Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rebecca E, Audette"'
Autor:
Elinor Hortle, David I. Roper, Warwick J. Britton, Richard J. Payne, Gregory M. Cook, Wendy Tran, Paige M. E. Hawkins, Alexander Stoye, Christopher G. Dowson, Rebecca E Audette, Thomas Balle, Jessica L. Ochoa, Gayathri Nagalingam, Daniel J Ford, Ali Saad Kusay, Venugopal Pujari, Roger G. Linington, Chen-Yi Cheung, Dean C. Crick, Eric J. Rubin, Stefan H. Oehlers, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:17326-17345
Herein, we report the design and synthesis of inhibitors of Mycobacterium tuberculosis (Mtb) phospho-MurNAc-pentapeptide translocase I (MurX), the first membrane-associated step of peptidoglycan synthesis, leveraging the privileged structure of the s
Autor:
Wendy, Tran, Ali S, Kusay, Paige M E, Hawkins, Chen-Yi, Cheung, Gayathri, Nagalingam, Venugopal, Pujari, Daniel J, Ford, Alexander, Stoye, Jessica L, Ochoa, Rebecca E, Audette, Elinor, Hortle, Stefan H, Oehlers, Susan A, Charman, Roger G, Linington, Eric J, Rubin, Christopher G, Dowson, David I, Roper, Dean C, Crick, Thomas, Balle, Gregory M, Cook, Warwick J, Britton, Richard J, Payne
Publikováno v:
Journal of medicinal chemistry. 64(23)
Herein, we report the design and synthesis of inhibitors of
Autor:
Rebecca E Audette, David H Chan, Krystal A. Meza, Jennifer R. Blase, Richard J. DiPaolo, Christopher S. Eickhoff, Daniel F. Hoft, Catherine W. Cai, Kevin A. Bockerstett
Publikováno v:
Infect Immun
Trypanosoma cruzi is the intracellular parasite of Chagas disease, a chronic condition characterized by cardiac and gastrointestinal morbidity. Protective immunity requires CD4(+) T cells, and Th1 cells and gamma interferon (IFN-γ) are important pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020df46c1a911896fb4ce57d65ae21e7
https://europepmc.org/articles/PMC8208511/
https://europepmc.org/articles/PMC8208511/
Autor:
Dirk Schnappinger, Rebecca E Audette, Kristine M. Guinn, Michael Fitzgerald, Michelle Gardner, Carolina Trujillo, Joshua Davis, Joshua B. Wallach, Jessica T. Pinkham, Deborah T. Hung, Nirmalya Bandyopadhyay, Mary Stanley, Natalia Betancourt, Christina Gallo, Megan K. Proulx, Jennifer A McConnell, Christopher M. Sassetti, Sofia Kennedy, Elisabeth Meyer, James Gomez, Kayla Delano, Paula A Pino, Emily LaVerriere, K. G. Papavinasasundaram, Eric S. Lander, Eric J. Rubin, Michael H Serrano-Wu, Emma Office, Caitlin E Moss, Naomi Song, Nadine Ruecker, Thomas R. Ioerger, Israel Da Silva, Matthew Thompson, Christopher Watson, Sabine Ehrt, Shoko Wakabayashi, Brian K. Hubbard, Tomohiko Kawate, Kenan C. Murphy, Rebecca Korn, Raymond M. Nietupski, Eachan O. D. Johnson, Aaron Golas
Publikováno v:
Nature. 571:72-78
New antibiotics are needed to combat rising levels of resistance, with new Mycobacterium tuberculosis (Mtb) drugs having the highest priority. However, conventional whole-cell and biochemical antibiotic screens have failed. Here we develop a strategy
Autor:
Shant H. Mahrokhian, Eric J. Rubin, Sara B. Cohen, Noman Siddiqi, Rebecca E Audette, Rafael A. Larocca, Anne Devorak, Jingyou Yu, Eryn Blass, Dan H. Barouch, Kevin B. Urdahl, Amanda J. Martinot, Courtney R. Plumlee, Michelle Gardner, Malika Aid, Shoko Wakabayashi
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1009096 (2020)
PLoS Pathogens
PLoS Pathogens
Bacille Calmette-Guerin (BCG), an attenuated whole cell vaccine based on Mycobacterium bovis, is the only licensed vaccine against Mycobacterium tuberculosis (Mtb), but its efficacy is suboptimal and it fails to protect against pulmonary tuberculosis
Publikováno v:
Nature
The mycobacterial protein LamA functions as an inhibitor of cell wall synthesis at the nascent cell pole, contributing to asymmetry in polar growth, and could represent a much-needed target for the development of anti-tuberculosis therapies. Here the
Autor:
Laura McPartland, Jessica T. Pinkham, Cristina Landeta, Dana Boyd, Rebecca E Audette, Deepak Balasubramanian, Eric J. Rubin, Taehyun Kim, Ngoc Quang Tran, Brian M. Meehan, Yi-Fan Zhang, Jeremy M. Rock, Stephen Lory, Zaidi Tanweer, Shoko Wakabayashi, Gerald B. Pier, Melody Toosky, Jon Beckwith
Publikováno v:
Molecular microbiology. 111(4)
In bacteria, disulfide bonds confer stability on many proteins exported to the cell envelope or beyond, including bacterial virulence factors. Thus, proteins involved in disulfide bond formation represent good targets for the development of inhibitor
Autor:
Mary Stanley, Joshua B. Wallach, Michael H Serrano-Wu, Eachan O. D. Johnson, Paula A Pino, Aaron Golas, Rebecca Korn, Naomi Song, Caitlin E Moss, Eric S. Lander, Jessica T. Pinkham, Joshua Davis, Nadine Ruecker, Dirk Schnappinger, Christina Gallo, Tomohiko Kawate, Nirmalya Bandyopadhyay, Deborah T. Hung, Elisabeth Meyer, Michelle Gardner, Jennifer A McConnell, Thomas R. Ioerger, Carolina Trujillo, Megan K. Proulx, Israel Da Silva, Michael Fitzgerald, Kayla Delano, Emma Office, Kristine M. Guinn, Rebecca E Audette, Christopher Watson, K. G. Papavinasasundaram, Eric J. Rubin, Christopher M. Sassetti, Emily LaVerriere, Brian K. Hubbard, Ray Nietupski, Kenan C. Murphy, James Gomez, Matthew Thompson, Sabine Ehrt, Shoko Wakabayashi, Natalia Betancourt
New antibiotics are needed to combat rising resistance, with new Mycobacterium tuberculosis (Mtb) drugs of highest priority. Conventional whole-cell and biochemical antibiotic screens have failed. We developed a novel strategy termed PROSPECT (PRimar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1a1b6871077bae65e4d61671b2b402