Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rebecca Devine"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Formicapyridines are similar to pentacyclic fasamycin and formicamycin aromatic polyketides but with a pyridine moiety. Here the authors rationally mutate the biosynthetic gene cluster to increase production and identify a non-catalytic role for the
Externí odkaz:
https://doaj.org/article/8cf9bcdb3d87424c8659c18fd8f71d39
Publikováno v:
Antibiotics, Vol 8, Iss 2, p 83 (2019)
Discovering new antibiotics is vital to combat the growing threat of antimicrobial resistance. Most currently used antibiotics originate from the natural products of actinomycete bacteria, particularly Streptomyces species, that were discovered over
Externí odkaz:
https://doaj.org/article/ae91c6d407dd4043a58f797e0ae28408
Autor:
Morgan Anne, Feeney, Jake Terry, Newitt, Emily, Addington, Lis, Algora-Gallardo, Craig, Allan, Lucas, Balis, Anna S, Birke, Laia, Castaño-Espriu, Louise K, Charkoudian, Rebecca, Devine, Damien, Gayrard, Jacob, Hamilton, Oliver, Hennrich, Paul A, Hoskisson, Molly, Keith-Baker, Joshua G, Klein, Worarat, Kruasuwan, David R, Mark, Yvonne, Mast, Rebecca E, McHugh, Thomas C, McLean, Elmira, Mohit, John T, Munnoch, Jordan, Murray, Katie, Noble, Hiroshi, Otani, Jonathan, Parra, Camila F, Pereira, Louisa, Perry, Linamaria, Pintor-Escobar, Leighton, Pritchard, Samuel M M, Prudence, Alicia H, Russell, Jana K, Schniete, Ryan F, Seipke, Nelly, Sélem-Mojica, Agustina, Undabarrena, Kristiina, Vind, Gilles P, van Wezel, Barrie, Wilkinson, Sarah F, Worsley, Katherine R, Duncan, Lorena T, Fernández-Martínez, Matthew I, Hutchings
Publikováno v:
Microbial genomics. 8(7)
Actinobacteria is an ancient phylum of Gram-positive bacteria with a characteristic high GC content to their DNA. The ActinoBase Wiki is focused on the filamentous actinobacteria, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d868894d099c1cf135e38e8b12cb6b52
https://pubmed.ncbi.nlm.nih.gov/35775972
https://pubmed.ncbi.nlm.nih.gov/35775972
Autor:
Prantik Das, Rania Mohammed, Naveed Sarwar, Omar Din, Ankit Jain, Jessica Davies, Thangrarajh Mugunthan, Ajith Nair, Aruni Ghose, Seheli Bandyopadhyay, Roopesh Krishnappa, Pooja Iyer, Lauren Jones, Nikhil Vasdev, Maja Moldawa, Rebecca Devine, Robert Hughes, Anand Sharma
Publikováno v:
Journal of Clinical Oncology. 41:106-106
106 Background: Apalutamide plus androgen deprivation therapy(ADT) has been approved as a treatment option for castrate resistant non metastatic prostate cancer (nmCRPC) with a high risk of developing metastatic disease. It has also demonstrated bene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d196e01613d0de87c03fbe898927db34
https://doi.org/10.1200/jco.2023.41.6_suppl.106
https://doi.org/10.1200/jco.2023.41.6_suppl.106
Autor:
Sarah Howlett, India Reid, Andrew Gogbashian, Rebecca Devine, Linda Charalambous, Samita Agarwal, Anand Sharma
Publikováno v:
Journal of Clinical Oncology. 41:419-419
419 Background: Patients presenting with intermediate and poor risk germ cell tumours tend to be young and fit. Although more than half of patients may hope to be cured, a proportion will die because of their cancer. An aggressive strategy is require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a90ef455d359907608fed9056eeac9b9
https://doi.org/10.1200/jco.2023.41.6_suppl.419
https://doi.org/10.1200/jco.2023.41.6_suppl.419
Autor:
Barrie Wilkinson, Rebecca Devine, Zhiwei Qin, Govind Chandra, Hannah P. McDonald, Matthew I. Hutchings, Katie Noble, Corinne J. Arnold
The formicamycins are promising antibiotics with potent activity against Gram-positive pathogens including VRE and MRSA and display a high barrier to selection of resistant isolates. They were first identified in Streptomyces formicae KY5, which prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::616ee4d6844ab35ca0d2a1d28924dbf3
https://doi.org/10.1101/2020.09.15.275776
https://doi.org/10.1101/2020.09.15.275776
Autor:
Thomas J. Booth, Elliot H. E. Farrar, Rebecca Devine, Zhiwei Qin, Barrie Wilkinson, Matthew I. Hutchings, Matthew N. Grayson
Publikováno v:
Qin, Z, Devine, R, Booth, T J, Farrar, E H E, Grayson, M N, Hutchings, M I & Wilkinson, B 2020, ' Formicamycin biosynthesis involves a unique reductive ring contraction ', Chemical Science, vol. 11, no. 31, pp. 8125-8131 . https://doi.org/10.1039/D0SC01712D
Fasamycin natural products are biosynthetic precursors of the formicamycins. Both groups of compounds are polyketide natural products that exhibit potent antibacterial activity despite displaying different three-dimensional topologies. We show here t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe723ba3a179ef993a9ddb0859504516
https://ueaeprints.uea.ac.uk/id/eprint/75614/
https://ueaeprints.uea.ac.uk/id/eprint/75614/
Publikováno v:
Antibiotics
Antibiotics, Vol 8, Iss 2, p 83 (2019)
Antibiotics, Vol 8, Iss 2, p 83 (2019)
Discovering new antibiotics is vital to combat the growing threat of antimicrobial resistance. Most currently used antibiotics originate from the natural products of actinomycete bacteria, particularly Streptomyces species, that were discovered over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c8af3ceb11bc05a89b10c8366801f1
https://ueaeprints.uea.ac.uk/id/eprint/71520/
https://ueaeprints.uea.ac.uk/id/eprint/71520/
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The formicamycin biosynthetic gene cluster encodes two groups of type 2 polyketide antibiotics: the formicamycins and their biosynthetic precursors the fasamycins, both of which have activity against methicillin-resistant Staphylococcus aureus. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c082f3da202910bce3c22203ad6ae77
https://pubmed.ncbi.nlm.nih.gov/31399587
https://pubmed.ncbi.nlm.nih.gov/31399587