Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Rebecca F Halperin"'
Autor:
Michael E Berens, Anup Sood, Jill S Barnholtz-Sloan, John F Graf, Sanghee Cho, Seungchan Kim, Jeffrey Kiefer, Sara A Byron, Rebecca F Halperin, Sara Nasser, Jonathan Adkins, Lori Cuyugan, Karen Devine, Quinn Ostrom, Marta Couce, Leo Wolansky, Elizabeth McDonough, Shannon Schyberg, Sean Dinn, Andrew E Sloan, Michael Prados, Joanna J Phillips, Sarah J Nelson, Winnie S Liang, Yousef Al-Kofahi, Mirabela Rusu, Maria I Zavodszky, Fiona Ginty
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0219724 (2019)
Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the genetically-bifurcated IDH1 mutant
Externí odkaz:
https://doaj.org/article/1e809134b36d47c88e669627661aa0b7
Autor:
Giselle L. Saulnier Sholler, Genevieve Bergendahl, Elizabeth C. Lewis, Jacqueline Kraveka, William Ferguson, Abhinav B. Nagulapally, Karl Dykema, Valerie I. Brown, Michael S. Isakoff, Joseph Junewick, Deanna Mitchell, Jawhar Rawwas, William Roberts, Don Eslin, Javier Oesterheld, Randal K. Wada, Devang Pastakia, Virginia Harrod, Kevin Ginn, Raya Saab, Kevin Bielamowicz, Jason Glover, Eugenia Chang, Gina K. Hanna, Daniel Enriquez, Tyler Izatt, Rebecca F. Halperin, Abigail Moore, Sara A. Byron, William P. D. Hendricks, Jeffrey M. Trent
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background Children with relapsed central nervous system (CNS tumors), neuroblastoma, sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial examined the feasibility of combining genomic and transcriptomic
Externí odkaz:
https://doaj.org/article/aabaaa1d731d43219ab2b7d7fb61c753
Autor:
Rebecca F. Halperin, Winnie S. Liang, Sidharth Kulkarni, Erica E. Tassone, Jonathan Adkins, Daniel Enriquez, Nhan L. Tran, Nicole C. Hank, James Newell, Chinnappa Kodira, Ronald Korn, Michael E. Berens, Seungchan Kim, Sara A. Byron
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Archival tumor samples represent a rich resource of annotated specimens for translational genomics research. However, standard variant calling approaches require a matched normal sample from the same individual, which is often not available in the re
Externí odkaz:
https://doaj.org/article/90752cb6e59f42ef8714545632c313ad
Autor:
Michael D. Prados, David W. Craig, John D. Carpten, Michael E. Berens, Jeffrey M. Trent, Winnie S. Liang, Sara Nasser, Sen Peng, Gerald M. Maggiora, Annette M. Molinaro, Mitchel S. Berger, Susan M. Chang, Jennifer L. Clarke, Jennie W. Taylor, Nicholas A. Butowski, Ingo K. Mellinghoff, Timothy F. Cloughesy, Patrick Y. Wen, Keith L. Ligon, Howard Colman, John F. de Groot, John G. Kuhn, Joanna J. Phillips, Rebecca F. Halperin, Nhan L. Tran, Sara A. Byron
Study Workflow Diagram. Key steps in the study are outlined, including the number of patients at each stage. BEV: bevacizumab.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda8dbd25cdfe81cd1161fd83f3186ed
https://doi.org/10.1158/1078-0432.22466372
https://doi.org/10.1158/1078-0432.22466372
Autor:
Jeffrey M. Trent, Giselle L. Saulnier Sholler, Javed Khan, Rebecca F. Halperin, Jonathan J. Keats, Szabolcs Szelinger, Bryce Turner, Austin Christofferson, Faith Cisneros, Apurva M. Hegde, Daniel Enriquez, Tyler Izatt, Sara Nasser, Alison Roos, Hue V. Reardon, Xinyu Wen, Jun S. Wei, Hsien-Chao Chou, Jeffrey Bond, Karl Dykema, Elizabeth VanSickle, Genevieve Bergendahl, Virginia L. Harrod, Peter E. Zage, Kathleen Neville, Jawhar Rawwas, Randal K. Wada, Javier E. Oesterheld, Michael S. Isakoff, William Roberts, Albert Cornelius, Deanna Mitchell, Don E. Eslin, Valerie I. Brown, William S. Ferguson, Jacqueline M. Kraveka, Abhinav B. Nagulapally, William P.D. Hendricks, Sara A. Byron
Additional Longitudinal Analysis of Relapsed and Refractory Childhood Solid Tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358f5743a8a96e060a39f9e37a70c1e5
https://doi.org/10.1158/0008-5472.22431250.v1
https://doi.org/10.1158/0008-5472.22431250.v1
Autor:
Jeffrey M. Trent, Giselle L. Saulnier Sholler, Javed Khan, Rebecca F. Halperin, Jonathan J. Keats, Szabolcs Szelinger, Bryce Turner, Austin Christofferson, Faith Cisneros, Apurva M. Hegde, Daniel Enriquez, Tyler Izatt, Sara Nasser, Alison Roos, Hue V. Reardon, Xinyu Wen, Jun S. Wei, Hsien-Chao Chou, Jeffrey Bond, Karl Dykema, Elizabeth VanSickle, Genevieve Bergendahl, Virginia L. Harrod, Peter E. Zage, Kathleen Neville, Jawhar Rawwas, Randal K. Wada, Javier E. Oesterheld, Michael S. Isakoff, William Roberts, Albert Cornelius, Deanna Mitchell, Don E. Eslin, Valerie I. Brown, William S. Ferguson, Jacqueline M. Kraveka, Abhinav B. Nagulapally, William P.D. Hendricks, Sara A. Byron
