Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rebecca G. Lawlor"'
Autor:
Anushka eDongre, Lalitha eSurampudi, Rebecca G Lawlor, Abdul H Fauq, Lucio eMiele, Todd E Golde, Lisa M Minter, Barbara A Osborne
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-JΚ, resulting in the activation of downstream target genes. This canonical Not
Externí odkaz:
https://doaj.org/article/dd8f3770d026479d94bee87c73e1bc7d
Autor:
Shelly R. Peyton, Constance C Angelou, Rebecca G. Lawlor, Elizabeth Iverson, Lisa M. Minter, Leonid A. Pobezinsky, Jyothi Vijayaraghavan, Carey E. Dougan, Barbara A. Osborne, Vanja Lazarevic, Motoko Y. Kimura, Alexandria C Wells, Elena L Pobezinskaya
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Frontiers in Immunology
Frontiers in Immunology
Multiple sclerosis (MS) is a disabling demyelinating autoimmune disorder of the central nervous system (CNS) which is driven by IL-23- and IL-1β-induced autoreactive Th17 cells that traffic to the CNS and secrete proinflammatory cytokines. Th17 path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57195c5dff171925719f7baa9d31e133
https://doi.org/10.3389/fimmu.2019.03125
https://doi.org/10.3389/fimmu.2019.03125
Autor:
Antonio Pannuti, Rebecca G. Lawlor, Lisa M. Minter, Karthik Chandiran, Todd E. Golde, Lucio Miele, Janani Srinivasan, Barbara A. Osborne, Gabriela Gonzalez Perez
Publikováno v:
Molecular Immunology. 99:191-198
The transmembrane receptor, Notch1 plays an important role during the differentiation of CD4 T cells into T helper (Th) subsets in the presence of appropriate cytokines, including differentiation into Th1 cells. MicroRNAs have also been shown to be i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5eb4a7c8a1aafb3fecdbd9db6a52434
https://doi.org/10.1016/j.molimm.2018.05.002
https://doi.org/10.1016/j.molimm.2018.05.002
Autor:
Amy S. Burnside, Daniel T. Garrigan, Jyothi Vijayaraghavan, E. Ilker Ozay, Gregory N. Tew, Lisa M. Minter, Gabriela Gonzalez-Perez, Heather L. Sherman, Joe A. Torres, Barbara A. Osborne, Rebecca G. Lawlor
Targeting cellular proteins with antibodies, to better understand cellular signaling pathways in the context of disease modulation, is a fast-growing area of investigation. Humanized antibodies are increasingly gaining attention for their therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d4eb48bbc85393ce0d5fa607ec1b34
https://europepmc.org/articles/PMC5167783/
https://europepmc.org/articles/PMC5167783/
Autor:
Ignacio J. Juncadella, Lucio Miele, Shilpa Keerthivasan, Rebecca G. Lawlor, Lisa M. Minter, Justine E. Roderick, Barbara A. Osborne, Tonya C. Bates, Reem Suleiman, Brian J. Nickoloff, I. Caroline Le Poole, Juan Anguita
Publikováno v:
The Journal of Immunology. 187:692-701
Th17 cells are known to play a critical role in adaptive immune responses to several important extracellular pathogens. Additionally, Th17 cells are implicated in the pathogenesis of several autoimmune and inflammatory disorders as well as in cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60ef7058c83e3ba5e0f48c386fdbe31
https://doi.org/10.4049/jimmunol.1003658
https://doi.org/10.4049/jimmunol.1003658
Autor:
Kannan Natarajan, David H. Margulies, Nalini Shah-Mahoney, Barbara A. Osborne, Richard A. Goldsby, David I. Ratner, Govindarajan Rajagopalan, Rebecca G. Lawlor, Mulualem E. Tilahun, Chen Xie, Ashenafi Y. Tilahun
Publikováno v:
Infection and Immunity. 78:2801-2811
Staphylococcal enterotoxin B (SEB), a shock-inducing exotoxin synthesized byStaphylococcus aureus, is an important cause of food poisoning and is a class B bioterrorism agent. SEB mediates antigen-independent activation of a major subset of the T-cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad05508672d765b2ca192ab1acdd2de
https://doi.org/10.1128/iai.01121-09
https://doi.org/10.1128/iai.01121-09
Autor:
Barbara A. Osborne, Ellen S. Dickinson, Richard B. Arenas, Elizabeth A. Xavier, D. Joseph Jerry, Rebecca G. Lawlor, Frances S. Kittrell, Qing J. Cao, Jae Hong Seo, Daniel Medina, Haoheng Yan, S. Christine McLary, Christopher N. Otis, Amy L. Roberts, Anneke C. Blackburn, Luwei Tao
Publikováno v:
The American Journal of Pathology. 176:1421-1432
Mutation and loss of function in p53 are common features among human breast cancers. Here we use BALB/c-Trp53+/- mice as a model to examine the sequence of events leading to mammary tumors. Mammary gland proliferation rates were similar in both BALB/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bafd12102ad801202f173402b784e0c
https://doi.org/10.2353/ajpath.2010.090438
https://doi.org/10.2353/ajpath.2010.090438
Autor:
Stephen D. Miller, Pritam Das, Ok Hyun Cho, Todd E. Golde, Tanapat Palaga, Barbara A. Osborne, Hyun Mu Shin, Abdul H. Fauq, Lucio Miele, Katherine Simpson, Sridevi Gottipati, Danielle M. Turley, Ila Joshi, Lisa A. Kostura, Lisa M. Minter, Janice C. Telfer, Kimberly A Such, Rebecca G. Lawlor
Publikováno v:
Nature Immunology. 6:680-688
Notch receptors are processed by gamma-secretase acting in synergy with T cell receptor signaling to sustain peripheral T cell activation. Activated CD4+ T cells differentiate into T helper type 1 (TH1) or TH2 subsets. Molecular cues directing TH1 di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de262b9a6cb8f4164e166cff000664d0
https://doi.org/10.1038/ni1209x
https://doi.org/10.1038/ni1209x