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pro vyhledávání: '"Rebecca E. Daniels"'
Autor:
Bruno D. Stuyvers, Rebecca E. Daniels, John J. McGuire, Vincenzo Sorrentino, Elizabeth W. Chia, Kazi T. Haq, Masahito Miura, Lawson Miller
Publikováno v:
Journal of Molecular and Cellular Cardiology. 104:31-42
Background Three distinct Ca 2 + release channels were identified in dog P-cells: the ryanodine receptor subtype 2 ( RyR2 ) was detected throughout the cell, while the ryanodine receptor subtype 3 ( RyR3 ) and inositol phosphate sensitive Ca 2 + rele
Autor:
Bruno D. Stuyvers, Masahito Miura, Rebecca E. Daniels, Henk E.D.J. ter Keurs, Lawson Miller, Kazi T. Haq, Sharene D. Bungay
Publikováno v:
The Journal of Physiology. 591:4301-4319
Key points • Abnormal oscillations of calcium (Ca2+) concentration in cardiac Purkinje cells (P-cells) have been associated with life-threatening arrhythmias, but the mechanism by which these cells control their Ca2+ level in normal conditions rema
Autor:
Rebecca E, Daniels, Kazi T, Haq, Lawson S, Miller, Elizabeth W, Chia, Masahito, Miura, Vincenzo, Sorrentino, John J, McGuire, Bruno D, Stuyvers
Publikováno v:
Journal of molecular and cellular cardiology. 104
Three distinct CaGene expression of CR channels was measured by qPCR in Purkinje fibers and myocardium of adult Yucatan pig hearts. We characterized the CR channels protein expression in isolated P-cells by immuno-fluorescence, laser scanning confoca
Publikováno v:
Biophysical Journal. 100(3)
In large mammals, cardiac Purkinje cells (Pcells) lack transverse tubules (T-tubules). However, Pcells respond to stimulations by massive Ca-releases from the sarcoplasmic reticulum (SR) similar to those of ventricular myocytes (VMs) with T-tubules.
Publikováno v:
Biophysical Journal. 104:439a
Rationale: Cai-variations in Purkinje cells (Pcells) can affect cardiac conduction by generating action potentials in Purkinje fibers thereby promoting arrhythmias. The system underlying Cai-variations in Pcells is still unknown. Upon stimulation, th