Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Rebecca H. Pouwer"'
Autor:
Ian D. Jenkins, Rebecca H. Pouwer, Ronald J. Quinn, Mariyam Murtaza, Fatemeh Mazraati Tajabadi, Miaomiao Liu, Yousef Dashti, Marc Ronald Campitelli, Stephen A. Wood, George D. Mellick
Publikováno v:
Journal of medicinal chemistry. 61(15)
A chemoinformatic method was developed to extract nonflat scaffolds embedded in natural products within the Dictionary of Natural Products (DNP). The cedrane scaffold was then chosen as an example of a nonflat scaffold that directs substituents in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9d421b0c005547b6bb11d2aad52b79
https://pubmed.ncbi.nlm.nih.gov/30005573
https://pubmed.ncbi.nlm.nih.gov/30005573
Publikováno v:
Journal of Natural Products. 78:1215-1220
(1)H NMR fingerprints were used as the guiding principle for the isolation of minor compounds related to the l-type amino acid transporter inhibitors venulosides A (1) and B (2). Two new monoterpene glycosides, namely, venulosides C (3) and D (4), we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2704061e927ecd436f04b1d98501810c
https://doi.org/10.1021/np500968t
https://doi.org/10.1021/np500968t
Autor:
Michael D. Edstein, Peter Conrad Healy, Anna Campbell, Scott Blundell, Tina S. Skinner-Adams, Rohan A. Davis, Ronald J. Quinn, Brett D. Schwartz, Rebecca H. Pouwer, Karren D. Beattie, Maria Koltun, Donna Mackenzie, Katherine T. Andrews, Susan A. Charman, Mark J. Coster
Publikováno v:
Organic & Biomolecular Chemistry. 13:1558-1570
A series of amide (8–32, 40–45) and urea (33, 34, 36–39) analogues based on the thiaplakortone A natural product scaffold were synthesised and screened for in vitro antimalarial activity against chloroquine-sensitive (3D7) and chloroquine- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4940de954a482ddabbd15add60bf330
https://doi.org/10.1039/c4ob01849d
https://doi.org/10.1039/c4ob01849d
Publikováno v:
Angewandte Chemie. 126:13882-13906
Vor uber hundert Jahren begann Professor Julius Bredt seine Forschungskarriere auf dem Gebiet der verbruckten bicyclischen Systeme, die durch ein Bruckenkopf-Alken unter Ringspannung stehen. Seine kritischen Betrachtungen mundeten in der Formulierung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afe9298564cb524a38e343bc22936a97
https://doi.org/10.1002/ange.201400932
https://doi.org/10.1002/ange.201400932
Autor:
Rebecca H. Pouwer, John E.J. Rasko, Charles G. Bailey, Renae M. Ryan, Ronald J. Quinn, Josep Font, Anne M. Moran, Sarah Ann Bonham, Jeff Holst, Tanja Grkovic, Mika Jormakka, Qian Wang
Publikováno v:
ACS Chemical Biology
The L-type amino acid transporter (LAT) family consists of four members (LAT1-4) that mediate uptake of neutral amino acids including leucine. Leucine is not only important as a building block for proteins, but plays a critical role in mTORC1 signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6332fcf7f823c893444f634e397e6ac5
https://doi.org/10.1021/cb500120x
https://doi.org/10.1021/cb500120x
Autor:
Alba Noel, Tanja Grkovic, John N. A. Hooper, Rebecca H. Pouwer, Stephen A. Wood, Luca Gambini, George D. Mellick, Marie-Laure Vial, Ronald J. Quinn
Publikováno v:
Angewandte Chemie (International Ed. in English)
The NMR spectrum of a mixture of small molecules is a fingerprint of all of its components. Herein, we present an NMR fingerprint method that takes advantage of the fact that fractions contain simplified NMR profiles, with minimal signal overlap, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6292241f8bd1090e2f74e2733eab46
https://doi.org/10.1002/anie.201402239
https://doi.org/10.1002/anie.201402239
Autor:
Craig M. Williams, Rebecca H. Pouwer
Publikováno v:
Synlett. 23:1446-1458
A review surveying the synthetic methodology developed by the Williams group over the last ten years, driven by natural product total synthesis, is presented. An underlying theme over this time has been the reliance on physical organic chemistry, org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::285f97c07d5fef1e458079d0c3b00e90
https://doi.org/10.1055/s-0031-1290967
https://doi.org/10.1055/s-0031-1290967
Publikováno v:
Angewandte Chemie International Edition. 51:4536-4561
With their fascinating biological profiles and stunningly complex molecular architectures, the polycyclic polyprenylated acylphloroglucinols (PPAPs) have long provided a fertile playing field for synthetic organic chemists. In particular, the recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f0cc3fc615506373ece2f7cac07673
https://doi.org/10.1002/anie.201103873
https://doi.org/10.1002/anie.201103873
Publikováno v:
Angewandte Chemie. 124:4612-4638
Mit ihren faszinierenden biologischen Profilen und erstaunlich komplexen Architekturen waren die polycyclischen polyprenylierten Acylphloroglucine (PPAPs) seit langem ein ertragreiches Gebiet fur Organiker. Besonders das jungste Aufkommen innovativer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e474c9805f8d0b5844b65e2bae5fec5
https://doi.org/10.1002/ange.201103873
https://doi.org/10.1002/ange.201103873
Publikováno v:
European Journal of Organic Chemistry. 2012:1633-1638
The 19-nor-clerodanes are compact, densely functionalized diterpenes based on a stereocentre-rich decalin scaffold. To date only a few examples of the 19-nor-clerodanes have been synthesized, hence new flexible strategies are required. We herein desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fad83c313cb68e8573bb153fe0915a6
https://doi.org/10.1002/ejoc.201101807
https://doi.org/10.1002/ejoc.201101807