Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Rebecca E. McIntyre"'
Autor:
Werna T. C. Uniken Venema, Aarón D. Ramírez-Sánchez, Emilia Bigaeva, Sebo Withoff, Iris Jonkers, Rebecca E. McIntyre, Mennatallah Ghouraba, Tim Raine, Rinse K. Weersma, Lude Franke, Eleonora A. M. Festen, Monique G. P. van der Wijst
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Single-cell RNA sequencing (scRNA-seq) has revolutionized the study of the cellular landscape of organs. Most single-cell protocols require fresh material, which limits sample size per experiment, and consequently, introduces batch effects.
Externí odkaz:
https://doaj.org/article/ea1f79c0e77a4d50adbee714e2e2a5a2
Autor:
Matthew J. Sale, Kathryn Balmanno, Jayeta Saxena, Eiko Ozono, Katarzyna Wojdyla, Rebecca E. McIntyre, Rebecca Gilley, Anna Woroniuk, Karen D. Howarth, Gareth Hughes, Jonathan R. Dry, Mark J. Arends, Pilar Caro, David Oxley, Susan Ashton, David J. Adams, Julio Saez-Rodriguez, Paul D. Smith, Simon J. Cook
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-22 (2019)
Colorectal cancer cells can acquire resistance to MEK inhibition due to BRAF or KRAS amplification. Here, the authors show that while MEK inhibitor withdrawal in BRAF mutant cells restores sensitivity to the inhibitor through the loss of BRAF amplifi
Externí odkaz:
https://doaj.org/article/2c81d11afd5f46b09ea78ec188faf540
Autor:
Rebecca E. McIntyre, Jérôme Nicod, Carla Daniela Robles-Espinoza, John Maciejowski, Na Cai, Jennifer Hill, Ruth Verstraten, Vivek Iyer, Alistair G. Rust, Gabriel Balmus, Richard Mott, Jonathan Flint, David J. Adams
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 8, Pp 2343-2354 (2016)
In mammals the regulation of genomic instability plays a key role in tumor suppression and also controls genome plasticity, which is important for recombination during the processes of immunity and meiosis. Most studies to identify regulators of geno
Externí odkaz:
https://doaj.org/article/6b12f11393a14aaabd82a63bacdd0e90
Autor:
Peter M Irving, Miles Parkes, Ruth Wood, Ailsa L Hart, Nicholas A Kennedy, Nick Powell, Julian R Marchesi, Tariq Ahmad, Tim Raine, Andrew King, James O Lindsay, Kevin Whelan, Charlie W Lees, Christopher A Lamb, Jack Satsangi, Emma Clark, Shriya Sharma, Xinyue Zhang, Christopher J Stewart, Naomi McGregor, Helen C Hancock, Rebecca H Maier, John C Mansfield, Mary Doona, Michelle Bardgett, Natalie J Prescott, Trevor Liddle, Robert Lees, Hannah Watson, Carl A Anderson, Ally Speight, Ciara Kennedy, Sarah Lawrence, Nicola J Wyatt, Jennifer A Doyle, Rebecca E McIntyre, Luke Jostins-Dean, Victoria Hildreth, James MS Wason, Dean Allerton, Dawn Clewes, Cristina Cotobal Martin, Katherine Frith, Sameena Iqbal, Laura Letchford, Jasmin Ostermayer, Tolulope Osunnuyi, Tara Shrestha, Michelle Strickland, Gregory R Young
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Introduction Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient’s quality of life. Therapeutic developments
Externí odkaz:
https://doaj.org/article/12bb87e0caee4e31a4d86e9b0e5adbdd
Autor:
Jing Chen, Neil Ingham, Simon Clare, Claire Raisen, Valerie E. Vancollie, Ozama Ismail, Rebecca E. McIntyre, Stephen H. Tsang, Vinit B. Mahajan, Gordon Dougan, David J. Adams, Jacqueline K. White, Karen P. Steel
Publikováno v:
PLoS ONE, Vol 8, Iss 6 (2013)
Externí odkaz:
https://doaj.org/article/2b1cd17da8094f158965f50ce85ccebe
Autor:
