Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Rebecca E. Schweppe"'
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
ABSTRACTThyroid cancer is one of the deadliest endocrine cancers, and its incidence has been increasing. While mutations in BRAF are common in thyroid cancer, advanced PTC patients currently lack therapeutic options targeting the MAPK pathway, and de
Externí odkaz:
https://doaj.org/article/bf71560a73dc416187643a132237b04a
Autor:
Eric L. Bolf, Thomas C. Beadnell, Madison M. Rose, Angelo D’Alessandro, Travis Nemkov, Kirk C. Hansen, Rebecca E. Schweppe
Publikováno v:
Cells, Vol 12, Iss 10, p 1374 (2023)
Thyroid cancer is the most common endocrine neoplasm, and despite its overall high survival rate, patients with metastatic disease or tumors that resist radioactive iodine experience a significantly worse prognosis. Helping these patients requires a
Externí odkaz:
https://doaj.org/article/2220e4d61c024f84a6358757d5a6ddd9
Autor:
William M. Wood, Vibha Sharma, Kevin T. Bauerle, Laura A. Pike, Qiong Zhou, Deborah L. Fretwell, Rebecca E. Schweppe, Bryan R. Haugen
Publikováno v:
PPAR Research, Vol 2011 (2011)
Undifferentiated (anaplastic) thyroid cancer (ATC) is one of the most aggressive human malignancies and no effective therapy is currently available. We show here that PPARγ levels are elevated in cells derived from ATC. Depletion of PPARγ in HTh74
Externí odkaz:
https://doaj.org/article/73f136048bcd471a8389a23be980c795
Autor:
Hannah M. Hicks, Nikita Pozdeyev, Sharon B. Sams, Umarani Pugazhenthi, Elise S. Bales, Marie-Claude Hofmann, Logan R. McKenna, Rebecca E. Schweppe
Publikováno v:
Molecular Cancer Research.
Mutations in BRAF are common in advanced papillary and anaplastic thyroid cancer (PTC and ATC). However, BRAF-mutant PTC patients currently lack therapies targeting this pathway. Despite the approved combination of BRAF and MEK1/2 inhibition for pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27e037156015ffb6bd0a093085ebcd4f
https://doi.org/10.1158/1541-7786.mcr-22-1031
https://doi.org/10.1158/1541-7786.mcr-22-1031
Autor:
Rebecca E. Schweppe, Sharon B. Sams, Anna A. Kerege, Laura A. Pike, Xia Jing, Qiong Zhou, Vibha Sharma, Brittelle E. Kessler
BCPAP and 8505C cells were plated in 96-well plates with or without fibronectin and exposed to the indicated concentrations of PF-573,228 for 5 days. Results shown are mean percent growth {plus minus} SD of 2 experiments performed in triplicate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047b4cf543661692987a5af93942c204
https://doi.org/10.1158/1541-7786.22514751.v1
https://doi.org/10.1158/1541-7786.22514751.v1
Autor:
Rebecca E. Schweppe, Aik Choon Tan, Guoliang Wang, Jihye Kim, Xia Jing, Maia L. Corpuz, Brittelle E. Kessler, Kelsey E. Wuensch, Stephen M. Riffert, Qiong Zhou, Katie M. Mishall, Thomas C. Beadnell
Tumor weights were measured upon euthanasia for both the Cal62 DasRes and Parental cell lines treated for 29 days with 1mg/kg QD trametinib. Data as means +/- SEM (n=8; student t-test; ***, P < 0.0005)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164d7e6f76f0ebab1bf5fc376403e940
https://doi.org/10.1158/1535-7163.22508268.v1
https://doi.org/10.1158/1535-7163.22508268.v1
Autor:
Rebecca E. Schweppe, Aik Choon Tan, Guoliang Wang, Jihye Kim, Xia Jing, Maia L. Corpuz, Brittelle E. Kessler, Kelsey E. Wuensch, Stephen M. Riffert, Qiong Zhou, Katie M. Mishall, Thomas C. Beadnell
A.) Densitometry quantification of ERK 1/2 phosphorylation. Fold changes were calculated based on the control cell lines being normalized to 1. Signals were normalized to α-tubulin. Quantification represents the mean of at least 3 separate experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b021bffbf86e5acae362abb95db5da
https://doi.org/10.1158/1535-7163.22508280
https://doi.org/10.1158/1535-7163.22508280
Autor:
Rebecca E. Schweppe, Sharon B. Sams, Anna A. Kerege, Laura A. Pike, Xia Jing, Qiong Zhou, Vibha Sharma, Brittelle E. Kessler
BCPAP and 8505C cells exposed to (A) 1uM PF-573,228 for 24 hours or those expressing (B) shFAK were assessed for migration through Matrigel-coated transwell chambers. Invaded cells treated with DMSO control or those expressing scrambled control were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053abadcab3febf1c953a09a1cb887ee
https://doi.org/10.1158/1541-7786.22514745
https://doi.org/10.1158/1541-7786.22514745
Autor:
Rebecca E. Schweppe, Aik Choon Tan, William Robinson, Mayumi Fujita, Tugs-Saikhan Chimed, Carol M. Amato, Christophe Langouët-Astrié, Veronica Espinoza, Stacey M. Bagby, Jennifer D. Hintzsche, Kelsey W. Nassar
Supplementary tables and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760aaab62a507382a0a78a11b93acee2
https://doi.org/10.1158/1535-7163.22521675
https://doi.org/10.1158/1535-7163.22521675
Autor:
Rebecca E. Schweppe, Aik Choon Tan, William Robinson, Mayumi Fujita, Tugs-Saikhan Chimed, Carol M. Amato, Christophe Langouët-Astrié, Veronica Espinoza, Stacey M. Bagby, Jennifer D. Hintzsche, Kelsey W. Nassar
WES MB1998 and MB2132
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05232e1bd504df9f7a1c9af177e9fd86
https://doi.org/10.1158/1535-7163.22521678
https://doi.org/10.1158/1535-7163.22521678