Zobrazeno 1 - 10 of 79 pro vyhledávání: '"Rebecca G, Smith"'
1
Akademický článek
DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types
Autor: Gemma Shireby, Emma L. Dempster, Stefania Policicchio, Rebecca G. Smith, Ehsan Pishva, Barry Chioza, Jonathan P. Davies, Joe Burrage, Katie Lunnon, Dorothea Seiler Vellame, Seth Love, Alan Thomas, Keeley Brookes, Kevin Morgan, Paul Francis, Eilis Hannon, Jonathan Mill
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Here the authors identify differences in cortical DNA methylation associated with Alzheimer’s disease pathology, and profiling nuclei from specific cell-types, find that most of these differences reflect variation occurring in non-neuronal cells.
Externí odkaz: https://doaj.org/article/4898751694c340419ac1ca01ad423bfa
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2
Akademický článek
Genome-wide characterization of mitochondrial DNA methylation in human brain
Autor: Matthew Devall, Darren M. Soanes, Adam R. Smith, Emma L. Dempster, Rebecca G. Smith, Joe Burrage, Artemis Iatrou, Eilis Hannon, Claire Troakes, Karen Moore, Paul O’Neill, Safa Al-Sarraj, Leonard Schalkwyk, Jonathan Mill, Michael Weedon, Katie Lunnon
Publikováno v: Frontiers in Endocrinology, Vol 13 (2023)
BackgroundThere is growing interest in the role of DNA methylation in regulating the transcription of mitochondrial genes, particularly in brain disorders characterized by mitochondrial dysfunction. Here, we present a novel approach to interrogate th
Externí odkaz: https://doaj.org/article/76c6f9056010427380458856bb8a4059
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3
Akademický článek
A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex
Autor: Rebecca G. Smith, Ehsan Pishva, Gemma Shireby, Adam R. Smith, Janou A. Y. Roubroeks, Eilis Hannon, Gregory Wheildon, Diego Mastroeni, Gilles Gasparoni, Matthias Riemenschneider, Armin Giese, Andrew J. Sharp, Leonard Schalkwyk, Vahram Haroutunian, Wolfgang Viechtbauer, Daniel L. A. van den Hove, Michael Weedon, Danielle Brokaw, Paul T. Francis, Alan J. Thomas, Seth Love, Kevin Morgan, Jörn Walter, Paul D. Coleman, David A. Bennett, Philip L. De Jager, Jonathan Mill, Katie Lunnon
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Although epigenome-wide association studies of Alzheimer’s disease have highlighted neuropathology-associated DNA methylation differences, previous studies have been limited in sample size and brain region used. Here, the authors combine data from
Externí odkaz: https://doaj.org/article/dd2f5bd2ef1b4cbabe97720ed844e0d6
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4
Akademický článek
Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease
Autor: Adam R. Smith, Rebecca G. Smith, Ehsan Pishva, Eilis Hannon, Janou A. Y. Roubroeks, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Carolyn Sloan, Jonathan Mill, Daniel L. van den Hove, Katie Lunnon
Publikováno v: Clinical Epigenetics, Vol 11, Iss 1, Pp 1-13 (2019)
Abstract Background Alzheimer’s disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in Alzheimer’s disease have been unable to distinguish between DNA m
Externí odkaz: https://doaj.org/article/a2d864d64def4e4f9da5378cdfdff5c4
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5
Akademický článek
The histone modification H3K4me3 is altered at the ANK1 locus in Alzheimer's disease brain
Autor: Adam R Smith, Rebecca G Smith, Ruby Macdonald, Sarah J Marzi, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Jonathan Mill, Katie Lunnon
Publikováno v: Future Science OA, Vol 7, Iss 4 (2021)
Several epigenome-wide association studies of DNA methylation have highlighted altered DNA methylation in the ANK1 gene in Alzheimer's disease (AD) brain samples. However, no study has specifically examined ANK1 histone modifications in the disease.
Externí odkaz: https://doaj.org/article/e8edfd606bbb46548e6a839ae3c45883
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6
Akademický článek
Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue
Autor: Matthew Devall, Rebecca G. Smith, Aaron Jeffries, Eilis Hannon, Matthew N. Davies, Leonard Schalkwyk, Jonathan Mill, Michael Weedon, Katie Lunnon
Publikováno v: Clinical Epigenetics, Vol 9, Iss 1, Pp 1-15 (2017)
Abstract Background DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases. Mitochondrial DNA methylation is a phenomenon t
Externí odkaz: https://doaj.org/article/945ea65b766b4c2fbd4624efbe9dede7
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