Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Rebecca Deprez"'
Publikováno v:
Cells, Vol 11, Iss 7, p 1228 (2022)
Insulin-degrading enzyme (IDE) is a multifunctional protease due to the variety of its substrates, its various cellular locations, its conservation between species and its many non-proteolytic functions. Numerous studies have successfully demonstrate
Externí odkaz:
https://doaj.org/article/ce739b9228324f75854e29e553800e2a
Autor:
Benoit Deprez, Damien Bosc, Julie Charton, Cyril Couturier, Rebecca Deprez-Poulain, Marion Flipo, Florence Leroux, Baptiste Villemagne, Nicolas Willand
Publikováno v:
Molecules, Vol 26, Iss 19, p 6083 (2021)
Chemical biology and drug discovery are two scientific activities that pursue different goals but complement each other. The former is an interventional science that aims at understanding living systems through the modulation of its molecular compone
Externí odkaz:
https://doaj.org/article/3139cdf061794c5db887520979edb00b
Autor:
Zhening Zhang, Wenguang G Liang, Lucas J Bailey, Yong Zi Tan, Hui Wei, Andrew Wang, Mara Farcasanu, Virgil A Woods, Lauren A McCord, David Lee, Weifeng Shang, Rebecca Deprez-Poulain, Benoit Deprez, David R Liu, Akiko Koide, Shohei Koide, Anthony A Kossiakoff, Sheng Li, Bridget Carragher, Clinton S Potter, Wei-Jen Tang
Publikováno v:
eLife, Vol 7 (2018)
Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type two diabetes, Alzheimer's, inflammation, and other human diseases. However, the process through which IDE recognizes peptides that tend to form amyloid fibrils remaine
Externí odkaz:
https://doaj.org/article/bdf640b40b944a06bfcc72ce62dd4071
Autor:
Virgyl Camberlein, Charlotte Fléau, Pierre Sierocki, Lenong Li, Ronan Gealageas, Damien Bosc, Valentin Guillaume, Sandrine Warenghem, Florence Leroux, Melissa Rosell, Keguang Cheng, Laura Medve, Mathilde Prigent, Myriam Decanter, Catherine Piveteau, Alexandre Biela, Maxime Eveque, Julie Dumont, Anastasia Mpakali, Petros Giastas, Adrien Herledan, Cyril Couturier, Jörg Haupenthal, Laetitia Lesire, Anna K. H. Hirsch, Benoit Deprez, Efstratios Stratikos, Marlene Bouvier, Rebecca Deprez‐Poulain
Publikováno v:
Angewandte Chemie. 134
Endoplasmic reticulum aminopeptidase 2 (ERAP2) is a key enzyme involved in the trimming of antigenic peptides presented by Major Histocompatibility Complex class I. It is a target of growing interest for the treatment of autoimmune diseases and in ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e811256da0e1a84c1cce3189a839b9
https://doi.org/10.1002/ange.202203560
https://doi.org/10.1002/ange.202203560
Autor:
Alice Legru, Federica Verdirosa, Yen Vo-Hoang, Giusy Tassone, Filippo Vascon, Caitlyn A. Thomas, Filomena Sannio, Giuseppina Corsica, Manuela Benvenuti, Georges Feller, Rémi Coulon, Francesca Marcoccia, Savannah Rowane Devente, Ezeddine Bouajila, Catherine Piveteau, Florence Leroux, Rebecca Deprez-Poulain, Benoît Deprez, Patricia Licznar-Fajardo, Michael W. Crowder, Laura Cendron, Cecilia Pozzi, Stefano Mangani, Jean-Denis Docquier, Jean-François Hernandez, Laurent Gavara
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16392-16419. ⟨10.1021/acs.jmedchem.2c01257⟩
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16392-16419. ⟨10.1021/acs.jmedchem.2c01257⟩
International audience; Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to preserve these important antibacterial drugs. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a12a2619992adab250d34ee8e40f7d5
https://hdl.handle.net/11577/3465209
https://hdl.handle.net/11577/3465209
Autor:
Julie Charton, Clara Maillard, Chau Phi Dinh, Adrien Herledan, Florence Leroux, Catherine Piveteau, Benoit Deprez, Isabelle Duplan, Nicolas Kraupner, Nathalie Hennuyer, Xiaoan Wen, Rebecca Deprez-Poulain, Damien Bosc, Sandrine Warenghem, Bart Staels, Valérie Landry
