Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Rebecca Delaney"'
1
Akademický článek
Respiratory performance in Duchenne muscular dystrophy: Clinical manifestations and lessons from animal models
Autor: Rebecca Delaney, Ken D. O'Halloran
Publikováno v: Experimental Physiology, Vol 109, Iss 9, Pp 1426-1445 (2024)
Abstract Duchenne muscular dystrophy (DMD) is a fatal genetic neuromuscular disease. Lack of dystrophin in skeletal muscles leads to intrinsic weakness, injury, subsequent degeneration and fibrosis, decreasing contractile function. Dystropathology ev
Externí odkaz: https://doaj.org/article/3c6aa6a1728647ef881a5962656219f2
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2
Akademický článek
SLPI deficiency alters airway protease activity and induces cell recruitment in a model of muco-obstructive lung disease
Autor: Ryan Brown, Caoifa Dougan, Peter Ferris, Rebecca Delaney, Claire J. Houston, Aoife Rodgers, Damian G. Downey, Marcus A. Mall, Bronwen Connolly, Donna Small, Sinéad Weldon, Clifford C. Taggart
Publikováno v: Frontiers in Immunology, Vol 15 (2024)
Secretory leukocyte protease inhibitor (SLPI) is an important cationic protein involved in innate airway immunity and highly expressed in mucosal secretions, shown to target and inhibit neutrophil elastase (NE), cathepsin G and trypsin activity to li
Externí odkaz: https://doaj.org/article/438d37d1f0ab439ab6b29c4beb7f6c88
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3
Akademický článek
An explainable artificial intelligence approach for predicting cardiovascular outcomes using electronic health records.
Autor: Sergiusz Wesołowski, Gordon Lemmon, Edgar J Hernandez, Alex Henrie, Thomas A Miller, Derek Weyhrauch, Michael D Puchalski, Bruce E Bray, Rashmee U Shah, Vikrant G Deshmukh, Rebecca Delaney, H Joseph Yostl, Karen Eilbeck, Martin Tristani-Firouzi, Mark Yandell
Publikováno v: PLOS Digital Health, Vol 1, Iss 1, p e0000004 (2022)
Understanding the conditionally-dependent clinical variables that drive cardiovascular health outcomes is a major challenge for precision medicine. Here, we deploy a recently developed massively scalable comorbidity discovery method called Poisson Bi
Externí odkaz: https://doaj.org/article/d574d208e64a4840aedb92e49088da85
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7
Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease
Autor: Jolanthe Schatterny, Rebecca Delaney, Angela Frank, Michelle Paulsen, Cliff Taggart, Sinéad Weldon, Marcus A. Mall, Simone Schmidt, Declan Doherty, Matthias Hagner, Ryan Brown, Stephanie Hirtz
Publikováno v: American Journal of Respiratory Cell and Molecular Biology
Brown, R, Paulsen, M, Schmidt, S, Schaterrny, J, Frank, A, Hirtz, S, Delaney, R, Doherty, D, Hagner, M, Taggart, C, Weldon, S & Mall, M A 2020, ' Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease ', American Journal of Respiratory Cell and Molecular Biology, vol. 63, no. 3, pp. 300-309 . https://doi.org/10.1165/rcmb.2018-0359OC
Previous studies demonstrated spontaneous type 2 airway inflammation with eosinophilia in juvenile Scnn1b (sodium channel, non-voltage-gated 1, β-subunit)-transgenic (Scnn1b-Tg) mice with muco-obstructive lung disease. IL-1 receptor (IL-1R) signalin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d5e4b99d5f25ac2172c0d7d009af07
https://pubmed.ncbi.nlm.nih.gov/31600081
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8
Sea snake cathelicidin (Hc-cath) exerts a protective effect in mouse models of lung inflammation and infection
Autor: Clifford C. Taggart, John P. Dalton, Jenna Shiels, Brendan Gilmore, Sinéad Weldon, Lauren Kerrigan, Rebecca Delaney, Julianne Megaw, Simon R. Carlile
Publikováno v: Scientific Reports
Carlile, S R, Shiels, J, Kerrigan, L, Delaney, R, Megaw, J, Gilmore, B F, Weldon, S, Dalton, J P & Taggart, C C 2019, ' Sea snake cathelicidin (Hc-cath) exerts a protective effect in mouse models of lung inflammation and infection ', Scientific Reports, vol. 9, no. 1, 6071 . https://doi.org/10.1038/s41598-019-42537-8
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
We investigated the anti-inflammatory and antibacterial activities of Hc-cath, a cathelicidin peptide derived from the venom of the sea snake, Hydrophis cyanocyntus, using in vivo models of inflammation and infection. Hc-cath function was evaluated i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02793e65da39f04c540087295a9c4f8
https://doi.org/10.1038/s41598-019-42537-8
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9
Targeting of cathepsin S reduces cystic fibrosis-like lung disease
Autor: Anthony Abladey, Robert Booth, Leslie Holsinger, Declan Doherty, Ryan Brown, Zhe Zhou-Suckow, Donna M. Small, Christopher J. Scott, Caoifa M. Dougan, Lauren Kerrigan, Sinéad Weldon, Rebecca Delaney, Marcus A. Mall, Guillermo Lopez-Campos, J. Stuart Elborn, Keren S. Borensztajn, Clifford C. Taggart
Publikováno v: Small, D M, Brown, R R, Doherty, D F, Abladey, A, Zhou-Suckow, Z, Delaney, R J, Kerrigan, L, Dougan, C M, Borensztajn, K S, Holsinger, L, Booth, R, Scott, C J, Lopez Campos, G, Elborn, J S, Mall, M A, Weldon, S & Taggart, C C 2019, ' Targeting of Cathepsin S Reduces Cystic Fibrosis-like Lung Disease ', European Respiratory Journal, vol. 53, no. 3, 1801523 . https://doi.org/10.1183/13993003.01523-2018
Cathepsin S (CatS) is upregulated in the lungs of patients with cystic fibrosis (CF). However, its role in CF lung disease pathogenesis remains unclear.In this study, β-epithelial Na+channel-overexpressing transgenic (βENaC-Tg) mice, a model of CF-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13462c499642494e0b572c85f3abf95
https://doi.org/10.1183/13993003.01523-2018
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