Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rebecca Hagan"'
Autor:
Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael P. Maher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the nervous system. ASIC gating is modulated by divalent cations as well as small molecules; however, the molecular determinants of gating modulation by d
Externí odkaz:
https://doaj.org/article/7532453b22314d01ada9b275f434a0b8
Autor:
Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, David Lin, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael Maher
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Liu et al study the molecular and structural mechanism of the modulation of ASIC1 channel gating using functional, crystallographic, computational and mutational approaches. They identify small molecules that allosterically stabilize the closed state
Externí odkaz:
https://doaj.org/article/cd6928ca293c4d9a8cd20517994d727a
Autor:
Rebecca Hagan, Elizabeth Rex, David Woody, Monika Milewski, Thomas Glaza, Michael P. Maher, Yi Liu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract L-type calcium channels (LTCCs) are highly expressed in the heart and brain and are critical for cardiac and neuronal functions. LTCC-blocking drugs have a long and successful record in the clinic for treating cardiovascular disorders. In co
Externí odkaz:
https://doaj.org/article/d47221df885344dc960f53333798321c
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Acid-Sensing Ion Channels (ASICs) are gated by extracellular protons and play important roles in physiological and pathological states, such as pain and stroke. ASIC1a and ASIC2a, two of the most highly expressed subunits in the brain, form
Externí odkaz:
https://doaj.org/article/6ecfee660a634987bfb6e194583a7b0a
Autor:
Jason C. Rech, Bruce L. Grasberger, Michael A. Letavic, Jinquan Luo, Changlu Liu, Jichun Ma, Michael P. Maher, Renee L. DesJarlais, Jeffrey Schoellerman, Rebecca Hagan, Yi Liu, Robyn L. Miller, David Lin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology
Communications Biology
Acid-sensing ion channels (ASICs) are proton-gated cation channels critical for neuronal functions. Studies of ASIC1, a major ASIC isoform and proton sensor, have identified acidic pocket, an extracellular region enriched in acidic residues, as a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcb9a64556aa30386ccae13fe0c1e06
https://doaj.org/article/cd6928ca293c4d9a8cd20517994d727a
https://doaj.org/article/cd6928ca293c4d9a8cd20517994d727a
Autor:
Monika Milewski, Michael P. Maher, Thomas Glaza, Elizabeth B. Rex, David Woody, Yi Liu, Rebecca Hagan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
L-type calcium channels (LTCCs) are highly expressed in the heart and brain and are critical for cardiac and neuronal functions. LTCC-blocking drugs have a long and successful record in the clinic for treating cardiovascular disorders. In contrast, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d4af779c03c8c756461918a2bb4abf
https://doi.org/10.1038/s41598-020-80692-5
https://doi.org/10.1038/s41598-020-80692-5
Autor:
John Park, Abhi Solanki, Rebecca Hagan, Lindsay Puckett, William C. Sleeman, Christina Chapman, Evangelia Katsoulakis, Michael P. Hagan, Jatinder Palta, Rishabh Kapoor
Publikováno v:
Archives of Cancer Biology and Therapy. 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adbad3c7668dcc20f2ddc8fc73d30994
https://doi.org/10.33696/cancerbiology.1.006
https://doi.org/10.33696/cancerbiology.1.006
Autor:
Q. Xu, Tony L. Yaksh, William A. Eckert, Michael J. Hunter, Rebecca Hagan, J. Freedman, M. Zhou, A. D. Piekarz, Ross Fellows, Rachelle Bonesteel, Kelly A. Eddinger, Michael W. Pennington, Alan Gibbs, Yanfang Liu, Alan D. Wickenden, Ronald V. Swanson, Robert A. Neff, Mack Flinspach
Publikováno v:
Scientific Reports
Scientific reports, vol 7, iss 1
Scientific reports, vol 7, iss 1
Pain places a devastating burden on patients and society and current pain therapeutics exhibit limitations in efficacy, unwanted side effects and the potential for drug abuse and diversion. Although genetic evidence has clearly demonstrated that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d007efa4fb9267ccd4fec38368d0f7cc
https://doi.org/10.1038/srep39662
https://doi.org/10.1038/srep39662
Autor:
Grzegorz Bulaj, Pradip K. Bandyopadhyay, Yi Liu, Shrinivasan Raghuraman, Baldomero M. Olivera, Layla Azam, Natali A. Minassian, Marshall Bern, Beatrix Ueberheide, Rebecca Hagan, H. Mimi Zhou, Brad R. Green, Julita S. Imperial, Doju Yoshikami, Alan D. Wickenden, Aleksandra Walewska, Joanna Gajewiak, Min Min Zhang, Mack Flinspach
Publikováno v:
Proceedings of the National Academy of Sciences. 111:2758-2763
A cone snail venom peptide, μO§-conotoxin GVIIJ from Conus geographus, has a unique posttranslational modification, S-cysteinylated cysteine, which makes possible formation of a covalent tether of peptide to its target Na channels at a distinct lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16aa93a382b2f4eabc990179cc3ecc5
https://doi.org/10.1073/pnas.1324189111
https://doi.org/10.1073/pnas.1324189111
Autor:
Rebecca Hagan Lee
A thoroughly English girl raised in Hong Kong, Julie Jane Parham has spent her entire life walking the line between two worlds. When her closest friend, Su Mi, becomes the victim of an arranged marriage gone horribly wrong, Julie travels to San Franc
