Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Rebecca J Howard"'
Autor:
Johanna KS Tiemann, Magdalena Szczuka, Lisa Bouarroudj, Mohamed Oussaren, Steven Garcia, Rebecca J Howard, Lucie Delemotte, Erik Lindahl, Marc Baaden, Kresten Lindorff-Larsen, Matthieu Chavent, Pierre Poulain
Publikováno v:
eLife, Vol 12 (2024)
The rise of open science and the absence of a global dedicated data repository for molecular dynamics (MD) simulations has led to the accumulation of MD files in generalist data repositories, constituting the dark matter of MD — data that is techni
Externí odkaz:
https://doaj.org/article/c3061f03d4e2413684cd2f2b1b6d8754
Autor:
Michael J Osland, Kereen T Griffith, Jack C Larriviere, Laura C Feher, Donald R Cahoon, Nicholas M Enwright, David A Oster, John M Tirpak, Mark S Woodrey, Renee C Collini, Joseph J Baustian, Joshua L Breithaupt, Julia A Cherry, Jeremy R Conrad, Nicole Cormier, Carlos A Coronado-Molina, Joseph F Donoghue, Sean A Graham, Jennifer W Harper, Mark W Hester, Rebecca J Howard, Ken W Krauss, Daniel E Kroes, Robert R Lane, Karen L McKee, Irving A Mendelssohn, Beth A Middleton, Jena A Moon, Sarai C Piazza, Nicole M Rankin, Fred H Sklar, Greg D Steyer, Kathleen M Swanson, Christopher M Swarzenski, William C Vervaeke, Jonathan M Willis, K Van Wilson
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0183431 (2017)
Coastal wetland responses to sea-level rise are greatly influenced by biogeomorphic processes that affect wetland surface elevation. Small changes in elevation relative to sea level can lead to comparatively large changes in ecosystem structure, func
Externí odkaz:
https://doaj.org/article/4b1a5ec59887401b9e61bb62baec6f1c
Autor:
Samuel Murail, Rebecca J Howard, Torben Broemstrup, Edward J Bertaccini, R Adron Harris, James R Trudell, Erik Lindahl
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 10, p e1002710 (2012)
Cys-loop receptors constitute a superfamily of pentameric ligand-gated ion channels (pLGICs), including receptors for acetylcholine, serotonin, glycine and γ-aminobutyric acid. Several bacterial homologues have been identified that are excellent mod
Externí odkaz:
https://doaj.org/article/d08ef181a855484ab0859f2c6b752cde
Autor:
Dagimhiwat H. Legesse, Chen Fan, Jinfeng Teng, Yuxuan Zhuang, Rebecca J. Howard, Colleen M. Noviello, Erik Lindahl, Ryan E. Hibbs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract γ-Aminobutyric acid type A (GABAA) receptors mediate fast inhibitory signaling in the brain and are targets of numerous drugs and endogenous neurosteroids. A subset of neurosteroids are GABAA receptor positive allosteric modulators; one of
Externí odkaz:
https://doaj.org/article/9c3fd95d1605447bb8e398d6acc64164
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
GABAA receptors are important targets for anxiety, sedation and anesthesia. Here, the authors present structures bound by zolpidem (Ambien), the most prescribed hypnotic in the US, and DMCM, a negative modulator, providing insights into receptor modu
Externí odkaz:
https://doaj.org/article/8bdf68ac057b4f82838f0620509d6a37
Autor:
Vasyl Bondarenko, Qiang Chen, Kevin Singewald, Nandan Haloi, Tommy S. Tillman, Rebecca J. Howard, Erik Lindahl, Yan Xu, Pei Tang
Publikováno v:
ACS Chemical Neuroscience. 14:1156-1165
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fca4039d8e195ef31f5986ba60afb0ca
https://doi.org/10.1021/acschemneuro.2c00783
https://doi.org/10.1021/acschemneuro.2c00783
Autor:
Nandan Haloi, Shan Huang, Aaron N. Nichols, Eve J. Fine, Christopher B. Marotta, Dennis A. Dougherty, Erik Lindahl, Rebecca J. Howard, Stephen L. Mayo, Henry A. Lester
Publikováno v:
bioRxiv
To develop more sensitive fluorescent protein sensors for nicotine, we combined computational protein design, site-saturated, site-directed, and combinatorial mutagenesis with fluorescence assays, molecular dynamics simulations, and absorbance measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e006d2d998b11ecd045bc5d0daafcc24
https://doi.org/10.1101/2023.01.16.524298
https://doi.org/10.1101/2023.01.16.524298
Autor:
Laura C. Feher, Michael J. Osland, Karen L. McKee, Kevin R. T. Whelan, Carlos Coronado-Molina, Fred H. Sklar, Ken W. Krauss, Rebecca J. Howard, Donald R. Cahoon, James C. Lynch, Lukas Lamb-Wotton, Tiffany G. Troxler, Jeremy R. Conrad, Gordon H. Anderson, William C. Vervaeke, Thomas J. Smith III, Nicole Cormier, Andrew S. From, Larry Allain
Publikováno v:
Estuaries and Coasts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7407dfbbc57899d5ed3ad5aa2158a710
https://doi.org/10.1007/s12237-022-01141-2
https://doi.org/10.1007/s12237-022-01141-2
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Molecular dynamics simulations of the alpha-7 nicotinic receptor, both atomistic (ion permeation free energy calculation) and coarse-grained (lipid and drug binding).
Two amino residues were incorrectly assigned in the original PDB file. N35 sho
Two amino residues were incorrectly assigned in the original PDB file. N35 sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e780d5f32423b671cadb81670b64b4df
https://doi.org/10.1073/pnas.2208081119
https://doi.org/10.1073/pnas.2208081119
Ligand-gated ion channels transduce electrochemical signals in neurons and other excitable cells. Aside from canonical ligands, phospholipids are thought to bind specifically to the transmembrane domain of several ion channels. However, structural de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce49f813e4dace3e999da40c16359305