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2021, pp.113982. ⟨10.1016/j.ejmech.2021.113982⟩
European Journal of Medicinal Chemistry, Elsevier, 2021, pp.113982. ⟨10.1016/j.ejmech.2021.113982⟩
European Journal of Medicinal Chemistry, 2021, pp.113982. ⟨10.1016/j.ejmech.2021.113982⟩
European Journal of Medicinal Chemistry, Elsevier, 2021, pp.113982. ⟨10.1016/j.ejmech.2021.113982⟩
International audience; Insulin degrading enzyme (IDE) is a zinc metalloprotease that cleaves numerous substrates among which amyloid-β and insulin. It has been linked through genetic studies to the risk of type-2 diabetes (T2D) or Alzheimer's disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ed5fe0bfb1f46856b4bc660d9fb3a7
https://hal.science/hal-03430475
https://hal.science/hal-03430475
Autor:
Cyril Couturier, Baptiste Villemagne, Florence Leroux, Damien Bosc, Nicolas Willand, Rebecca Deprez-Poulain, Benoit Deprez, Marion Flipo, Julie Charton
Publikováno v:
Molecules
Molecules, Vol 26, Iss 6083, p 6083 (2021)
Molecules, Vol 26, Iss 6083, p 6083 (2021)
Chemical biology and drug discovery are two scientific activities that pursue different goals but complement each other. The former is an interventional science that aims at understanding living systems through the modulation of its molecular compone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43cc6fa33b9749010b111d8c8c41ffac
https://pubmed.ncbi.nlm.nih.gov/34641626
https://pubmed.ncbi.nlm.nih.gov/34641626
Autor:
Damien Bosc, Nour Bou Karroum, Nicolas Kraupner, Rebecca Deprez-Poulain, Virgyl Camberlein, Emmanuelle Lipka, Benoit Deprez
Publikováno v:
Tetrahedron Letters
Tetrahedron Letters, Elsevier, In press, ⟨10.1016/j.tetlet.2021.153131⟩
Tetrahedron Letters, In press, ⟨10.1016/j.tetlet.2021.153131⟩
Tetrahedron Letters, Elsevier, In press, ⟨10.1016/j.tetlet.2021.153131⟩
Tetrahedron Letters, In press, ⟨10.1016/j.tetlet.2021.153131⟩
International audience; An efficient one-pot procedure combining bromide conversion into azide followed by NiAAC for the preparation of 1,5-disubstituted 1,2,3-triazoles has been developed. This procedure prevents the use of isolated azides, which ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4073d9cbef3a3c5810b360cb55da35f4
https://hal.archives-ouvertes.fr/hal-03207833/file/Bosc_TetLett_revised.pdf
https://hal.archives-ouvertes.fr/hal-03207833/file/Bosc_TetLett_revised.pdf
Autor:
Aurore Lejeune-Dodge, Catherine Piveteau, Cyril Couturier, Sandrine Warenghem, Marine Andres, Alexandre Biela, Florence Leroux, Rebecca Deprez-Poulain, Adrien Herledan, Benoit Deprez
Publikováno v:
Slas Discovery
Slas Discovery, SAGE Publishing, 2019, 25 (2), pp.207-214. ⟨10.1177/2472555219897256⟩
Slas Discovery, 2019, 25 (2), pp.207-214. ⟨10.1177/2472555219897256⟩
Slas Discovery, SAGE Publishing, 2019, 25 (2), pp.207-214. ⟨10.1177/2472555219897256⟩
Slas Discovery, 2019, 25 (2), pp.207-214. ⟨10.1177/2472555219897256⟩
International audience; In the last 5 years, cellular thermal shift assay (CETSA), a technology based on ligand-induced changes in protein thermal stability, has been increasingly used in drug discovery to address the fundamental question of whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fb3fc2e2254cd9f2a5951af364a276
https://hal.archives-ouvertes.fr/hal-03051837
https://hal.archives-ouvertes.fr/hal-03051837
Autor:
Rebecca Deprez-Poulain
Publikováno v:
The 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery.
Target-guided synthesis has emerged as an elegant and efficient lead- and drug-discovery strategy. [...]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c51b71a84a546da1dc85261df951d1af
https://doi.org/10.3390/proceedings2019022117
https://doi.org/10.3390/proceedings2019022117