Výsledky vyhledávání - "Rebecca J Chapman"

Akademický článek

Multi-omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high-risk pediatric ependymoma

Autor: Andrea M. Griesinger, Kent Riemondy, Nithyashri Eswaran, Andrew M. Donson, Nicholas Willard, Eric W. Prince, Simon M.L. Paine, Georgia Bowes, John Rheaume, Rebecca J. Chapman, Judith Ramage, Andrew Jackson, Richard G. Grundy, Nicholas K. Foreman, Timothy A. Ritzmann

Publikováno v: iScience, Vol 26, Iss 9, Pp 107585- (2023)

Summary: Ependymoma (EPN) is a devastating childhood brain tumor. Single-cell analyses have illustrated the cellular heterogeneity of EPN tumors, identifying multiple neoplastic cell states including a mesenchymal-differentiated subpopulation which c

Externí odkaz: https://doaj.org/article/c21cc25b1c034ef5b5f324e282f7169c

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Supplementary Table 4 from PI3K Pathway Activation Provides a Novel Therapeutic Target for Pediatric Ependymoma and Is an Independent Marker of Progression-Free Survival

Autor: Richard G. Grundy, Beth Coyle, John-Paul Kilday, Rebecca J. Chapman, Cerys Mayne, Hazel A. Rogers

PDF file - 31K, Summary of univariate survival statistics for factors analyzed, for an association with progression free survival, across the ependymoma cohort. A Kaplan Meier with a log rank test was used. Only factors with a p value less than 0.25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5741196525da7dcac8c2740dba8a55ab
https://doi.org/10.1158/1078-0432.22448552

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Supplementary Table 2 from PI3K Pathway Activation Provides a Novel Therapeutic Target for Pediatric Ependymoma and Is an Independent Marker of Progression-Free Survival

Autor: Richard G. Grundy, Beth Coyle, John-Paul Kilday, Rebecca J. Chapman, Cerys Mayne, Hazel A. Rogers

PDF file - 35K, The table lists genes from the PI3K pathway displaying a significant difference in mRNA expression between tumors from different locations, identified using an ANOVA test. mRNA data originally published by Johnson et al. 2010 (Geo acc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a9f0f6202985e4fe39092447391926
https://doi.org/10.1158/1078-0432.22448558.v1

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Supplementary Table 1 from PI3K Pathway Activation Provides a Novel Therapeutic Target for Pediatric Ependymoma and Is an Independent Marker of Progression-Free Survival

Autor: Richard G. Grundy, Beth Coyle, John-Paul Kilday, Rebecca J. Chapman, Cerys Mayne, Hazel A. Rogers

PDF file - 1016K, The table lists genes displaying a significant difference in mRNA expression between tumors from different locations, identified using an ANOVA test. mRNA data originally published by Johnson et al. 2010 (Geo accession number GSE216

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b154b7288893b209784f34eb2003104
https://doi.org/10.1158/1078-0432.22448561.v1

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Supplementary Figure 1 from PI3K Pathway Activation Provides a Novel Therapeutic Target for Pediatric Ependymoma and Is an Independent Marker of Progression-Free Survival

Autor: Richard G. Grundy, Beth Coyle, John-Paul Kilday, Rebecca J. Chapman, Cerys Mayne, Hazel A. Rogers

PDF file - 163K, Survival analysis of P-AKT in tumors from patients in two clinical trial cohorts, CNS9204 and CNS9904,using the Kaplan Meier method with a log rank test. For the CNS9204 trial a significant association was found between P-AKT-N posit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b384aff1c54a5d8d10d7d7ce421cb1a
https://doi.org/10.1158/1078-0432.22448564

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Data from PI3K Pathway Activation Provides a Novel Therapeutic Target for Pediatric Ependymoma and Is an Independent Marker of Progression-Free Survival

Autor: Richard G. Grundy, Beth Coyle, John-Paul Kilday, Rebecca J. Chapman, Cerys Mayne, Hazel A. Rogers

Purpose: Currently, there are few effective adjuvant therapies for pediatric ependymoma outside confocal radiation, and prognosis remains poor. The phosphoinositide 3-kinase (PI3K) pathway is one of the most commonly activated pathways in cancer. PI3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d42d6c4ac3aa214b2f0a2ae7686fd52
https://doi.org/10.1158/1078-0432.c.6521426.v1

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SIOP Ependymoma I: Final results, long-term follow-up, and molecular analysis of the trial cohort—A BIOMECA Consortium Study

Autor: Timothy A Ritzmann, Rebecca J Chapman, John-Paul Kilday, Nicola Thorp, Piergiorgio Modena, Robert A Dineen, Donald Macarthur, Conor Mallucci, Timothy Jaspan, Kristian W Pajtler, Marzia Giagnacovo, Thomas S Jacques, Simon M L Paine, David W Ellison, Eric Bouffet, Richard G Grundy

Publikováno v: Neuro Oncol

Background SIOP Ependymoma I was a non-randomised trial assessing event free and overall survival (EFS/OS) of non-metastatic intracranial ependymoma in children aged 3–21 years treated with a staged management strategy. A further aim was to assess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ea4d0e85dbb3c7fae100da09620ade
https://doi.org/10.1093/neuonc/noac012

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Network-based activity induced by 4-aminopyridine in rat dorsal hornin vitrois mediated by both chemical and electrical synapses

Autor: Anne King, Paul F. Cilia La Corte, Rebecca J. Chapman, Aziz Asghar

Publikováno v: The Journal of Physiology. 587:2499-2510

This study investigated the role of electrical and chemical synapses in sustaining 4-aminopyridine (4-AP)-evoked network activity recorded extracellularly from substantia gelatinosa (SG) of young rat spinal cord in vitro. Superfusion of 4-AP (50 μm)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a25db24ad1439fd39e5a0333bad0bab
https://doi.org/10.1113/jphysiol.2009.171777

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