Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis

Autor: Rajiv Kumar, Patrick T. Bunn, Siddharth Sankar Singh, Susanna S. Ng, Marcela Montes de Oca, Fabian De Labastida Rivera, Shashi Bhushan Chauhan, Neetu Singh, Rebecca J. Faleiro, Chelsea L. Edwards, Teija C.M. Frame, Meru Sheel, Rebecca J. Austin, Steven W. Lane, Tobias Bald, Mark J. Smyth, Geoffrey.R. Hill, Shannon E. Best, Ashraful Haque, Dillon Corvino, Nic Waddell, Lambross Koufariotis, Pamela Mukhopadhay, Madhukar Rai, Jaya Chakravarty, Om Prakash Singh, David Sacks, Susanne Nylen, Jude Uzonna, Shyam Sundar, Christian R. Engwerda

Publikováno v: Cell Reports, Vol 30, Iss 8, Pp 2512-2525.e9 (2020)

Summary: Type I interferons (IFNs) play critical roles in anti-viral and anti-tumor immunity. However, they also suppress protective immune responses in some infectious diseases. Here, we identify type I IFNs as major upstream regulators of CD4+ T ce

Externí odkaz: https://doaj.org/article/e785a439bde64e73885e903f52fe0682

Galectin-1 Impairs the Generation of Anti-Parasitic Th1 Cell Responses in the Liver during Experimental Visceral Leishmaniasis

Autor: Patrick T. Bunn, Marcela Montes de Oca, Fabian de Labastida Rivera, Rajiv Kumar, Chelsea L. Edwards, Rebecca J. Faleiro, Susanna S. Ng, Meru Sheel, Yulin Wang, Fiona H. Amante, Ashraful Haque, Christian R. Engwerda

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Many infectious diseases are characterized by the development of immunoregulatory pathways that contribute to pathogen persistence and associated disease symptoms. In diseases caused by intracellular parasites, such as visceral leishmaniasis (VL), va

Externí odkaz: https://doaj.org/article/90b714a06a994e9780cda45e80e88b05

Immune regulation during chronic visceral leishmaniasis.

Autor: Rebecca J Faleiro, Rajiv Kumar, Louise M Hafner, Christian R Engwerda

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e2914 (2014)

Visceral leishmaniasis is a chronic parasitic disease associated with severe immune dysfunction. Treatment options are limited to relatively toxic drugs, and there is no vaccine for humans available. Hence, there is an urgent need to better understan

Externí odkaz: https://doaj.org/article/0d5dc2a5687544f6ba10ae24288b0cfa

Crohn's disease is facilitated by a disturbance of programmed death‐1 ligand 2 on blood dendritic cells

Autor: Tam H. Nguyen, Michelle N. Wykes, Rebecca J. Faleiro, Graham L. Radford-Smith, Clay Winterford, Ji Liu, Deshapriya S. Karunarathne, Aleksandra Edmundson, Lisa A. Simms

Publikováno v: Clinical & Translational Immunology
Clinical & Translational Immunology, Vol 8, Iss 7, Pp n/a-n/a (2019)

Objective Crohn's disease (CD) is characterised by inflammation, predominantly associated with ilea. To investigate the basis for this inflammation in patients with CD, we examined dendritic cells (DC) which are pivotal for maintenance of immunologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f22881912e629f9ab34ab5dbdcc7657
http://europepmc.org/articles/PMC6657371

Distinct Roles for CD4+ Foxp3+ Regulatory T Cells and IL-10-Mediated Immunoregulatory Mechanisms during Experimental Visceral Leishmaniasis Caused by Leishmania donovani

Autor: Jude E. Uzonna, Rebecca J. Faleiro, Christian R. Engwerda, Susanna S. Ng, Meru Sheel, Ashraful Haque, Fiona H. Amante, Chelsea L. Edwards, Teija C. M. Frame, Rajesh Kumar, Fabian de Labastida Rivera, Patrick T. Bunn, Marcela Montes de Oca, Geoffrey R. Hill, Werner Müller

Publikováno v: Bunn, P T, Montes de Oca, M, de Labastida Rivera, F, Kumar, R, Ng, S S, Edwards, C L, Faleiro, R J, Sheel, M, Amante, F H, Frame, T C M, Muller, W, Haque, A, Uzonna, J E, Hill, G R & Engwerda, C R 2018, ' Distinct Roles for CD4+ Foxp3+ Regulatory T Cells and IL-10-Mediated Immunoregulatory Mechanisms during Experimental Visceral Leishmaniasis Caused by Leishmania donovani ', Journal of immunology (Baltimore, Md. : 1950), vol. 201, no. 11, pp. 3362-3372 . https://doi.org/10.4049/jimmunol.1701582

The outcome of intracellular parasitic infection can be determined by the immunoregulatory activities of natural regulatory CD4+ Foxp3+ T (Treg) cells and the anti-inflammatory cytokine IL-10. These mechanisms protect tissue but can also suppress ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae0e20e5f3abe9271e7fc7ffc2c06c0
https://www.research.manchester.ac.uk/portal/en/publications/distinct-roles-for-cd4-foxp3-regulatory-t-cells-and-il10mediated-immunoregulatory-mechanisms-during-experimental-visceral-leishmaniasis-caused-by-leishmania-donovani(8da45e8d-adc6-46f1-bda1-1fc1a60f3507).html