Table S1. Extended Cohort Annotations. Table S2. Mutational Signatures. Table S3. GISTIC Copy Number Analysis. Table S4. Somatic Variants in Relapsed/Refractory Childhood Solid Tumors (n=184 Patients with T/N WES). Table S5. Clinvar Pathogenic and Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e39ae7fd69f2b814d3c10f93f7f3e1
https://doi.org/10.1158/0008-5472.22431247.v1
https://doi.org/10.1158/0008-5472.22431247.v1
Autor:
Michael D. Prados, David W. Craig, John D. Carpten, Michael E. Berens, Jeffrey M. Trent, Winnie S. Liang, Sara Nasser, Sen Peng, Gerald M. Maggiora, Annette M. Molinaro, Mitchel S. Berger, Susan M. Chang, Jennifer L. Clarke, Jennie W. Taylor, Nicholas A. Butowski, Ingo K. Mellinghoff, Timothy F. Cloughesy, Patrick Y. Wen, Keith L. Ligon, Howard Colman, John F. de Groot, John G. Kuhn, Joanna J. Phillips, Rebecca F. Halperin, Nhan L. Tran, Sara A. Byron
Purpose: Glioblastoma is an aggressive and molecularly heterogeneous cancer with few effective treatment options. We hypothesized that next-generation sequencing can be used to guide treatment recommendations within a clinically acceptable time frame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d428228d409e48210b0352b02b3c1b2
https://doi.org/10.1158/1078-0432.c.6526301
https://doi.org/10.1158/1078-0432.c.6526301
Autor:
Jeffrey M. Trent, Giselle L. Saulnier Sholler, Javed Khan, Rebecca F. Halperin, Jonathan J. Keats, Szabolcs Szelinger, Bryce Turner, Austin Christofferson, Faith Cisneros, Apurva M. Hegde, Daniel Enriquez, Tyler Izatt, Sara Nasser, Alison Roos, Hue V. Reardon, Xinyu Wen, Jun S. Wei, Hsien-Chao Chou, Jeffrey Bond, Karl Dykema, Elizabeth VanSickle, Genevieve Bergendahl, Virginia L. Harrod, Peter E. Zage, Kathleen Neville, Jawhar Rawwas, Randal K. Wada, Javier E. Oesterheld, Michael S. Isakoff, William Roberts, Albert Cornelius, Deanna Mitchell, Don E. Eslin, Valerie I. Brown, William S. Ferguson, Jacqueline M. Kraveka, Abhinav B. Nagulapally, William P.D. Hendricks, Sara A. Byron
Children with treatment-refractory or relapsed (R/R) tumors face poor prognoses. As the genomic underpinnings driving R/R disease are not well defined, we describe here the genomic and transcriptomic landscapes of R/R solid tumors from 202 patients e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f3927cdafa8ff7060a5a484ff93c70c
https://doi.org/10.1158/0008-5472.c.6513853.v1
https://doi.org/10.1158/0008-5472.c.6513853.v1
Autor:
Rebecca F. Halperin, Apurva Hegde, Jessica D. Lang, Elizabeth A. Raupach, C4RCD Research Group, Christophe Legendre, Winnie S. Liang, Patricia M. LoRusso, Aleksandar Sekulic, Jeffrey A. Sosman, Jeffrey M. Trent, Sampathkumar Rangasamy, Patrick Pirrotte, Nicholas J. Schork
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
The robust detection of disease-associated splice events from RNAseq data is challenging due to the potential confounding effect of gene expression levels and the often limited number of patients with relevant RNAseq data. Here we present a novel sta
Autor:
Faith Cisneros, Austin Christofferson, Deanna Mitchell, Jawhar Rawwas, Don E Eslin, Randal K. Wada, Javier Oesterheld, Genevieve Bergendahl, Xinyu Wen, Jun S. Wei, Hue V. Reardon, Tyler Izatt, Jeffrey M. Trent, William Roberts, William P.D. Hendricks, Virginia L Harrod, Karl Dykema, Sara Nasser, Sara A. Byron, Elizabeth VanSickle, Bryce Turner, Jacqueline M. Kraveka, Peter E. Zage, Alison Roos, Apurva M. Hegde, Valerie I. Brown, Kathleen A. Neville, Albert Cornelius, Jonathan J Keats, Szabolcs Szelinger, Rebecca F. Halperin, Michael S. Isakoff, William S. Ferguson, Daniel Enriquez, Javed Khan, Abhinav Nagulapally, Jeffrey P. Bond, Hsien-Chao Chou, Giselle Saulnier Sholler
Publikováno v:
Cancer Res
Cancer research, vol 81, iss 23
Cancer research, vol 81, iss 23
Children with treatment-refractory or relapsed (R/R) tumors face poor prognoses. As the genomic underpinnings driving R/R disease are not well defined, we describe here the genomic and transcriptomic landscapes of R/R solid tumors from 202 patients e