James L Alexander, Nicola J Wyatt, Stephane Camuzeaux, Elena Chekmeneva, Beatriz Jimenez, Caroline J Sands, Hannah Fuller, Panteleimon Takis, Tariq Ahmad, Jennifer A Doyle, Ailsa Hart, Peter M Irving, Nicholas A Kennedy, Charlie W Lees, James O Lindsay, Rebecca E McIntyre, Miles Parkes, Natalie J Prescott, Tim Raine, Jack Satsangi, Richard Alexander Speight, Luke Jostins-Dean, Nick Powell, Julian R Marchesi, Christopher J Stewart, Christopher A Lamb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6f60356ae20c7a39e4120fc9f83ba0
http://hdl.handle.net/10044/1/102763
http://hdl.handle.net/10044/1/102763
Autor:
Nadia Akawi, James Stephenson, Jeffrey C. Barrett, Rebecca E. McIntyre, Hilary C. Martin, Sebastian S. Gerety, Matthew E. Hurles, Carla P. Jones, Diana S. Johnson, John Dean, Sarju G. Mehta, Elena Prigmore, Meena Balasubramanian, Rachel Horton, Michael Wright, Giuseppe Gallone, Mari Niemi, Miranda Splitt, Peter D. Turnpenny, Mark Sanderson, Dhavendra Kumar, Caroline F. Wright, Wendy D Jones, Pradeep C. Vasudevan, Andrew R. Bassett, Juliet Handsaker, Katie Johnson, Joanna Kaplanis, Alice Hulbert, Michaela Bruntraeger, Elizabeth J. Radford, Jenny Morton, Michael J. Parker, Helen V. Firth, Gabriela Sánchez-Andrade, Patrick J. Short, David R. FitzPatrick, Jeremy F. McRae, Sally Ann Lynch
Publikováno v:
2018, ' Quantifying the contribution of recessive coding variation to developmental disorders ', Science . https://doi.org/10.1126/science.aar6731
Genetic architecture of developmental disorders The genetics of developmental disorders (DDs) is complex. Martin et al. wanted to determine the degree of recessive inheritance of DDs in protein-coding genes. They examined the exomes of more than 6000
Autor:
Simon M. McHugh, Bill Davis, Liu He, Jackie Meakin, Paul A. Wilson, Sara Santos Franco, Thaddeus J. Carlson, Mercedes Lobera, Linda McCarthy, Justin P. Rubio, Sarah L. Spain, Rebecca E. McIntyre, Michael A. Nolan, Nicholas Galwey
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258316 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven inflammatory disease models were greatly diminished in RORC knock-out mice, this receptor was prior
Autor:
Yvette Hooks, Monika Tripathi, Carl A. Anderson, Sigurgeir Olafsson, Tim Raine, Michael R. Stratton, Tim H. H. Coorens, Claire Dawson, Philip S. Robinson, Miles Parkes, Kenneth Arestang, Peter J. Campbell, Mathijs A. Sanders, Rebecca E. McIntyre, Konstantina Strongili, Inigo Martincorena, Hyunchul Jung, Henry Lee-Six, Tim Butler
Publikováno v:
Cell
Cell, 182(3), 672-684.e11. Cell Press
Cell, 182(3), 672-684.e11. Cell Press
Summary Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts from 46 IBD patients and compared these to 412 crypts from 41 non-IBD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d760bc4c98ffcfdf2b87e1c6a33ce6
https://doi.org/10.1101/832014
https://doi.org/10.1101/832014
Autor:
Inigo Martincorena, Tim H. H. Coorens, Michael R. Stratton, Tim Butler, Konstantina Strongili, Carl A. Anderson, Philip Robinson, Henry Lee-Six, Tim Raine, Rebecca E. McIntyre, Sigurgeir Olafsson, Yvette Hooks, Monika Tripathi, Mathijs A. Sanders, Kenneth Arestang, Miles Parkes, Claire Dawson, Peter J. Campbell
Publikováno v:
Journal of Crohn's and Colitis. 14:S088-S089
Background Under normal physiological conditions, colonic crypts accrue ~40 somatic mutations for every year of life. That somatic mutations contribute to the development of cancer is well established, but their patterns, burden and functional conseq