Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Rebecca K Davis"'
Autor:
Alan P. Fields, Michael Leitges, Andras Khoor, Alyssa Kunz, Rebecca K. Davis, Roderick P. Regala
Supplementary Figure 1 from Atypical Protein Kinase Cι Is Required for Bronchioalveolar Stem Cell Expansion and Lung Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddb257c9431c396d8c5befe4211b44d
https://doi.org/10.1158/0008-5472.22383036
https://doi.org/10.1158/0008-5472.22383036
Autor:
Mark James Bamford, Andrew R. Calver, David Matthew Wilson, Rebecca K. Davis, Nicholas Bailey, Isabel Jm Beresford, Jason Witherington, Susannah Davis, Jon Graham Anthony Steadman, Phillip Jeffrey, Vicky Holland, Joanne Schogger, Christopher A. Parr, Jeffrey Wald, Teresa Heslop, Michael A. Briggs, Terrance A. Panchal, Leanne Harris, Andrew D. Medhurst, Kim Brackenborough, David Kenneth Dean, Tania O. Stean, Brenda K. Trail, Nigel Quashie, Angela Worby, Stephen J. Brough, Barry Crook, James Apps, Andrew K. Takle, Robert P. Davis, Sanjeet Singh Sehmi
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(24)
This Letter describes the discovery of GSK189254 and GSK239512 that were progressed as clinical candidates to explore the potential of H3 receptor antagonists as novel therapies for the treatment of Alzheimer's disease and other dementias. By careful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e541fa0f8606fd8aa20c773c236c2d64
https://pubmed.ncbi.nlm.nih.gov/24269482
https://pubmed.ncbi.nlm.nih.gov/24269482
Autor:
Alan P. Fields, Roderick P. Regala, Rebecca K. Davis, Alyssa Kunz, Andras Khoor, Michael Leitges
Protein kinase Cι (PKCι) is an oncogene required for maintenance of the transformed phenotype of non–small cell lung cancer cells. However, the role of PKCι in lung tumor development has not been investigated. To address this question, we establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b3768dd80765bf586a30c6b922165e
https://europepmc.org/articles/PMC2756303/
https://europepmc.org/articles/PMC2756303/
Autor:
Srikumar Chellappan, Rebecca K Davis
Publikováno v:
Drug newsperspectives. 21(6)
Cell-cycle progression in cancer is often mediated by disrupting the function of the retinoblastoma tumor suppressor protein, Rb. One way in which Rb's function is altered is through phosphorylation mediated by cyclin-dependent kinases (CDKs). Our st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492922b65aa8c73b8c43f4164846e5ae
https://pubmed.ncbi.nlm.nih.gov/18836591
https://pubmed.ncbi.nlm.nih.gov/18836591
Autor:
Ciaran M. Regan, Sandrine Ociepka, Rebecca K. Davis, Kim Brackenborough, Jane E. Cluderay, Alison M. Ray, Jeffrey Wald, Andrew D. Medhurst, M. Isabel Gonzalez, Michael A. Briggs, David Matthew Wilson, Jason Witherington, Isabel J. M. Beresford, Andrew G. Foley, Laurent Lacroix, Tania O. Stean, Joanne Schogger, Robert P. Davis, Andrew R. Calver, Graham Wadsworth, Angela Worby, Eric Southam, John B. Davis, Abbe Martyn, Neil Upton, Declan N.C. Jones, Jennifer C. Roberts, Jane Gartlon, Trevor White, Marie L. Woolley, Lee A. Dawson, Alan R. Atkins, Warren D. Hirst, Carol A. Jennings, Teresa Heslop, Brenda K. Trail, Barry Crook, Jackie Cilia
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 321(3)
6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) is a novel histamine H(3) receptor antagonist with high affinity for human (pK(i) = 9.59 -9.90) and rat (pK(i) = 8.51-9.17) H(3) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2455dc58b48aabeec4028425d545f9f
https://pubmed.ncbi.nlm.nih.gov/17327487
https://pubmed.ncbi.nlm.nih.gov/17327487
Autor:
Robert P. Davies, Teresa Heslop, Barry Crook, Rebecca K. Davis, M. Isabel Gonzalez, Andrew D. Medhurst, Tania O. Stean, Martin I. Smith, Jennifer C. Roberts, Sandrine Ociepka, Alison M. Ray, Trevor White, Kim Brackenborough, Michael A. Briggs, Andrew R. Calver, Jeffrey Wald, Ciaran M. Regan, Brenda K. Trail, Jason Witherington, Sharlin Ahmed, Joanne Schogger, David Virley, Andrew G. Foley, David Matthew Wilson, Graham Wadsworth
Publikováno v:
Alzheimer's & Dementia. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fe406a31c16360893b5546d83dba722
https://doi.org/10.1016/j.jalz.2006.05.223
https://doi.org/10.1016/j.jalz.2006.05.223