Výsledky vyhledávání - "Rebecca G Smith"

Akademický článek

The histone modification H3K4me3 is altered at the ANK1 locus in Alzheimer's disease brain

Autor: Adam R Smith, Rebecca G Smith, Ruby Macdonald, Sarah J Marzi, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Jonathan Mill, Katie Lunnon

Publikováno v: Future Science OA, Vol 7, Iss 4 (2021)

Several epigenome-wide association studies of DNA methylation have highlighted altered DNA methylation in the ANK1 gene in Alzheimer's disease (AD) brain samples. However, no study has specifically examined ANK1 histone modifications in the disease.

Externí odkaz: https://doaj.org/article/e8edfd606bbb46548e6a839ae3c45883

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Akademický článek

Advancing paternal age is associated with deficits in social and exploratory behaviors in the offspring: a mouse model.

Autor: Rebecca G Smith, Rachel L Kember, Jonathan Mill, Cathy Fernandes, Leonard C Schalkwyk, Joseph D Buxbaum, Abraham Reichenberg

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8456 (2009)

BACKGROUND: Accumulating evidence from epidemiological research has demonstrated an association between advanced paternal age and risk for several psychiatric disorders including autism, schizophrenia and early-onset bipolar disorder. In order to est

Externí odkaz: https://doaj.org/article/b99335b2cadc4f55a7adedc93885ba15

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Akademický článek

Genome-wide characterization of mitochondrial DNA methylation in human brain

Autor: Matthew Devall, Darren M. Soanes, Adam R. Smith, Emma L. Dempster, Rebecca G. Smith, Joe Burrage, Artemis Iatrou, Eilis Hannon, Claire Troakes, Karen Moore, Paul O’Neill, Safa Al-Sarraj, Leonard Schalkwyk, Jonathan Mill, Michael Weedon, Katie Lunnon

Publikováno v: Frontiers in Endocrinology, Vol 13 (2023)

BackgroundThere is growing interest in the role of DNA methylation in regulating the transcription of mitochondrial genes, particularly in brain disorders characterized by mitochondrial dysfunction. Here, we present a novel approach to interrogate th

Externí odkaz: https://doaj.org/article/76c6f9056010427380458856bb8a4059

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Akademický článek

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

Autor: Adam R. Smith, Rebecca G. Smith, Ehsan Pishva, Eilis Hannon, Janou A. Y. Roubroeks, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Carolyn Sloan, Jonathan Mill, Daniel L. van den Hove, Katie Lunnon

Publikováno v: Clinical Epigenetics, Vol 11, Iss 1, Pp 1-13 (2019)

Abstract Background Alzheimer’s disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in Alzheimer’s disease have been unable to distinguish between DNA m

Externí odkaz: https://doaj.org/article/a2d864d64def4e4f9da5378cdfdff5c4

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