Výsledky vyhledávání - "Rebecca Combs"

Akademický článek

Autologous bone marrow-derived MSCs engineered to express oFVIII-FLAG engraft in adult sheep and produce an effective increase in plasma FVIII levels

Autor: Brady Trevisan, Martin Rodriguez, Hailey Medder, Shannon Lankford, Rebecca Combs, John Owen, Anthony Atala, Christopher D. Porada, Graça Almeida-Porada

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

IntroductionHemophilia A (HA) is the most common X-linked bleeding disorder, occurring in 1 in 5,000 live male births and affecting >1 million individuals worldwide. Although advances in protein-based HA therapeutics have improved health outcomes, cu

Externí odkaz: https://doaj.org/article/59c44bce82bc4c60bc3be1f87a9f1c9f

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Administration of FVIII-Expressing Human Placental Cells to Juvenile Sheep Yields Multi-Organ Engraftment, Therapeutic Plasma FVIII Levels and Alter Immune Signaling Pathways to Evade FVIII Inhibitor Induction

Autor: John Owen, Sunil George, M. Graca Almeida-Porada, Christopher B. Doering, Brady Trevisan, Jacqueline Dizon, Rebecca Combs, Anthony Atala, Martin Rodriguez, Jordan E Shields, H. Trent Spencer, Christopher D. Porada, Shannon Lankford

Publikováno v: Blood. 138:3966-3966

We have previously reported that normal juvenile sheep that received weekly intravenous (IV) infusions of human (n=3) or an expression/secretion-optimized, bioengineered human/porcine hybrid (ET3) FVIII protein (n=3) for 5 weeks (20 IU/kg) developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b3d1f4cbb2db050b703d50c025a7d56
https://doi.org/10.1182/blood-2021-151207

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Steroidogenic acute regulatory protein expression is dependent upon post-translational effects of cAMP-dependent protein kinase A

Autor: Barbara J. Clark, Velvizhi Ranganathan, Rebecca Combs

Publikováno v: Molecular and Cellular Endocrinology. 173:183-192

Tropic hormones acutely stimulate adrenal and gonadal steroidogenesis by activation of the cAMP-dependent protein kinase A (PKA) signaling pathway and subsequent induction of Steroidogenic Acute Regulatory (StAR) protein (StAR) expression. We present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0aed8df4a014221e818f0900a65810
https://doi.org/10.1016/s0303-7207(00)00410-x

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Angiotensin II and Cyclic Adenosine 3′,5′-Monophosphate Induce Human Steroidogenic Acute Regulatory Protein Transcription through a Common Steroidogenic Factor-1 Element1

Autor: Rebecca Combs, Barbara J. Clark

Publikováno v: Endocrinology. 140:4390-4398

Steroidogenic acute regulatory protein (StAR) synthesis and steroidogenesis are stimulated by activation of divergent signaling pathways in the adrenal cortex. The two major physiological regulators of aldosterone synthesis in the adrenal zona glomer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52385a498d509c935c2d2ca8ce4f0707
https://doi.org/10.1210/endo.140.10.7085

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The Relationship between Susceptibility to Retinoic Acid Treatment and Protein Kinase Cα Expression in Murine Melanoma Cell Lines

Autor: Rebecca Combs, Richard M. Niles

Publikováno v: Experimental Cell Research. 223:20-28

Retinoic acid (RA)-induced differentiation of B16 mouse melanoma cells is accompanied by a large increase in the amount of PKCalpha protein. Overexpression of PKCalpha in these cells results in a more differentiated phenotype. To determine if these f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e11d594c5a1983999c6ac87a9b39dc2
https://doi.org/10.1006/excr.1996.0054

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Post-translational regulation of steroidogenic acute regulatory protein by cAMP-dependent protein kinase A

Autor: Velvizhi Ranganathan, Barbara J. Clark, Rebecca Combs

Publikováno v: Endocrine research. 26(4)

Adrenal steroid production is stimulated by adrenocorticotropin hormone activation of the cAMP-dependent protein kinase A (PKA) signaling pathway and subsequent induction of Steroidogenic Acute Regulatory (StAR) protein expression. Herein we have com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97ba73709843c87864247d4d659409e
https://pubmed.ncbi.nlm.nih.gov/11196444

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Inhibition of transcription affects synthesis of steroidogenic acute regulatory protein and steroidogenesis in MA-10 mouse Leydig tumor cells

Autor: Karen H. Hales, Dale B. Hales, Barbara J. Clark, Rebecca Combs, Douglas M. Stocco

Publikováno v: Endocrinology. 138(11)

Hormonal induction of steroidogenesis in the adrenal and gonads is dependent on the synthesis and function of the steroidogenic acute regulatory protein (StAR). As a first approach to investigate the role of translation in the control of StAR express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b66c1a794ad65e2533a01759cac6d1c
https://pubmed.ncbi.nlm.nih.gov/9348220

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Web Conferencing As Classroom: A New Opportunity In Distance Learning

Autor: Robert Klonoski, Rebecca Combs

Publikováno v: Contemporary Issues in Education Research (CIER). 2:47

Web conferencing software enables distance learners to attend classes. This paper recounts student reactions to this delivery method and makes suggestions for conducting virtual classes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4564dbf04ddfc255cc82c1107612557
https://doi.org/10.19030/cier.v2i3.1086

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