Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rebecca E. K. Mandt"'
Publikováno v:
MIT Science Policy Review. 1:44-54
The U.S. government’s financial commitment to scientific research has significantly declined in the past few decades. Recent research has also revealed a lack of public awareness of the importance of federal research and development (R&D) funding;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a40d8a1a281a34e70265d58af1580b3
https://doi.org/10.38105/spr.n463z4t1u8
https://doi.org/10.38105/spr.n463z4t1u8
Autor:
Marcus C. S. Lee, Edward Owen, James M. Murithi, Kerry McGowen, Beatriz Baragaña, Madeline R. Luth, Emma F. Carpenter, Jacquin C. Niles, Chris Walpole, Manu Vanaerschot, Rebecca E. K. Mandt, Sabine Ottilie, Ian H. Gilbert, Avinash S. Punekar, Charisse Flerida A. Pasaje, Krittikorn Kümpornsin, Aslı Akidil, João Pedro Pisco, Kelly Rubiano, Nimisha Mittal, David A. Fidock, Robert L. Summers, De Lin, Andy Plater, Sharon M. Shepherd, Elizabeth A. Winzeler, A. Hazel Dilmore, Andrew M. Shepherd, Amanda K. Lukens, Dyann F. Wirth, Madalyn Won, Josefine Striepen, Justin Munro, Manuel Llinás
Publikováno v:
Cell Chemical Biology. 29:191-201.e8
Summary We identify the Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS) as a druggable target, using genetic and chemical validation. In vitro evolution of resistance with two antiplasmodial drug-like compounds (MMV019721 and MMV084978) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e3028ee2d6c74bf0739d4ebecac7eb
https://doi.org/10.1016/j.chembiol.2021.07.010
https://doi.org/10.1016/j.chembiol.2021.07.010
Autor:
Delfina C. Segura, Sabine Ottilie, Dyann F. Wirth, Alba Pablos-Tanarro, Sara Viera, Rebecca E. K. Mandt, Noemi Magan, Tomoyo Sakata-Kato, Maria Jose Lafuente-Monasterio, Madeline R. Luth, Amanda K. Lukens, Francisco-Javier Gamo, Elizabeth A. Winzeler
Publikováno v:
Sci Transl Med
Resistance has developed in Plasmodium malaria parasites to every antimalarial drug in clinical use, prompting the need to characterize the pathways mediating resistance. Here, we report a framework for assessing development of resistance of Plasmodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127d5ee96687431f2ec7206e966055e9
https://doi.org/10.1126/scitranslmed.aav1636
https://doi.org/10.1126/scitranslmed.aav1636
Publikováno v:
Journal of Biological Chemistry. 288:22315-22323
Drosophila melanogaster Heterochromatin Protein 1a (HP1a) is an essential protein critical for heterochromatin assembly and regulation. Its chromo shadow domain (CSD) homodimerizes, a requirement for binding protein partners that contain a PXVXL moti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3384a6ec203eb4e029b8be5a350939c6
https://doi.org/10.1074/jbc.m113.468413
https://doi.org/10.1074/jbc.m113.468413
Autor:
Dae-Gon Ha, Adityarup Chakravorty, Michael B. Miller, Rebecca E. K. Mandt, Jeffrey S. Simske, Leah Imlay, Charlotte R. Feddersen, Rachel Weinstein, Vida Praitis, Sarah Kniss, Walter Liszewski, Alexander Sullivan-Wilson, Juliet Mushi, Angela Schacht Farrell, Tyson Stock
Publikováno v:
PLoS Genetics, Vol 9, Iss 5, p e1003506 (2013)
PLoS Genetics
PLoS Genetics
Maintaining levels of calcium in the cytosol is important for many cellular events, including cell migration, where localized regions of high calcium are required to regulate cytoskeletal dynamics, contractility, and adhesion. Studies show inositol-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28f36545980435fdb6fb033facac6ca
http://europepmc.org/articles/PMC3656159?pdf=render
http://europepmc.org/articles/PMC3656159?pdf=render