Journal of Neurology, Oxford University Press (OUP), 2019, 42 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain-A Journal of Neurology, 2019, 42 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain-A Journal of Neurology, Oxford University Press (OUP), 2019, 142 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain
Brain, Vol. 142, No 12 (2019) pp. 3806-3833
Van Steenwinckel, J, Schang, A-L, Krishnan, M L, Degos, V, Delahaye-Duriez, A, Bokobza, C, Csaba, Z, Verdonk, F, Montané, A, Sigaut, S, Hennebert, O, Lebon, S, Schwendimann, L, Le Charpentier, T, Hassan-Abdi, R, Ball, G, Aljabar, P, Saxena, A, Holloway, R K, Birchmeier, W, Baud, O, Rowitch, D, Miron, V, Chretien, F, Leconte, C, Besson, V C, Petretto, E G, Edwards, A D, Hagberg, H, Soussi-Yanicostas, N, Fleiss, B & Gressens, P 2019, ' Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain ', Brain, vol. 142, no. 12, pp. 3806–3833 . https://doi.org/10.1093/brain/awz319
Van Steenwinckel, J, Schang, A-L, Krishnan, M L, Degos, V, Delahaye-Duriez, A, Bokobza, C, Csaba, Z, Verdonk, F, Montané, A, Sigaut, S, Hennebert, O, Lebon, S, Schwendimann, L, Le Charpentier, T, Hassan-Abdi, R, Ball, G, Aljabar, P, Saxena, A, Holloway, R K, Birchmeier, W, Baud, O, Rowitch, D, Miron, V, Chretien, F, Leconte, C, Besson, V C, Petretto, E G, Edwards, A D, Hagberg, H, Soussi-Yanicostas, N, Fleiss, B & Gressens, P 2019, ' Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain ', Brain : a journal of neurology, vol. 142, no. 12, pp. 3806–3833 . https://doi.org/10.1093/brain/awz319
International audience; Microglia of the developing brain have unique functional properties but how their activation states are regulated is poorly understood. Inflammatory activation of microglia in the still-developing brain of preterm-born infants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5010c4ea37526701c318b122a40130
https://www.repository.cam.ac.uk/handle/1810/301606
https://www.repository.cam.ac.uk/handle/1810/301606