Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Rebecca K Donegan"'
Autor:
Hadia Aftab, Rebecca K. Donegan
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Heme biosynthesis in the Gram-positive bacteria occurs mostly via a pathway that is distinct from that of eukaryotes and Gram-negative bacteria in the three terminal heme synthesis steps. In many of these bacteria heme is a necessary cofactor that fu
Externí odkaz:
https://doaj.org/article/ee766036931140ee88b59323d70f9c1b
Autor:
Rebecca K. Donegan, Yibo Fu, Jacqueline Copeland, Stanzin Idga, Gabriel Brown, Owen F. Hale, Avishek Mitra, Hui Yang, Harry A. Dailey, Michael Niederweis, Paras Jain, Amit R. Reddi
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially cytotoxic. Since M. tu
Externí odkaz:
https://doaj.org/article/7bf3e26261654a098f9c0eb2fdff1297
Autor:
Santi Mestre-Fos, Nicholas V. Hud, Anton S. Petrov, Raquel L. Lieberman, Bettina Bommarius, Kavita R. Matange, Loren Dean Williams, Anton V. Bryksin, Brett M. Barlow, Vinayak Agarwal, Gwendell Thomas, Robert G. Mannino, Pamela Pollet, Jennifer B. Glass, Chieri Ito, Emily G. Saccuzzo, Jessica C. Bowman, Mallory Hazell, Rebecca K. Donegan, Nguyet A. Nguyen, Samantha J. Mascuch, Suneesh C. Karunakaran, Hem R. Thapa, Gary P. Newnam, Andrés J. García, Brooke Rothschild-Mancinelli, Chiamaka T. Obianyor, Carolyn B. Ibberson, Sara Fakhretaha-Aval, Wilbur A. Lam, Liangjun Zhao, Minh Thu H. Ma, Rebecca Guth-Metzler, Julia Kubanek, Petar I. Penev
Publikováno v:
Journal of Biological Chemistry
Widespread testing for the presence of the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals remains vital for controlling the COVID-19 pandemic prior to the advent of an effective treatment. Challenges in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c475667bc2d71dfb929e97b52e3b2b8d
https://doi.org/10.1074/jbc.ra120.015434
https://doi.org/10.1074/jbc.ra120.015434
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130888 (2015)
Olfactomedin (OLF) domains are found within extracellular, multidomain proteins in numerous tissues of multicellular organisms. Even though these proteins have been implicated in human disorders ranging from cancers to attention deficit disorder to g
Externí odkaz:
https://doaj.org/article/23534b2e809d4d7193a166d9a0c9eaf0
Publikováno v:
Free Radical Biology and Medicine. 133:88-100
Heme is an essential cofactor and signaling molecule required for virtually all aerobic life. However, excess heme is cytotoxic. Therefore, heme must be safely transported and trafficked from the site of synthesis in the mitochondria or uptake at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091bdda794d77c83638d3470692e0f02
https://doi.org/10.1016/j.freeradbiomed.2018.08.005
https://doi.org/10.1016/j.freeradbiomed.2018.08.005
Autor:
Amit R. Reddi, Michael Niederweis, Hale Of, Harry A. Dailey, Copeland J, Hui Yang, Mitra A, Brown G, Rebecca K. Donegan, Paras Jain, Edgha S
Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis (Mtb). While heme is required for Mtb survival and virulence, it is also potentially cytotoxic. Since Mtb has the ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6553de51f92fe54c1cff2f4b0a9a06c3
https://doi.org/10.1101/2021.05.10.443464
https://doi.org/10.1101/2021.05.10.443464
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b27fbfee7c840eedc5e71e415f890680
https://doi.org/10.1016/j.jalz.2018.06.883
https://doi.org/10.1016/j.jalz.2018.06.883
Publikováno v:
Journal of Medicinal Chemistry. 59:788-809
Glaucoma, a heterogeneous ocular disorder affecting ∼60 million people worldwide, is characterized by painless neurodegeneration of retinal ganglion cells (RGCs), resulting in irreversible vision loss. Available therapies, which decrease the common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50c9dd75088ccfb5e8af2bd70b917c2b
https://doi.org/10.1021/acs.jmedchem.5b00828
https://doi.org/10.1021/acs.jmedchem.5b00828
Autor:
Elaine Nguyen, Shannon E. Hill, Raquel L. Lieberman, Katherine C. Turnage, Susan D. Orwig, Rebecca K. Donegan, Dana M. Freeman
Publikováno v:
Human Molecular Genetics. 24:2111-2124
Olfactomedin (OLF) domain-containing proteins play roles in fundamental cellular processes and have been implicated in disorders ranging from glaucoma, cancers and inflammatory bowel disorder, to attention deficit disorder and childhood obesity. We s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93456a0d94c24b8088d6a849b7f53e90
https://doi.org/10.1093/hmg/ddu730
https://doi.org/10.1093/hmg/ddu730
Publikováno v:
The Journal of biological chemistry. 293(29)
Glial immune activity is a key feature of Alzheimer's disease (AD). Given that the blood factors heme and hemoglobin (Hb) are both elevated in AD tissues and have immunomodulatory roles, here we sought to interrogate their roles in modulating β-amyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00224b99d6e0e49f3e9ac8a17b1030e5
https://pubmed.ncbi.nlm.nih.gov/29871926
https://pubmed.ncbi.nlm.nih.gov/29871926