Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rebecca E. Silberman"'
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6536, p 6536 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Prions are infectious proteins that self-propagate by changing from their normal folded conformation to a misfolded conformation. The misfolded conformation, which is typically rich in β-sheet, serves as a template to convert the prion protein into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70ea5701c6d58629b26d9c659fddfb8
https://www.mdpi.com/1422-0067/21/18/6536
https://www.mdpi.com/1422-0067/21/18/6536
Autor:
Kelly Higa, Andrii I. Rozhok, Rebecca E. Silberman, James DeGregori, Angelika Amon, L. Alex Liggett
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Aneuploidy is a feature of many cancers. Recent studies demonstrate that in the hematopoietic stem and progenitor cell (HSPC) compartment aneuploid cells have reduced fitness and are efficiently purged from the bone marrow. However, early phases of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3ef78831196f3b90bd6354998f6738
http://europepmc.org/articles/PMC7376010
http://europepmc.org/articles/PMC7376010
Autor:
Ravindra Mylavagnanam, Sridhar Ramaswamy, Elena Zarcaro, Srinivas Vinod Saladi, Andrea Desmond, Murat Yildirim, Varunika Vivekanandan, Michael S. Lawrence, Kenneth N. Ross, Mihriban Karaayvaz-Yildirim, Rebecca E. Silberman, Adam Langenbucher, Leif W. Ellisen, Angelika Amon, Michelle C. Specht, Hiranmayi Ravichandran
Publikováno v:
Science Advances. 6
Women harboring heterozygous germline mutations of BRCA2 have a 50 to 80% risk of developing breast cancer, yet the pathogenesis of these cancers is poorly understood. To reveal early steps in BRCA2-associated carcinogenesis, we analyzed sorted cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beca88611b3ab78e16a2b91b216ce615
https://doi.org/10.1126/sciadv.aay2611
https://doi.org/10.1126/sciadv.aay2611
Autor:
Kaelyn C. Cummins, Sheela Saidha, Ramon Rodriguez, Lois E. Greene, Rebecca E. Silberman, Joseph M. Ahearn, Evan Eisenberg, Xiaohong Zhao
Publikováno v:
Journal of Biological Chemistry. 292:8630-8641
Prions arise from proteins that have two possible conformations: properly folded and non-infectious or misfolded and infectious. The [PSI+] yeast prion, which is the misfolded and self-propagating form of the translation termination factor eRF3 (Sup3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b11273a8c771b3590f3ba1e284e921e1
https://doi.org/10.1074/jbc.m116.770719
https://doi.org/10.1074/jbc.m116.770719
Autor:
Michelle C. Specht, Murat Yildirim, Michael S. Lawrence, Mihriban Karaayvaz, Srinivas Vinod Saladi, Angelika Amon, Adam Langenbucher, Rebecca E. Silberman, Varunika Vivekanandan, Andrea Desmond, Leif W. Ellisen, Sridhar Ramaswamy, Kenneth N. Ross, Ravindra Mylavagnanam, Elena Zarcaro, Hiranmayi Ravichandran
Women harboring heterozygous germline mutations of BRCA2 have a 50-80% risk of developing breast cancer, yet the early pathogenesis of these cancers is poorly understood. We sought to reveal early steps in BRCA2-associated carcinogenesis through anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7aca1536bb1e9698d683f92a1ea1e17
https://doi.org/10.1101/729301
https://doi.org/10.1101/729301
Autor:
Mihriban, Karaayvaz-Yildirim, Rebecca E, Silberman, Adam, Langenbucher, Srinivas Vinod, Saladi, Kenneth N, Ross, Elena, Zarcaro, Andrea, Desmond, Murat, Yildirim, Varunika, Vivekanandan, Hiranmayi, Ravichandran, Ravindra, Mylavagnanam, Michelle C, Specht, Sridhar, Ramaswamy, Michael, Lawrence, Angelika, Amon, Leif W, Ellisen
Publikováno v:
Science Advances
Normal breast epithelia from BRCA2 mutation carriers display DNA damage and attenuated checkpoint responses.
Women harboring heterozygous germline mutations of BRCA2 have a 50 to 80% risk of developing breast cancer, yet the pathogenesis of thes
Women harboring heterozygous germline mutations of BRCA2 have a 50 to 80% risk of developing breast cancer, yet the pathogenesis of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05689daf93f4246b17f7b6ac401b1f9b
https://pubmed.ncbi.nlm.nih.gov/32064343
https://pubmed.ncbi.nlm.nih.gov/32064343
Aneuploidy is associated with many cancers. Recent studies demonstrate that in thehematopoietic stem and progenitor cell (HSPC) compartment aneuploid cells havereduced fitness and are efficiently purged from the bone marrow. However, early phasesof h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33d8329e34dd0e45367711ed6d29537
Autor:
Xiaohong, Zhao, Ramon, Rodriguez, Rebecca E, Silberman, Joseph M, Ahearn, Sheela, Saidha, Kaelyn C, Cummins, Evan, Eisenberg, Lois E, Greene
Publikováno v:
The Journal of biological chemistry. 292(21)
Prions arise from proteins that have two possible conformations: properly folded and non-infectious or misfolded and infectious. The [PSI+] yeast prion, which is the misfolded and self-propagating form of the translation termination factor eRF3 (Sup3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1e7c4c21df2107a0fe94cec1e7baf60
https://pubmed.ncbi.nlm.nih.gov/28373280
https://pubmed.ncbi.nlm.nih.gov/28373280
Autor:
Pei-hsin Hsu, Rebecca E. Silberman, Angelika Amon, Christopher M. Brennan, Chiara Ricci-Tam, Michael Springer, Bo Hua, Christine A. Moomau, Rebecca R. Beach
Publikováno v:
PMC
Phenotypic variability is a hallmark of diseases involving chromosome gains and losses, such as Down syndrome and cancer. Allelic variances have been thought to be the sole cause of this heterogeneity. Here, we systematically examine the consequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff84f0843fed92e6cfe2df3cffee6a44
https://orcid.org/0000-0002-2345-5038
https://orcid.org/0000-0002-2345-5038
Publikováno v:
Cold Spring Harbor Laboratory Press
Aneuploidy, an imbalanced karyotype, is a widely observed feature of cancer cells that has long been hypothesized to promote tumorigenesis. Here we evaluate the fitness of cells with constitutional trisomy or chromosomal instability (CIN) in vivo usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d35afa4369a3cb8a57b3122213e31fa
http://hdl.handle.net/1721.1/108393
http://hdl.handle.net/1721.1/108393