Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rebecca J. Carter"'
Publikováno v:
Movement Disorders. 15:925-937
Mice transgenic for the first exon of the human Huntington's disease (HD) gene carrying an expanded CAG repeat expansion (R6/2 line) develop a progressive neurologic phenotype with symptoms resembling those seen in HD. The overt symptoms of R6/2 mice
Autor:
Amarbirpal Mahal, Stephen B. Dunnett, Laura Mangiarini, Lisa Lione, A. Jennifer Morton, Kerry P.S.J. Murphy, Gillian P. Bates, Rebecca J. Carter
Publikováno v:
The Journal of Neuroscience. 20:5115-5123
Huntington's disease (HD) is an autosomal dominant progressive and fatal neurodegenerative brain disorder caused by an expanded CAG/polyglutamine repeat in the coding region of the gene. Presymptomatic Huntington's disease patients often exhibit cogn
Publikováno v:
The Journal of Neuroscience. 19:10428-10437
Cognitive decline is apparent in the early stages of Huntington's disease and progressively worsens throughout the course of the disease. Expression of the human Huntington's disease mutation in mice (R6/2 line) causes a progressive neurological phen
Autor:
A. J. Morton, Gillian P. Bates, Eduardo Miguel Torres, L. Mangiarini, Stephen B. Dunnett, Colin Watts, Rebecca J. Carter, A. Mahal
Publikováno v:
Experimental Neurology. 154:31-40
Striatal grafts have been proposed as a potential strategy for striatal repair in Huntington's disease, but it is unknown whether the diseased brain will compromise graft survival. A transgenic mouse line has recently been described in which hemizygo
Publikováno v:
Current Protocols in Neuroscience
Measurement of motor coordination and balance can be used not only to assess the effect of drugs or other experimental manipulations on mice and rats, but also to characterize the motor phenotype of transgenic or knock-out animals. Three well establi
Publikováno v:
Brain research. 966(2)
The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. The RAGE–ligand interaction has a putative role in a range of chronic disorders and is also known to contr
Autor:
Trevor Humby, Laura Mangiarini, Rebecca J. Carter, Stephen B. Dunnett, A.J. Morton, Gillian P. Bates, Lisa Lione, Amarbirpal Mahal
Transgenic mice expressing exon 1 of the human Huntington’s disease (HD) gene carrying a 141–157 CAG repeat (line R6/2) develop a progressive neurological phenotype with motor symptoms resembling those seen in HD. We have characterized the motor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b7fe7b7bcf4b670d34db8fcff1f819
https://europepmc.org/articles/PMC6782264/
https://europepmc.org/articles/PMC6782264/
Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by chorea, psychiatric disturbances, and dementia. The striatum is the primary site of neuronal loss in HD; however, neither the mechanism of neurodegeneration nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105b003696a5b23ad1d526b58014c489
https://europepmc.org/articles/PMC6793275/
https://europepmc.org/articles/PMC6793275/