Zobrazeno 1 - 10
of 391
pro vyhledávání: '"Rebecca J Dearman"'
Publikováno v:
Journal of Immunotoxicology, Vol 19, Iss 1, Pp 1-7 (2022)
Biotherapeutic monoclonal antibodies (mAb) play important roles in clinical medicine but their potential to elicit immune responses in patients remains a major issue. In a study designed to investigate the effect of aggregation on immunogenic respons
Externí odkaz:
https://doaj.org/article/16b939625b724fcaace297b900668148
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106955 (2014)
The aryl hydrocarbon receptor (AhR) has been shown to be required for optimal Thelper (Th) 17 cell activation. Th17 cells provide immunity against extracellular pathogens and are implicated in autoimmune diseases. Herein, the role of the AhR in cytok
Externí odkaz:
https://doaj.org/article/d1d3a763c68e4fe2926ec15da99b4192
Publikováno v:
International Journal of Immunogenetics. 48:145-156
Granulocytes are an essential part of both the innate and adaptive immune systems. Human neutrophil antigens (HNAs) are a family of epitopes that are located on glycoproteins that are mostly expressed on human granulocytes. Antibodies that recognize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9368eb3f06755c92c69b3d76456ea9f6
https://doi.org/10.1111/iji.12514
https://doi.org/10.1111/iji.12514
Autor:
J Osborne, A Luvai, Andrew M. Day, Katharine Hayden, J West, Deepa Narayanan, Nuthar Jassam, N El-Farhan, Julian H. Barth, Rebecca J. Dearman, S Zouwail, D Turnock, S Willett, Graham R. Lee, Jinny Jeffery, K Earp
Publikováno v:
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 57:373-381
BackgroundHarmonization of reference intervals for analytes that have a sound calibration and metrological traceability is a widely recommended practice. The UK Pathology Harmony has recently harmonized reference intervals for calcium and albumin. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a80eccd5a31fb281e24864d7a1371fc
https://doi.org/10.1177/0004563220944204
https://doi.org/10.1177/0004563220944204
Publikováno v:
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 57:316-324
Background Calcium circulates bound to albumin and changes in albumin concentration will therefore affect total calcium measurements. In order to mitigate this, correction factors are frequently used. The most widely used correction equation was desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59c1a892b2f6df5ddc60a4f103ae91ae
https://doi.org/10.1177/0004563220926542
https://doi.org/10.1177/0004563220926542
Autor:
Shalom A. Gurjar, Jun X. Wheeler, Jeremy P. Derrick, Ian Kimber, Rebecca J. Dearman, Robin Thorpe, Meenu Wadhwa, Clive Metcalfe
Publikováno v:
The Journal of Biological Chemistry
Gurjar, S A, Wheeler, J X, Wadwha, M, Thorpe, R, Kimber, I, Derrick, J, Dearman, R & Metcalfe, C 2019, ' The impact of thioredoxin reduction of allosteric disulfide bonds on the therapeutic potential of monoclonal antibodies ', Journal of Biological Chemistry, vol. 294, no. 51, pp. 19616-19634 . https://doi.org/10.1074/jbc.RA119.010637
Gurjar, S A, Wheeler, J X, Wadwha, M, Thorpe, R, Kimber, I, Derrick, J, Dearman, R & Metcalfe, C 2019, ' The impact of thioredoxin reduction of allosteric disulfide bonds on the therapeutic potential of monoclonal antibodies ', Journal of Biological Chemistry, vol. 294, no. 51, pp. 19616-19634 . https://doi.org/10.1074/jbc.RA119.010637
Therapeutic monoclonal antibodies (mAbs) are used to manage a wide range of cancers and autoimmune disorders. However, mAb-based treatments are not always successful, highlighting the need for a better understanding of the factors influencing mAb eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1fab4d05c54626e7cc50474a4fe50d
http://europepmc.org/articles/PMC6926469
http://europepmc.org/articles/PMC6926469
Autor:
John Paul Gosling, Amy Popple, Ian Kimber, Jason Williams, Clare Stretton, Rebecca J. Dearman, Kate Wicks, Gavin Maxwell, Lorna Beresford
Publikováno v:
Wicks, K, Stretton, C, Popple, A, Beresford, L, Williams, J, Maxwell, G, Gosling, J P, Kimber, I & Dearman, R J 2019, ' T lymphocyte phenotype of contact allergic patients : experience with nickel and p-phenylenediamine ', Contact dermatitis . https://doi.org/10.1111/cod.13246
BACKGROUND: There is considerable interest in understanding the immunological variables that have the greatest influence on the effectiveness of sensitization by contact allergens, particularly in the context of developing new paradigms for risk asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07003731c85c9a6d34db194ee0f4f63d
https://doi.org/10.1111/cod.13246
https://doi.org/10.1111/cod.13246
Autor:
Ian Kimber, Jason M. Winget, Sebastian Maurer-Stroh, Cindy A. Ryan, Rebecca J. Dearman, Rohan Lalith Wimalasena, G. Frank Gerberick, Nora L Krutz
Publikováno v:
Toxicological Sciences. 170:210-222
Use of botanicals and natural substances in consumer products has increased in recent years. Such extracts can contain protein that may theoretically represent a potential risk of IgE-mediated allergy. No method has yet been generally accepted or val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4864c5eee53391b6511a1a80af08942
https://doi.org/10.1093/toxsci/kfz078
https://doi.org/10.1093/toxsci/kfz078
Publikováno v:
Annals of clinical biochemistry. 57(5)
AimThe generation of accurate, comparable results from traceable measurement procedures is a primary goal in harmonization efforts. In this study, the analytical performance of routine methods for calcium and albumin measurement is assessed to define
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac917b74783b149ed41ca758c889811
https://pubmed.ncbi.nlm.nih.gov/32646227
https://pubmed.ncbi.nlm.nih.gov/32646227